Q99M80 · PTPRT_MOUSE
- ProteinReceptor-type tyrosine-protein phosphatase T
- GenePtprt
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1454 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May be involved in both signal transduction and cellular adhesion in the CNS. May have specific signaling roles in the tyrosine phosphorylation/dephosphorylation pathway in the anterior compartment of the adult cerebellar cortex.
Catalytic activity
- H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 1065 | substrate | ||||
Sequence: D | ||||||
Active site | 1097 | Phosphocysteine intermediate | ||||
Sequence: C | ||||||
Binding site | 1097-1103 | substrate | ||||
Sequence: CSAGAGR | ||||||
Binding site | 1141 | substrate | ||||
Sequence: Q | ||||||
Active site | 1391 | Phosphocysteine intermediate | ||||
Sequence: C |
GO annotations
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameReceptor-type tyrosine-protein phosphatase T
- EC number
- Short namesR-PTP-T
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ99M80
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 30-770 | Extracellular | ||||
Sequence: QSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTWEKPMLDPAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGALNVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTSQRSISKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDADTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASNLDSLHYFAAELKPSNLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLATKGAPMGSAQVTPGTPLCLLTTASTQNSNTVEPEKQVDNTVKM | ||||||
Transmembrane | 771-791 | Helical | ||||
Sequence: AGVIAGLLMFIIILLGVMLTI | ||||||
Topological domain | 792-1454 | Cytoplasmic | ||||
Sequence: KRRKLAKKQKETQSGAQREMGPVASTDKPTAKLGTNRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQLCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, glycosylation, disulfide bond, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-29 | |||||
Sequence: MGSLGGLALCLLRLLLLGLQRPPLPGAGA | ||||||
Chain | PRO_0000025464 | 30-1454 | Receptor-type tyrosine-protein phosphatase T | |||
Sequence: QSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTWEKPMLDPAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGALNVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTSQRSISKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDADTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASNLDSLHYFAAELKPSNLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLATKGAPMGSAQVTPGTPLCLLTTASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRKLAKKQKETQSGAQREMGPVASTDKPTAKLGTNRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQLCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF | ||||||
Glycosylation | 82 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 102 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 141 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 212 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 217↔271 | |||||
Sequence: CIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTSQRSISKYRC | ||||||
Glycosylation | 425 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 514 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 551 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 605 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 658 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 688 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Modified residue | 1221 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expression is restricted to the CNS. Distributed throughout the brain and spinal cord.
Developmental stage
Exceptionally high levels found in the cortex and olfactory bulbs during perinatal development and are down-regulated during postnatal week 2. Expression in the cerebellar cortex is restricted to the granule cell layer of lobules 1-6. Anterior and posterior compartments become discernible only during postnatal weeks 2 and 6.
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 34-195 | MAM | ||||
Sequence: GGCSFDEHYSNCGYSVALGTNGFTWEQINTWEKPMLDPAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGALNVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVDEVRVLAHPCRK | ||||||
Domain | 197-288 | Ig-like C2-type | ||||
Sequence: PHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTSQRSISKYRCVIRSDGGSGVSNYAELI | ||||||
Domain | 295-388 | Fibronectin type-III 1 | ||||
Sequence: PIAPPELLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTKCA | ||||||
Domain | 393-487 | Fibronectin type-III 2 | ||||
Sequence: GPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEED | ||||||
Domain | 488-594 | Fibronectin type-III 3 | ||||
Sequence: VPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPS | ||||||
Domain | 670-767 | Fibronectin type-III 4 | ||||
Sequence: AELKPSNLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLATKGAPMGSAQVTPGTPLCLLTTASTQNSNTVEPEKQVDNT | ||||||
Region | 800-852 | Disordered | ||||
Sequence: QKETQSGAQREMGPVASTDKPTAKLGTNRNDEGFSSSSQDVNGFTDGSRGELS | ||||||
Compositional bias | 820-852 | Polar residues | ||||
Sequence: PTAKLGTNRNDEGFSSSSQDVNGFTDGSRGELS | ||||||
Domain | 902-1156 | Tyrosine-protein phosphatase 1 | ||||
Sequence: FKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEA | ||||||
Domain | 1188-1450 | Tyrosine-protein phosphatase 2 | ||||
Sequence: IKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQLCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEY |
Sequence similarities
Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 5 isoforms produced by Alternative splicing.
