Q99JG2 · G37L1_MOUSE

  • Protein
    G-protein coupled receptor 37-like 1
  • Gene
    Gpr37l1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

G-protein coupled receptor (PubMed:27072655).
Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (By similarity).
However, other studies have shown that prosaposin does not increase activity (By similarity).
It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (By similarity).
Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (PubMed:24062445).
Regulates baseline blood pressure in females and protects against cardiovascular stress in males (PubMed:29625592).
Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (PubMed:28795439).

Caution

Has been reported to act as a receptor for prosaposin (PSAP). However, it has also been shown that prosaposin does not increase activity. It has been suggested that GPR37L1 is a constitutively active receptor.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentciliary membrane
Cellular Componentplasma membrane
Cellular Componentreceptor complex
Molecular FunctionG protein-coupled peptide receptor activity
Molecular FunctionG protein-coupled receptor activity
Molecular Functionpeptide binding
Biological Processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Biological ProcessBergmann glial cell differentiation
Biological Processcellular response to reactive oxygen species
Biological Processnegative regulation of astrocyte differentiation
Biological Processnegative regulation of neuron differentiation
Biological Processnegative regulation of smoothened signaling pathway
Biological Processnegative regulation of systemic arterial blood pressure
Biological Processpositive regulation of cerebellar granule cell precursor proliferation
Biological Processpositive regulation of MAPK cascade
Biological Processsmoothened signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    G-protein coupled receptor 37-like 1
  • Alternative names
    • Endothelin B receptor-like protein 2 (ETBR-LP-2)

Gene names

    • Name
      Gpr37l1
    • Synonyms
      Etbrlp2

Organism names

  • Taxonomic identifier
  • Strains
    • BALB/cJ
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q99JG2
  • Secondary accessions
    • O88313
    • Q80UB9
    • Q99JG1

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Cell projection, cilium membrane
; Multi-pass membrane protein
Note: Associates with the basal membrane of Bergmann glia cell primary cilia.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain25-134Extracellular
Transmembrane135-155Helical; Name=1
Topological domain156-167Cytoplasmic
Transmembrane168-188Helical; Name=2
Topological domain189-205Extracellular
Transmembrane206-226Helical; Name=3
Topological domain227-251Cytoplasmic
Transmembrane252-272Helical; Name=4
Topological domain273-310Extracellular
Transmembrane311-331Helical; Name=5
Topological domain332-360Cytoplasmic
Transmembrane361-381Helical; Name=6
Topological domain382-398Extracellular
Transmembrane399-419Helical; Name=7
Topological domain420-481Cytoplasmic

Keywords

Phenotypes & Variants

Disruption phenotype

Premature down-regulation of proliferation of cerebellar granule neuron precursors in postnatal mice, precocious maturation of Bergmann glia and Purkinje neurons, precocious juvenile motor abilities, and improved adult motor learning and coordination (PubMed:24062445).
Early activation of the Shh pathway with increased levels of Shh, Smo and Ptch1 earlier in postnatal development than in wild-type mice (PubMed:24062445).
Increased aortic diastolic, mean arterial and pulse pressures in females but not in males (PubMed:29625592).
Males develop exacerbated left ventricular hypertrophy and evidence of heart failure when challenged with short-term angiotensin-2 infusion while females are protected from cardiac fibrosis (PubMed:29625592).
Increased susceptibility to induced seizures (PubMed:28688853).
Reduced signaling in the cerebellum as indicated by significantly less cAMP production (PubMed:27072655).
No effect on the input resistance or resting potential of astrocytes or neurons (PubMed:28795439).
Neuronal death is increased by 40% in an in vitro model of ischemia (PubMed:28795439).

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 22 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond, modified residue.

TypeIDPosition(s)Description
Signal1-24
ChainPRO_000001279725-481G-protein coupled receptor 37-like 1
Glycosylation105N-linked (GlcNAc...) asparagine
Disulfide bond203↔286
Modified residue471Phosphoserine
Modified residue479Phosphothreonine

Post-translational modification

Undergoes metalloprotease-mediated cleavage which reduces its constitutive activity.
Ubiquitinated.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Highly expressed in brain but not in heart or kidney (at protein level) (PubMed:29625592).
In the brain, highly expressed in cerebellar Bergmann glia (at protein level) (PubMed:24062445, PubMed:29625592).
Detected in the hippocampus but not in the brain stem or neocortex (at protein level) (PubMed:29625592).
In several key cardiovascular centers of the central nervous system including the caudal and rostral ventrolateral medulla, the nucleus of the solitary tract, and the A5 nucleus, detected close to, but not within, tyrosine hydroxylase-positive catecholaminergic neurons (at protein level) (PubMed:29625592).
Expressed in astrocytes in both gray and white matter and is also detected throughout the brain in some oligodendrocyte precursors (PubMed:28795439).

Developmental stage

At postnatal day 1, not detectable in any brain area examined but at postnatal day 8, strongly expressed in both astrocytes and oligodendrocyte precursors (OPs). At postnatal day 15 and during adulthood, expression in astrocytes and OPs remains at high levels.

Gene expression databases

Interaction

Subunit

Interacts with the PTCH1 receptor.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region25-55Disordered
Compositional bias38-55Basic and acidic residues
Region75-101Disordered
Compositional bias79-93Polar residues

Domain

The N-terminal region is required for constitutive signal transduction.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    481
  • Mass (Da)
    52,729
  • Last updated
    2005-06-07 v2
  • Checksum
    D7CF26B83B7F6E8C
MRWLWPLAVSLVVVLTVGLSGVSGAATSSLGGHRAKVQEQQSRPRRGTKDEGPKEVQHYVPEEWAEYPKPIHPAGLQPTKTLEATSPNPDKDGATPGNGQELRVNLTGTPSQRLQIQNPLYPVTESSYSAYAIMLLALVVFAVGIVGNLSVMCIVWHSYYLKSAWNSILASLALWDFLVLFFCLPIVIFNEITKQRLLGDVSCRAVPFMEVSSLGVTTFSLCALGIDRFHVATSTLPKVRPIERCQSILAKLAVIWVGSMMLAVPELLLWQLAQEPAPTAGTVDSCIMKPSADLPESVYSLVMTYQNARMWWYFGCYFCLPILFTVTCQLVTWRVRGPPGRKPECRAGRHEQCESQLNSTVVGLTVVYAFCTLPENVCNIVVAYLSTELTRQTLDLLGLINQFSTFFKGAITPVLLLCICRPLGQAFLDCCCCCCCEECGGASDSSATVSADSKLKAEVSSSIYFHKPRESPPLLPLGTPC

Sequence caution

The sequence BAA32062.1 differs from that shown. Reason: Erroneous initiation

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias38-55Basic and acidic residues
Compositional bias79-93Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ306537
EMBL· GenBank· DDBJ
CAC34842.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ306538
EMBL· GenBank· DDBJ
CAC34843.1
EMBL· GenBank· DDBJ
Genomic DNA
AB016602
EMBL· GenBank· DDBJ
BAA32062.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AY255561
EMBL· GenBank· DDBJ
AAO85073.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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