Q99KS2 · NGRN_MOUSE

  • Protein
    Neugrin
  • Gene
    Ngrn
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Cellular Componentintercellular bridge
Cellular Componentmitochondrial membrane
Cellular Componentmitotic spindle
Cellular Componentnuclear body
Cellular Componentnucleus
Molecular FunctionrRNA binding
Biological Processcell differentiation
Biological Processmitochondrial ribosome assembly
Biological Processpositive regulation of mitochondrial translation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Neugrin
  • Alternative names
    • FI58Gm
    • Neurite outgrowth-associated protein (m-Neugrin)

Gene names

    • Name
      Ngrn
    • Synonyms
      Fi58g

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • Czech II
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q99KS2
  • Secondary accessions
    • Q8C401
    • Q99PU9

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for signal, chain, modified residue, glycosylation.

Type
IDPosition(s)Description
Signal1-18
ChainPRO_000029448419-293Neugrin
Modified residue41Phosphoserine
Glycosylation185N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in heart, brain, liver and kidney. In brain, mainly expressed in neurons rather than glial cells.

Induction

Highly up-regulated in neuroblastostoma cells by RA and MG132 treatment inducing neurite outgrowth.

Developmental stage

Level of expression increases with embryonal development.

Gene expression databases

Interaction

Subunit

Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for compositional bias, region.

Type
IDPosition(s)Description
Compositional bias177-194Polar residues
Region177-210Disordered
Region224-254Disordered
Compositional bias229-248Polar residues

Sequence similarities

Belongs to the neugrin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 2 isoforms produced by Alternative splicing.

Q99KS2-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    293
  • Mass (Da)
    32,447
  • Last updated
    2010-10-05 v3
  • MD5 Checksum
    F4CC861B981630EB4AA586F061145041
MALSLSLFLGGRVRTSLARCGFASQVMAGPGSVSCEPDPDSDWEPEERELQEVESALKRQKKAMRFQKIRRQMEAPGAPPRTLTWEAMEQIRYLHKEFAESWSVPRLAEGFDVSTDVIRRVLKSKFVPTLEQKLRQDQKVLKKAGFTREIGQLPVSEDTLKALSAGRSVSGLLMAGDEVSSKSQNHSTALKVAKSHPHSTDAQKKREGRDKRIQVLEESLVPATTALGHQRELQKSATSDSEATGRAGSDTLPSAVLLEELKPGEPGDQSFSSKVVQRGHDFFDSNGNFLYRI

Q99KS2-2

  • Name
    2
  • Note
    May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 55-66: SALKRQKKAMRF → RYLLRGEPSAWS
    • 67-293: Missing

Sequence caution

The sequence AAH04034.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence BAB21528.1 differs from that shown. Reason: Frameshift
The sequence BAB21528.1 differs from that shown. Reason: Miscellaneous discrepancy The N-terminus contains a duplicated region of sequence.
The sequence BAC38868.1 differs from that shown. Reason: Erroneous translation Wrong choice of CDS.
The sequence BAE26050.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence BAE26868.1 differs from that shown. Reason: Erroneous translation Wrong choice of CDS.

Features

Showing features for alternative sequence, sequence conflict, compositional bias.

Type
IDPosition(s)Description
Alternative sequenceVSP_03971255-66in isoform 2
Alternative sequenceVSP_03971367-293in isoform 2
Sequence conflict121in Ref. 1; BAB21528
Compositional bias177-194Polar residues
Sequence conflict186in Ref. 1; BAB21528
Compositional bias229-248Polar residues
Sequence conflict241in Ref. 4; AAH04034
Sequence conflict263in Ref. 4; AAH04034
Sequence conflict266in Ref. 4; AAH04034

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB047544
EMBL· GenBank· DDBJ
BAB21528.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
AK083330
EMBL· GenBank· DDBJ
BAC38868.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
AK144756
EMBL· GenBank· DDBJ
BAE26050.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK146059
EMBL· GenBank· DDBJ
BAE26868.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
AC109232
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC004034
EMBL· GenBank· DDBJ
AAH04034.1
EMBL· GenBank· DDBJ
mRNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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