Q99PN0 · SC5A5_MOUSE

  • Protein
    Sodium/iodide cotransporter
  • Gene
    Slc5a5
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Sodium:iodide symporter that mediates the transport of iodide into the thyroid gland (PubMed:11716040, PubMed:18372236, PubMed:32084174).
Can also mediate the transport of chlorate, thiocynate, nitrate and selenocynate (By similarity).

Catalytic activity

Activity regulation

Perchlorate inhibits iodide transport activity.

Kinetics

KM SUBSTRATE pH TEMPERATURE[C] NOTES EVIDENCE
26 μMiodide

Features

Showing features for site.

TypeIDPosition(s)Description
Site242Required for homodimerization
Site243Required for homodimerization
Site471Required for homodimerization

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentplasma membrane
Molecular Functioniodide transmembrane transporter activity
Molecular Functionsodium:iodide symporter activity
Molecular Functionsymporter activity
Biological Processiodide transmembrane transport
Biological Processiodide transport
Biological Processsodium ion transport
Biological Processthyroid hormone generation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sodium/iodide cotransporter
  • Short names
    Na(+)/I(-) cotransporter
  • Alternative names
    • Sodium-iodide symporter (Na(+)/I(-) symporter)
    • Solute carrier family 5 member 5

Gene names

    • Name
      Slc5a5
    • Synonyms
      Nis

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6 X DBA/2
    • BALB/cJ
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q99PN0
  • Secondary accessions
    • B2RPX6

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Cytoplasm

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-16Extracellular
Transmembrane17-37Helical
Topological domain38-53Cytoplasmic
Transmembrane54-74Helical
Topological domain75-88Extracellular
Transmembrane89-109Helical
Topological domain110-136Cytoplasmic
Transmembrane137-157Helical
Topological domain158-163Extracellular
Transmembrane164-184Helical
Topological domain185-186Cytoplasmic
Transmembrane187-207Helical
Topological domain208-241Extracellular
Transmembrane242-262Helical
Topological domain263-286Cytoplasmic
Transmembrane287-307Helical
Topological domain308-326Extracellular
Transmembrane327-347Helical
Topological domain348-391Cytoplasmic
Transmembrane392-412Helical
Topological domain413-416Extracellular
Transmembrane417-437Helical
Topological domain438-444Cytoplasmic
Transmembrane445-465Helical
Topological domain466-520Extracellular
Transmembrane521-541Helical
Topological domain542-618Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001053841-618Sodium/iodide cotransporter
Glycosylation485N-linked (GlcNAc...) asparagine
Glycosylation497N-linked (GlcNAc...) asparagine
Modified residue551Phosphoserine; by PKA

Post-translational modification

Glycosylated.

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Homodimer; disulfide-linked (By similarity).
Monomer (PubMed:18372236).
Homooligomer (PubMed:18372236).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region571-618Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    618
  • Mass (Da)
    65,568
  • Last updated
    2001-06-01 v1
  • Checksum
    448AC5FE9AB5118E
MEGAEAGARATFGPWDYGVFATMLLVSTGIGLWVGLARGGQRSADDFFTGGRQLAAVPVGLSLAASFMSAVQVLGVPAEAARYGLKFLWMCVGQLLNSLLTALLFLPIFYRLGLTSTYQYLELRFSRAVRLCGTLQYLVATMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTLYTTVGGMKAVVWTDVFQVVVMLVGFWVILARGVMLMGGPWNVLSLAQNHSRINLMDFDPDPRSRYTFWTFVVGGSLVWLSMYGVNQAQVQRYVACHTERKAKLALLVNQLGLFLIVASAACCGIVMFVYYKDCDPLLTGRIAAPDQYMPLLVLDIFEDLPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRMPSLAPRKLVFISKGLSFIYGSTCLTVAALSSLLGGGVLQGSFTVMGVISGPLLGAFTLGMLLPACNTPGVLSGLTAGLAVSLWVAVGATLYPPGEQTMGVLPTSAAGCTNASVLPSPPGAANTSRGIPSSGMDSGRPAFADTFYAVSYLYYGALGTLTTMLCGALISYLTGPTKRSSLGPGLLWWDLARQTASVAPKEDTTTLEDSLVKGPEDIPAATKKPPGFRPEAETHPLYLGHDVETNL

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
G3X8P5G3X8P5_MOUSESlc5a5618

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF235001
EMBL· GenBank· DDBJ
AAK00232.1
EMBL· GenBank· DDBJ
mRNA
AF380353
EMBL· GenBank· DDBJ
AAK59274.1
EMBL· GenBank· DDBJ
mRNA
BC137650
EMBL· GenBank· DDBJ
AAI37651.1
EMBL· GenBank· DDBJ
mRNA
BC137651
EMBL· GenBank· DDBJ
AAI37652.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp