Q99N48 · SYTL3_MOUSE
- ProteinSynaptotagmin-like protein 3
- GeneSytl3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids607 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | exocytic vesicle | |
Cellular Component | membrane | |
Cellular Component | plasma membrane | |
Molecular Function | calcium-dependent phospholipid binding | |
Molecular Function | neurexin family protein binding | |
Molecular Function | phospholipid binding | |
Molecular Function | small GTPase binding | |
Molecular Function | zinc ion binding | |
Biological Process | exocytosis | |
Biological Process | intracellular protein transport |
Names & Taxonomy
Protein names
- Recommended nameSynaptotagmin-like protein 3
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ99N48
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endomembrane system ; Peripheral membrane protein
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 336-337 | Binds phospholipids only in the absence of divalent cations. | ||||
Sequence: EE → QQ | ||||||
Mutagenesis | 359-361 | Binds phospholipids only in the absence of divalent cations. | ||||
Sequence: KRK → QQQ |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 39 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000190215 | 1-607 | Synaptotagmin-like protein 3 | |||
Sequence: MAHEVDLESFKELERDIILRVLYRDQTVQSTEEERVRKLKSHLQHLRWKGAKSSSQEYKEKCCARCQRALGLLLNRGAVCQGCSHRVCSECRVFLRRTRAWKCTVCFEDRNVKIKTGEWFFEERARKFPTAGRRETAGAKLLQSYQRLSKISVVPPTPPPFSESQCSSSSRLQELGHFRGFNKSVENLFLSVTTQMRKLSKSQNDMTSEKHLLAMDPRQCVGHTERRSQSDTAVNVTSRKASTPDILKAFHQEDPKHPPDPVLKQDTPPSSPTHSAVFSGGLRHGSLISINSTCTEMGNFDNANVTGEIEFAIHYCVKSCSLEICIKTCKNLAYGEEKKRKCNPYVKTYLLPDRSSQGKRKTRVQKNTLDPTFEETLKYQVDPGQLMTRRLQVSVWHLGTLARRVFLGEVILPLAMWDFKDSTAQNARWYPLRAKAEKYEENIPQNNGELAVRAKLVLPAGPRKPQEAQEGQLALNGQLCLVVLGAKNLPVRSDGTLNSFVKGCLTLPNQQKLRVKSPVLKKQACPQWKHSFVFNGVSSSQLRQSTLELTVWDQAIFGMNDRLLGEARLGSKGGAAGCPDSGSQSKLQWHRVLSSPNLWTDMTLVLH |
Proteomic databases
PTM databases
Expression
Tissue specificity
Highly expressed in spleen and lung. Detected at lower levels in heart and testis.
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 4-123 | RabBD | ||||
Sequence: EVDLESFKELERDIILRVLYRDQTVQSTEEERVRKLKSHLQHLRWKGAKSSSQEYKEKCCARCQRALGLLLNRGAVCQGCSHRVCSECRVFLRRTRAWKCTVCFEDRNVKIKTGEWFFEE | ||||||
Region | 221-279 | Disordered | ||||
Sequence: VGHTERRSQSDTAVNVTSRKASTPDILKAFHQEDPKHPPDPVLKQDTPPSSPTHSAVFS | ||||||
Compositional bias | 226-242 | Polar residues | ||||
Sequence: RRSQSDTAVNVTSRKAS | ||||||
Compositional bias | 246-261 | Basic and acidic residues | ||||
Sequence: ILKAFHQEDPKHPPDP | ||||||
Domain | 305-430 | C2 1 | ||||
Sequence: VTGEIEFAIHYCVKSCSLEICIKTCKNLAYGEEKKRKCNPYVKTYLLPDRSSQGKRKTRVQKNTLDPTFEETLKYQVDPGQLMTRRLQVSVWHLGTLARRVFLGEVILPLAMWDFKDSTAQNARWY | ||||||
Domain | 458-590 | C2 2 | ||||
Sequence: LPAGPRKPQEAQEGQLALNGQLCLVVLGAKNLPVRSDGTLNSFVKGCLTLPNQQKLRVKSPVLKKQACPQWKHSFVFNGVSSSQLRQSTLELTVWDQAIFGMNDRLLGEARLGSKGGAAGCPDSGSQSKLQWH |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 5 isoforms produced by Alternative splicing.
Q99N48-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsSlp3-a
- Length607
- Mass (Da)68,568
- Last updated2003-07-25 v2
- ChecksumF9F404D2D77A6351
Q99N48-2
- Name2
- SynonymsSlp3-a + 3S-I
- Differences from canonical
- 1-195: Missing
Q99N48-3
- Name3
- SynonymsSlp3-b, Slp3-a delta 3S-II
- Differences from canonical
- 1-214: Missing
Q99N48-4
- Name4
- SynonymsSlp3-b + 3S-III
- Differences from canonical
- 1-296: Missing
Q99N48-5
- Name5
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Features
Showing features for alternative sequence, compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_007895 | 1-195 | in isoform 2 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_007896 | 1-214 | in isoform 3 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_007897 | 1-296 | in isoform 4 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_007898 | 111-114 | in isoform 5 | |||
Sequence: NVKI → ANGR | ||||||
Alternative sequence | VSP_007899 | 115-607 | in isoform 5 | |||
Sequence: Missing | ||||||
Compositional bias | 226-242 | Polar residues | ||||
Sequence: RRSQSDTAVNVTSRKAS | ||||||
Sequence conflict | 229 | in Ref. 1; BAB32653 | ||||
Sequence: Q → R | ||||||
Compositional bias | 246-261 | Basic and acidic residues | ||||
Sequence: ILKAFHQEDPKHPPDP |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB050743 EMBL· GenBank· DDBJ | BAB32653.1 EMBL· GenBank· DDBJ | mRNA | ||
AB057758 EMBL· GenBank· DDBJ | BAB41086.1 EMBL· GenBank· DDBJ | mRNA | ||
AB057764 EMBL· GenBank· DDBJ | BAB41092.1 EMBL· GenBank· DDBJ | mRNA | ||
AB057765 EMBL· GenBank· DDBJ | BAB41093.1 EMBL· GenBank· DDBJ | mRNA | ||
AB057766 EMBL· GenBank· DDBJ | BAB41094.1 EMBL· GenBank· DDBJ | mRNA | ||
BC022608 EMBL· GenBank· DDBJ | AAH22608.1 EMBL· GenBank· DDBJ | mRNA | ||
BC106102 EMBL· GenBank· DDBJ | AAI06103.1 EMBL· GenBank· DDBJ | mRNA | ||
AK079850 EMBL· GenBank· DDBJ | BAC37766.1 EMBL· GenBank· DDBJ | mRNA |