Q99MY5 · Q99MY5_MOUSE
- ProteinSplicing factor Sc35
- GeneSrsf2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids
- Protein existenceEvidence at transcript level
- Annotation score1/5
Publications for Q99MY5
Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing.
- CategorySequences
- SourceMGI: 98284
Cited inMapped toThe biogenesis of the coiled body during early mouse development.
- CategoriesFunction, Subcellular Location
- SourceMGI: 98284
SRSF2 is essential for maintaining pancreatic beta-cell identity and regulating glucose homeostasis in mice.
- AnnotationSRSF2 is essential for maintaining pancreatic beta-cell identity and regulating glucose homeostasis in mice.
- SourceGeneRif: 20382
PARP inhibition leads to synthetic lethality with key splicing-factor mutations in myelodysplastic syndromes.
- AnnotationPARP inhibition leads to synthetic lethality with key splicing-factor mutations in myelodysplastic syndromes.
- SourceGeneRif: 20382
A mitochondrial surveillance mechanism activated by SRSF2 mutations in hematologic malignancies.
- AnnotationA mitochondrial surveillance mechanism activated by SRSF2 mutations in hematologic malignancies.
- CategoryFunction
- SourceGeneRif: 20382
SRSF2 mutation cooperates with ASXL1 truncated alteration to accelerate leukemogenesis.
- CategoryFunction
- SourceMGI: 98284
SRSF2 mutation reduces polycythemia and impairs hematopoietic progenitor functions in JAK2V617F-driven myeloproliferative neoplasm.
- AnnotationSRSF2 mutation reduces polycythemia and impairs hematopoietic progenitor functions in JAK2V617F-driven myeloproliferative neoplasm.
- CategoryFunction
- SourceGeneRif: 20382
SRSF2 is required for mRNA splicing during spermatogenesis.
- CategoryFunction
- SourceMGI: 98284
SRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development in mice.
- AnnotationSRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development in mice.
- CategoriesFunction, Phenotypes & Variants
Inflammatory signals from fatty bone marrow support DNMT3A driven clonal hematopoiesis.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 98284
SRSF2 in Sertoli cells is essential for testicular development and spermatogenesis in mice.
- AnnotationSRSF2 in Sertoli cells is essential for testicular development and spermatogenesis in mice.
- CategorySubcellular Location
Srsf2<sup>P95H/+</sup> co-operates with loss of TET2 to promote myeloid bias and initiate a chronic myelomonocytic leukemia-like disease in mice.
- AnnotationSrsf2[P95H/+]
- CategoriesFunction, Phenotypes & Variants
RUNX1 deficiency cooperates with SRSF2 mutation to induce multilineage hematopoietic defects characteristic of MDS.
- AnnotationRUNX1 deficiency cooperates with SRSF2 mutation to induce multilineage hematopoietic defects characteristic of MDS.
- CategoriesFunction, Phenotypes & Variants
- SourceGeneRif: 20382
Single-cell architecture and functional requirement of alternative splicing during hematopoietic stem cell formation.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 98284
BCAS2 is involved in alternative splicing and mouse oocyte development.
- CategoryFunction
- SourceMGI: 98284
EXOSC10/Rrp6 is essential for the eight-cell embryo/morula transition.
- CategoryFunction
- SourceMGI: 98284
Genome-wide screening identifies cell-cycle control as a synthetic lethal pathway with SRSF2P95H mutation.
- AnnotationGenome-wide screening identifies cell-cycle control as a synthetic lethal pathway with SRSF2P95H mutation.
- CategoriesFunction, Phenotypes & Variants
- SourceGeneRif: 20382
Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 98284
Loss of SRSF2 triggers hepatic progenitor cell activation and tumor development in mice.
- AnnotationLoss of SRSF2 triggers hepatic progenitor cell activation and tumor development in mice.
- CategoriesFunction, Phenotypes & Variants
Srsf10 and the minor spliceosome control tissue-specific and dynamic SR protein expression.
- CategoryFunction
- SourceMGI: 98284