Q99M80-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length1,454
- Mass (Da)163,012
- Last updated2003-07-19 v2
- ChecksumC60464F7B423F8A8
Q99M80-2
- Name2
- Differences from canonical
- 731-749: Missing
- 1007-1007: R → RHPAEHTVGTATLGRAASPGM
Q99M80-3
- Name3
- SynonymsRPTPrho2
Q99M80-4
- Name4
- SynonymsRPTPrho1
- Differences from canonical
- 731-749: Missing
Q99M80-5
- Name5
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
B1AQN2 | B1AQN2_MOUSE | Ptprt | 1454 |
Features
Showing features for sequence conflict, alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 13-16 | in Ref. 1; AAD34158 | ||||
Sequence: Missing | ||||||
Sequence conflict | 21 | in Ref. 1; AAD34158 | ||||
Sequence: R → P | ||||||
Sequence conflict | 34-37 | in Ref. 1; AAD34158 | ||||
Sequence: GGCS → RGVF | ||||||
Sequence conflict | 87 | in Ref. 4; AAF82401 | ||||
Sequence: A → T | ||||||
Sequence conflict | 254 | in Ref. 4; AAF82401 | ||||
Sequence: A → S | ||||||
Sequence conflict | 266 | in Ref. 4; AAF82401 | ||||
Sequence: I → V | ||||||
Sequence conflict | 602 | in Ref. 4; AAF82401 | ||||
Sequence: T → S | ||||||
Alternative sequence | VSP_007803 | 731-749 | in isoform 2, isoform 3, isoform 4 and isoform 5 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_007804 | 794 | in isoform 3 | |||
Sequence: R → RRNAYSYSYYL | ||||||
Alternative sequence | VSP_007805 | 794 | in isoform 5 | |||
Sequence: R → RRNAYSYSYYLSQR | ||||||
Compositional bias | 820-852 | Polar residues | ||||
Sequence: PTAKLGTNRNDEGFSSSSQDVNGFTDGSRGELS | ||||||
Sequence conflict | 822 | in Ref. 4; AAF82401 | ||||
Sequence: A → T | ||||||
Sequence conflict | 825 | in Ref. 4; AAF82401 | ||||
Sequence: G → S | ||||||
Sequence conflict | 844-845 | in Ref. 4; AAF82401 | ||||
Sequence: TD → N | ||||||
Alternative sequence | VSP_007806 | 1007 | in isoform 2 | |||
Sequence: R → RHPAEHTVGTATLGRAASPGM | ||||||
Sequence conflict | 1016 | in Ref. 4; AAF82401 | ||||
Sequence: D → A | ||||||
Sequence conflict | 1049 | in Ref. 1; AAD34158 | ||||
Sequence: Y → H | ||||||
Sequence conflict | 1050 | in Ref. 4; AAF82401 | ||||
Sequence: H → N | ||||||
Sequence conflict | 1076 | in Ref. 4; AAF82401 | ||||
Sequence: L → V | ||||||
Sequence conflict | 1103 | in Ref. 1; AAD34158 | ||||
Sequence: R → K | ||||||
Sequence conflict | 1259 | in Ref. 4; AAF82401 | ||||
Sequence: F → L | ||||||
Sequence conflict | 1266 | in Ref. 4; AAF82401 | ||||
Sequence: L → I | ||||||
Sequence conflict | 1269 | in Ref. 4; AAF82401 | ||||
Sequence: T → S |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF152556 EMBL· GenBank· DDBJ | AAD34158.4 EMBL· GenBank· DDBJ | mRNA | ||
AY026861 EMBL· GenBank· DDBJ | AAK18741.1 EMBL· GenBank· DDBJ | mRNA | ||
AY026862 EMBL· GenBank· DDBJ | AAK18742.1 EMBL· GenBank· DDBJ | mRNA | ||
AY026863 EMBL· GenBank· DDBJ | AAK18743.1 EMBL· GenBank· DDBJ | mRNA | ||
AF244125 EMBL· GenBank· DDBJ | AAF44712.1 EMBL· GenBank· DDBJ | mRNA | ||
AF162856 EMBL· GenBank· DDBJ | AAF82400.2 EMBL· GenBank· DDBJ | mRNA | ||
AF162857 EMBL· GenBank· DDBJ | AAF82401.1 EMBL· GenBank· DDBJ | mRNA |