Q99K51 · PLST_MOUSE

  • Protein
    Plastin-3
  • Gene
    Pls3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Actin-bundling protein.

Features

Showing features for binding site.

163050100150200250300350400450500550600
TypeIDPosition(s)Description
Binding site25Ca2+ 1 (UniProtKB | ChEBI)
Binding site27Ca2+ 1 (UniProtKB | ChEBI)
Binding site29Ca2+ 1 (UniProtKB | ChEBI)
Binding site36Ca2+ 1 (UniProtKB | ChEBI)
Binding site65Ca2+ 2 (UniProtKB | ChEBI)
Binding site67Ca2+ 2 (UniProtKB | ChEBI)
Binding site69Ca2+ 2 (UniProtKB | ChEBI)
Binding site71Ca2+ 2 (UniProtKB | ChEBI)
Binding site76Ca2+ 2 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentneuromuscular junction
Molecular Functionactin filament binding
Molecular Functioncalcium ion binding
Molecular Functionstructural constituent of presynaptic actin cytoskeleton
Biological Processactin filament bundle assembly
Biological Processregulation of synaptic vesicle cycle

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Plastin-3
  • Alternative names
    • T-plastin

Gene names

    • Name
      Pls3

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • Czech II
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q99K51
  • Secondary accessions
    • B1AX56
    • Q3TUZ5

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis499When tested in vivo, most C-499 knockin pups die within the first 2 days after birth; they display several phenotypes at late gestation and neonatal time points, including diaphragm abnormalities and anterior body-wall defects.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 31 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000737481-630Plastin-3
Modified residue268Phosphoserine
Modified residue293Phosphoserine
Modified residue326Phosphoserine
Modified residue339Phosphoserine
Modified residue391Phosphothreonine

Keywords

Proteomic databases

PTM databases

Expression

Developmental stage

At 12.5 dpc, expressed in numerous tissues, including the diaphragm, lung mesenchyme and growing edges of the body wall. Observed in face, limbs, tail, and axial skeleton. Also expressed in the lung mesenchyme at 13.5 dpc.

Gene expression databases

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain12-47EF-hand 1
Domain52-87EF-hand 2
Region109-382Actin-binding 1
Domain123-239Calponin-homology (CH) 1
Domain267-378Calponin-homology (CH) 2
Region383-627Actin-binding 2
Domain397-506Calponin-homology (CH) 3
Domain518-627Calponin-homology (CH) 4

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    630
  • Mass (Da)
    70,742
  • Last updated
    2009-04-14 v3
  • Checksum
    FEC5AA91DB963286
MDEMATTQISKDELDELKEAFAKVDLNSNGFICDYELHELFKEANMPLPGYKVREIIQKLMVDGDRNKDGKISFNEFVYIFQEVKSSDIAKTFRKAINRKEGICALGGTSELSSEGTQHSYSEEEKYAFVNWINKALENDPDCRHVIPMNPNTDDLFKAVGDGIVLCKMINLSVPDTIDERAINKKKLTPFIIQENLNLALNSASAIGCHVVNIGAEDLRAGKPHLVLGLLWQIIKIGLFADIELSRNEALAALLRDGETLEELMKLSPEELLLRWANFHLENSGWQKINNFSADIKDSKAYFHLLNQIAPKGQKEGEPRIDINMSGFNETDDLKRAESMLQQADKLGCRQFVTPADVVSGNPKLNLAFVANLFNKYPALTKPENQDIDWTLLEGETREERTFRNWMNSLGVNPHVNHLYADLQDALVILQLYERIKVPVDWSKVNKPPYPKLGANMKKLENCNYAVELGKNPAKFSLVGIGGQDLNDGNPTLTLAVVWQLMRRYTLNVLEDLGEGQKANDDIIVNWVNRTLSEAGKSTSIQSFKDKTISSSLAVVDLIDAIQPGCINYDLVKSGNLTEDDKHNNAKYAVSMARRIGARVYALPEDLVEVKPKMVMTVFACLMGRGMKRV

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1C7CYV0A0A1C7CYV0_MOUSEPls3629
B1AX58B1AX58_MOUSEPls3639

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict391in Ref. 2; BAE35826

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB182243
EMBL· GenBank· DDBJ
BAD23918.1
EMBL· GenBank· DDBJ
mRNA
AK160501
EMBL· GenBank· DDBJ
BAE35826.1
EMBL· GenBank· DDBJ
mRNA
AL805920
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH466576
EMBL· GenBank· DDBJ
EDL29216.1
EMBL· GenBank· DDBJ
Genomic DNA
BC005459
EMBL· GenBank· DDBJ
AAH05459.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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