Q99QV3 · DRP35_STAAM
- ProteinLactonase drp35
- Genedrp35
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids324 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Exhibits lactonase activity. Acts in cells with perturbed membrane integrity and is possibly related to the membrane homeostasis (By similarity).
Cofactor
Note: Binds 2 Ca2+ ions per subunit.
pH Dependence
Optimum pH is about 6.0.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 47 | Ca2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: E | ||||||
Binding site | 109 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 111 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 129 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 132 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 134 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 137 | Ca2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 184 | Ca2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: N | ||||||
Active site | 235 | Proton donor | ||||
Sequence: D | ||||||
Binding site | 235 | Ca2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 236 | Ca2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: S |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | hydrolase activity | |
Molecular Function | metal ion binding |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLactonase drp35
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus
Accessions
- Primary accessionQ99QV3
Proteomes
Subcellular Location
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 47 | Loss of activity. | ||||
Sequence: E → A | ||||||
Mutagenesis | 47 | Loss of activity due to inability to bind calcium ion. | ||||
Sequence: E → Q | ||||||
Mutagenesis | 47 | Loss of activity. | ||||
Sequence: E → S | ||||||
Mutagenesis | 63 | 2.5-fold increase in lactonase activity. | ||||
Sequence: F → A | ||||||
Mutagenesis | 92 | Increase in lactonase activity. | ||||
Sequence: K → A | ||||||
Mutagenesis | 137 | Loss of activity. | ||||
Sequence: D → A | ||||||
Mutagenesis | 137 | Loss of activity but still able to bind calcium ion. | ||||
Sequence: D → N | ||||||
Mutagenesis | 137 | Loss of activity. | ||||
Sequence: D → S | ||||||
Mutagenesis | 138 | Decrease in lactonase activity. | ||||
Sequence: D → A | ||||||
Mutagenesis | 151 | Decrease in lactonase activity. | ||||
Sequence: D → A | ||||||
Mutagenesis | 184 | Loss of activity. | ||||
Sequence: N → A | ||||||
Mutagenesis | 184 | Decrease in lactonase activity. | ||||
Sequence: N → D | ||||||
Mutagenesis | 184 | Loss of activity. | ||||
Sequence: N → S | ||||||
Mutagenesis | 185 | Decrease in lactonase activity. | ||||
Sequence: G → A | ||||||
Mutagenesis | 235 | Loss of activity. | ||||
Sequence: D → A | ||||||
Mutagenesis | 235 | Loss of activity due to inability to bind calcium ion. | ||||
Sequence: D → N | ||||||
Mutagenesis | 235 | Loss of activity. | ||||
Sequence: D → S | ||||||
Mutagenesis | 236 | Decrease in lactonase activity. | ||||
Sequence: S → A | ||||||
Mutagenesis | 237 | Increase in lactonase activity. | ||||
Sequence: C → A | ||||||
Mutagenesis | 280 | Increase in lactonase activity. | ||||
Sequence: R → A | ||||||
Mutagenesis | 301 | Increase in lactonase activity. | ||||
Sequence: E → A |
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000259749 | 1-324 | Lactonase drp35 | |||
Sequence: MMSQQDLPTLFYSGKSNSAVPIISESELQTITAEPWLEISKKGLQLEGLNFDRQGQLFLLDVFEGNIFKINPETKEIKRPFVSHKANPAAIKIHKDGRLFVCYLGDFKSTGGIFAATENGDNLQDIIEDLSTAYCIDDMVFDSKGGFYFTDFRGYSTNPLGGVYYVSPDFRTVTPIIQNISVANGIALSTDEKVLWVTETTANRLHRIALEDDGVTIQPFGATIPYYFTGHEGPDSCCIDSDDNLYVAMYGQGRVLVFNKRGYPIGQILIPGRDEGHMLRSTHPQFIPGTNQLIICSNDIEMGGGSMLYTVNGFAKGHQSFQFQ |
Structure
Sequence
- Sequence statusComplete
- Length324
- Mass (Da)35,964
- Last updated2001-06-01 v1
- ChecksumA2C94FCB38F2F4AC
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BA000017 EMBL· GenBank· DDBJ | BAB58850.1 EMBL· GenBank· DDBJ | Genomic DNA |