Q99MQ1 · BICC1_MOUSE

  • Protein
    Protein bicaudal C homolog 1
  • Gene
    Bicc1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Putative RNA-binding protein. May be involved in regulating gene expression during embryonic development.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Molecular FunctionRNA binding
Biological Processdetermination of left/right symmetry
Biological Processheart development
Biological Processkidney development
Biological Processnegative regulation of canonical Wnt signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein bicaudal C homolog 1
  • Short names
    Bic-C

Gene names

    • Name
      Bicc1

Organism names

  • Taxonomic identifier
  • Strains
    • FVB/N-3
    • NOD
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q99MQ1
  • Secondary accessions
    • Q6P6K3
    • Q8C286

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002677151-977Protein bicaudal C homolog 1
Modified residue27Phosphoserine
Modified residue32Phosphoserine
Modified residue45Phosphoserine
Modified residue400N6-acetyllysine
Modified residue614Phosphoserine
Modified residue681Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

In the adult, predominantly expressed in heart and kidney. In 8 week old mice, expressed in growing primary oocytes and in the stromal cells of the theca.

Developmental stage

In the developing embryo, first detected at the rostral tip of the primitive streak, Hensen's node, at the late streak stage. At the late headfold stage, expression demarcates the layer of the node from which definitive endoderm and midline mesoderm arises. At 6-8 somite stage observed in the definitive endoderm. Strong expression is detected in the caudal intestinal portal. At 12-15 somite stage is still present in the hindgut, but transient expression is also seen in tissues of neural and mesodermal origins. At 13 dpc present around all sites of cartilage formation, such as cervical vertebral bodies, ribs and Merckel's cartilage. Additionally, expressed in the derivatives of the pleuroperitoneal membrane, the diaphragm and the pericardium, as well as the mesenchyme of the developing lung. Expressed in both the mesonephros and metanephros.

Gene expression databases

Interaction

Subunit

Interacts (via KH domains) with ANKS6 (via SAM domain) in an RNA-dependent manner. Interacts with ANKS3 (PubMed:25671767).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-27Polar residues
Region1-43Disordered
Domain134-201KH 1
Domain286-350KH 2
Compositional bias590-621Polar residues
Region590-622Disordered
Region667-702Disordered
Compositional bias794-811Polar residues
Region794-848Disordered
Domain875-938SAM

Sequence similarities

Belongs to the BicC family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q99MQ1-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    977
  • Mass (Da)
    105,037
  • Last updated
    2001-06-01 v1
  • Checksum
    3A5A7B7F2CA84918
MASQSEPGYLAAAQSDPGSNSERSTDSPVAGSEDDLVAAAPLLHSPEWSEERFRVDRKKLEAMLQAAAEGKGRSGEDFFQKIMEETNTQIAWPSKLKIGAKSKKDPHIKVSGKKEDVKEAKEMIMSVLDTKSNRVTLKMDVSHTEHSHVIGKGGNNIKKVMEDTGCHIHFPDSNRNNQAEKSNQVSIAGQPAGVESARARIRELLPLVLMFELPIAGILQPVPDPNTPSIQHISQTYSVSVSFKQRSRMYGATVTVRGSQNNTNAVKEGTAMLLEHLAGSLASAIPVSTQLDIAAQHHLFMMGRNGSNVKHIMQRTGAQIHFPDPSNPQKKSTVYLQGTIESVCLARQYLMGCLPLVLMFDMKEDIEVDPQVIAQLMEQLDVFISIKPKPKQPSKSVIVKSVERNALNMYEARKCLLGLESSGVSIATSLSPASCPAGLACPSLDILASAGLGLTGLGLLGPTTLSLNTSATPNSLLNALNTSVSPLQSSSSGTPSPTLWAPPIANTASATGFSTIPHLMLPSTAQATLTNILLSGVPTYGHTAPSPPPGLTPVDVHINSMQTEGKNISASINGHVQPANMKYGPLSTSSLGEKVLSSNHGDPSMQTAGPEQASPKSNSVEGCNDAFVEVGMPRSPSHSGNAGDLKQMLGASKVSCAKRQTVELLQGTKNSHLHGTDRLLSDPELSATESPLADKKAPGSERAAERAAAAQQKSERARLASQPTYVHMQAFDYEQKKLLATKAMLKKPVVTEVRTPTNTWSGLGFSKSMPAETIKELRRANHVSYKPTMTTAYEGSSLSLSRSSSREHLASGSESDNWRDRNGIGPMGHSEFSAPIGSPKRKQNKSREHYLSSSNYMDCISSLTGSNGCNLNSCFKGSDLPELFSKLGLGKYTDVFQQQEIDLQTFLTLTDQDLKELGITTFGARRKMLLAISELSKNRRKLFEPPNASCTSFLEGGASGRLPRQYHSDIASVSGRW

Q99MQ1-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-82: Missing
    • 934-977: ELSKNRRKLFEPPNASCTSFLEGGASGRLPRQYHSDIASVSGRW → VCDSVQIRNKILRAARIL

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
G3X8S6G3X8S6_MOUSEBicc1951

Features

Showing features for compositional bias, alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Compositional bias1-27Polar residues
Alternative sequenceVSP_0219501-82in isoform 2
Sequence conflict276in Ref. 2; BAC40732
Compositional bias590-621Polar residues
Compositional bias794-811Polar residues
Alternative sequenceVSP_021951934-977in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF319464
EMBL· GenBank· DDBJ
AAK27347.1
EMBL· GenBank· DDBJ
mRNA
AK089066
EMBL· GenBank· DDBJ
BAC40732.1
EMBL· GenBank· DDBJ
mRNA
BC062174
EMBL· GenBank· DDBJ
AAH62174.1
EMBL· GenBank· DDBJ
mRNA
BC111523
EMBL· GenBank· DDBJ
AAI11524.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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