Myocardial Hypertrophy and Fibrosis Are Associated with Cardiomyocyte Beta-Catenin and TRPC6/Calcineurin/NFAT Signaling in Spontaneously Hypertensive Rats with 5/6 Nephrectomy.
Findings indicate that TRPC6-ERK1/2 activation may increase DGC invulnerability to SE by regulating LONP1 expression as well as mitochondrial dynamics.
Our data provide evidence that the acid sphingomyelinase/ceramide system regulates TRPC6 channels likely by controlling their recruitment to specific lipid subdomains
the present results suggested that the AngII/TRPC6/NFAT axis may be a crucial signaling pathway in podocytes that is necessary for maintaining the integrity of the glomerular filtration barrier
FK506 improved urodynamic indices of overactive bladder (OAB) rats and TRPC6 was expressed in rats and human bladder tissues. TRPC6 elevation in OAB rats was inhibited by FK506 and this inhibition coincided with improvements in urodynamic indices.
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