Q9AFC6 · GTFE_AMYOR

Function

function

D-glucosyltransferase that acts on the aglycone core, transferring D-glucose to the phenolic hydroxyl of OH-Phegly4 to form a devancoaminyl-vancomycin (DVV) intermediate in the biosynthesis of glycopeptide antibiotic vancomycin. Also able to glycosylate A47934, an antibiotic with a teicoplanin-like heptapeptide, but lacking sugar residues.

Miscellaneous

In A.orientalis different glycosyltransferases are involved in biosynthesis of the vancomycin group of antibiotics. GtfA (AC P96558), GtfB (AC P96559) and GtfC (AC P96560) are involved in biosynthesis of antibiotic chloroeremomycin, while GtfD (AC Q9AFC7) and GtfE are involved in biosynthesis of vancomycin.

Pathway

Antibiotic biosynthesis; vancomycin biosynthesis.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functionhexosyltransferase activity
Molecular FunctionUDP-glycosyltransferase activity
Biological Processcarbohydrate metabolic process
Biological Processlipid glycosylation
Biological Processvancomycin biosynthetic process

Keywords

Enzyme and pathway databases

Protein family/group databases

    • GT1Glycosyltransferase Family 1

Names & Taxonomy

Protein names

Gene names

    • Name
      gtfE

Organism names

  • Taxonomic identifier
  • Strain
    • ATCC 19795 / DSM 40040 / CBS 547.68 / JCM 4235 / KCTC 9412 / NBRC 12806 / NCIMB 12945 / M43-05865
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Pseudonocardiales > Pseudonocardiaceae > Amycolatopsis

Accessions

  • Primary accession
    Q9AFC6

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004304401-409Glycosyltransferase GtfE

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the glycosyltransferase 28 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    409
  • Mass (Da)
    43,139
  • Last updated
    2001-06-01 v1
  • Checksum
    6D3A8C83E1679F0B
MRVLLSTCGSRGDVEPLVALAVRLRARGAEVRMCAPPDCADRLAEVGVPHLPLGRSARPAAAGEAKPLTAEDMLRFTTETIAMQFDRIPAAAEGCDAVVTTGLLAAALGVRSVAEKLGIPYFYAFHCPSYVPSPYYAPPPPLGEPPAPEGTDIRALWERNNQSAFRRYGAPLKSQRAAIGLPPVEDIFEHGYTDHPWMAADQVLAPLQPTDLDAVQTGAWILPDERPLSPEMEAFLDAGTPPVYLGFGSLRAPADAAKVAIEAIRAHGRRVILSRGWADLVLPDDRDDCFATGEVNQQVLFRRVAAVIHHGGAGTTHVATRAGAPQILVPQIADQPYYAGRVAELGIGVAHDGPTPTFESLSAALTTALAPETRVRAEAVAGTVLTDGAAAAADLLFAAVGEEKPAVPA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF351622
EMBL· GenBank· DDBJ
AAK31353.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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