Q99KS2 · NGRN_MOUSE
- ProteinNeugrin
- GeneNgrn
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids293 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Cellular Component | intercellular bridge | |
Cellular Component | mitochondrial membrane | |
Cellular Component | mitotic spindle | |
Cellular Component | nuclear body | |
Cellular Component | nucleus | |
Molecular Function | rRNA binding | |
Biological Process | cell differentiation | |
Biological Process | mitochondrial ribosome assembly | |
Biological Process | positive regulation of mitochondrial translation |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameNeugrin
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ99KS2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, modified residue, glycosylation.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-18 | ||||
Chain | PRO_0000294484 | 19-293 | Neugrin | ||
Modified residue | 41 | Phosphoserine | |||
Glycosylation | 185 | N-linked (GlcNAc...) asparagine | |||
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in heart, brain, liver and kidney. In brain, mainly expressed in neurons rather than glial cells.
Induction
Highly up-regulated in neuroblastostoma cells by RA and MG132 treatment inducing neurite outgrowth.
Developmental stage
Level of expression increases with embryonal development.
Gene expression databases
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 177-194 | Polar residues | |||
Region | 177-210 | Disordered | |||
Region | 224-254 | Disordered | |||
Compositional bias | 229-248 | Polar residues | |||
Sequence similarities
Belongs to the neugrin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 2 isoforms produced by Alternative splicing.
Q99KS2-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length293
- Mass (Da)32,447
- Last updated2010-10-05 v3
- MD5 ChecksumF4CC861B981630EB4AA586F061145041
Q99KS2-2
- Name2
- NoteMay be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Sequence caution
Features
Showing features for alternative sequence, sequence conflict, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Alternative sequence | VSP_039712 | 55-66 | in isoform 2 | ||
Alternative sequence | VSP_039713 | 67-293 | in isoform 2 | ||
Sequence conflict | 121 | in Ref. 1; BAB21528 | |||
Compositional bias | 177-194 | Polar residues | |||
Sequence conflict | 186 | in Ref. 1; BAB21528 | |||
Compositional bias | 229-248 | Polar residues | |||
Sequence conflict | 241 | in Ref. 4; AAH04034 | |||
Sequence conflict | 263 | in Ref. 4; AAH04034 | |||
Sequence conflict | 266 | in Ref. 4; AAH04034 | |||
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB047544 EMBL· GenBank· DDBJ | BAB21528.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. | |
AK083330 EMBL· GenBank· DDBJ | BAC38868.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. | |
AK144756 EMBL· GenBank· DDBJ | BAE26050.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AK146059 EMBL· GenBank· DDBJ | BAE26868.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. | |
AC109232 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC004034 EMBL· GenBank· DDBJ | AAH04034.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |