Q99JG2 · G37L1_MOUSE
- ProteinG-protein coupled receptor 37-like 1
- GeneGpr37l1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids481 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
G-protein coupled receptor (PubMed:27072655).
Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (By similarity).
However, other studies have shown that prosaposin does not increase activity (By similarity).
It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (By similarity).
Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (PubMed:24062445).
Regulates baseline blood pressure in females and protects against cardiovascular stress in males (PubMed:29625592).
Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (PubMed:28795439).
Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (By similarity).
However, other studies have shown that prosaposin does not increase activity (By similarity).
It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (By similarity).
Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (PubMed:24062445).
Regulates baseline blood pressure in females and protects against cardiovascular stress in males (PubMed:29625592).
Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (PubMed:28795439).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | ciliary membrane | |
Cellular Component | plasma membrane | |
Cellular Component | receptor complex | |
Molecular Function | G protein-coupled peptide receptor activity | |
Molecular Function | G protein-coupled receptor activity | |
Molecular Function | peptide binding | |
Biological Process | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | |
Biological Process | Bergmann glial cell differentiation | |
Biological Process | cellular response to reactive oxygen species | |
Biological Process | negative regulation of astrocyte differentiation | |
Biological Process | negative regulation of neuron differentiation | |
Biological Process | negative regulation of smoothened signaling pathway | |
Biological Process | negative regulation of systemic arterial blood pressure | |
Biological Process | positive regulation of cerebellar granule cell precursor proliferation | |
Biological Process | positive regulation of MAPK cascade | |
Biological Process | smoothened signaling pathway |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameG-protein coupled receptor 37-like 1
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ99JG2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Cell projection, cilium membrane ; Multi-pass membrane protein
Note: Associates with the basal membrane of Bergmann glia cell primary cilia.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 25-134 | Extracellular | ||||
Sequence: AATSSLGGHRAKVQEQQSRPRRGTKDEGPKEVQHYVPEEWAEYPKPIHPAGLQPTKTLEATSPNPDKDGATPGNGQELRVNLTGTPSQRLQIQNPLYPVTESSYSAYAIM | ||||||
Transmembrane | 135-155 | Helical; Name=1 | ||||
Sequence: LLALVVFAVGIVGNLSVMCIV | ||||||
Topological domain | 156-167 | Cytoplasmic | ||||
Sequence: WHSYYLKSAWNS | ||||||
Transmembrane | 168-188 | Helical; Name=2 | ||||
Sequence: ILASLALWDFLVLFFCLPIVI | ||||||
Topological domain | 189-205 | Extracellular | ||||
Sequence: FNEITKQRLLGDVSCRA | ||||||
Transmembrane | 206-226 | Helical; Name=3 | ||||
Sequence: VPFMEVSSLGVTTFSLCALGI | ||||||
Topological domain | 227-251 | Cytoplasmic | ||||
Sequence: DRFHVATSTLPKVRPIERCQSILAK | ||||||
Transmembrane | 252-272 | Helical; Name=4 | ||||
Sequence: LAVIWVGSMMLAVPELLLWQL | ||||||
Topological domain | 273-310 | Extracellular | ||||
Sequence: AQEPAPTAGTVDSCIMKPSADLPESVYSLVMTYQNARM | ||||||
Transmembrane | 311-331 | Helical; Name=5 | ||||
Sequence: WWYFGCYFCLPILFTVTCQLV | ||||||
Topological domain | 332-360 | Cytoplasmic | ||||
Sequence: TWRVRGPPGRKPECRAGRHEQCESQLNST | ||||||
Transmembrane | 361-381 | Helical; Name=6 | ||||
Sequence: VVGLTVVYAFCTLPENVCNIV | ||||||
Topological domain | 382-398 | Extracellular | ||||
Sequence: VAYLSTELTRQTLDLLG | ||||||
Transmembrane | 399-419 | Helical; Name=7 | ||||
Sequence: LINQFSTFFKGAITPVLLLCI | ||||||
Topological domain | 420-481 | Cytoplasmic | ||||
Sequence: CRPLGQAFLDCCCCCCCEECGGASDSSATVSADSKLKAEVSSSIYFHKPRESPPLLPLGTPC |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Premature down-regulation of proliferation of cerebellar granule neuron precursors in postnatal mice, precocious maturation of Bergmann glia and Purkinje neurons, precocious juvenile motor abilities, and improved adult motor learning and coordination (PubMed:24062445).
Early activation of the Shh pathway with increased levels of Shh, Smo and Ptch1 earlier in postnatal development than in wild-type mice (PubMed:24062445).
Increased aortic diastolic, mean arterial and pulse pressures in females but not in males (PubMed:29625592).
Males develop exacerbated left ventricular hypertrophy and evidence of heart failure when challenged with short-term angiotensin-2 infusion while females are protected from cardiac fibrosis (PubMed:29625592).
Increased susceptibility to induced seizures (PubMed:28688853).
Reduced signaling in the cerebellum as indicated by significantly less cAMP production (PubMed:27072655).
No effect on the input resistance or resting potential of astrocytes or neurons (PubMed:28795439).
Neuronal death is increased by 40% in an in vitro model of ischemia (PubMed:28795439).
Early activation of the Shh pathway with increased levels of Shh, Smo and Ptch1 earlier in postnatal development than in wild-type mice (PubMed:24062445).
Increased aortic diastolic, mean arterial and pulse pressures in females but not in males (PubMed:29625592).
Males develop exacerbated left ventricular hypertrophy and evidence of heart failure when challenged with short-term angiotensin-2 infusion while females are protected from cardiac fibrosis (PubMed:29625592).
Increased susceptibility to induced seizures (PubMed:28688853).
Reduced signaling in the cerebellum as indicated by significantly less cAMP production (PubMed:27072655).
No effect on the input resistance or resting potential of astrocytes or neurons (PubMed:28795439).
Neuronal death is increased by 40% in an in vitro model of ischemia (PubMed:28795439).
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 22 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for signal, chain, glycosylation, disulfide bond, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-24 | |||||
Sequence: MRWLWPLAVSLVVVLTVGLSGVSG | ||||||
Chain | PRO_0000012797 | 25-481 | G-protein coupled receptor 37-like 1 | |||
Sequence: AATSSLGGHRAKVQEQQSRPRRGTKDEGPKEVQHYVPEEWAEYPKPIHPAGLQPTKTLEATSPNPDKDGATPGNGQELRVNLTGTPSQRLQIQNPLYPVTESSYSAYAIMLLALVVFAVGIVGNLSVMCIVWHSYYLKSAWNSILASLALWDFLVLFFCLPIVIFNEITKQRLLGDVSCRAVPFMEVSSLGVTTFSLCALGIDRFHVATSTLPKVRPIERCQSILAKLAVIWVGSMMLAVPELLLWQLAQEPAPTAGTVDSCIMKPSADLPESVYSLVMTYQNARMWWYFGCYFCLPILFTVTCQLVTWRVRGPPGRKPECRAGRHEQCESQLNSTVVGLTVVYAFCTLPENVCNIVVAYLSTELTRQTLDLLGLINQFSTFFKGAITPVLLLCICRPLGQAFLDCCCCCCCEECGGASDSSATVSADSKLKAEVSSSIYFHKPRESPPLLPLGTPC | ||||||
Glycosylation | 105 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 203↔286 | |||||
Sequence: CRAVPFMEVSSLGVTTFSLCALGIDRFHVATSTLPKVRPIERCQSILAKLAVIWVGSMMLAVPELLLWQLAQEPAPTAGTVDSC | ||||||
Modified residue | 471 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 479 | Phosphothreonine | ||||
Sequence: T |
Post-translational modification
Undergoes metalloprotease-mediated cleavage which reduces its constitutive activity.
Ubiquitinated.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Highly expressed in brain but not in heart or kidney (at protein level) (PubMed:29625592).
In the brain, highly expressed in cerebellar Bergmann glia (at protein level) (PubMed:24062445, PubMed:29625592).
Detected in the hippocampus but not in the brain stem or neocortex (at protein level) (PubMed:29625592).
In several key cardiovascular centers of the central nervous system including the caudal and rostral ventrolateral medulla, the nucleus of the solitary tract, and the A5 nucleus, detected close to, but not within, tyrosine hydroxylase-positive catecholaminergic neurons (at protein level) (PubMed:29625592).
Expressed in astrocytes in both gray and white matter and is also detected throughout the brain in some oligodendrocyte precursors (PubMed:28795439).
In the brain, highly expressed in cerebellar Bergmann glia (at protein level) (PubMed:24062445, PubMed:29625592).
Detected in the hippocampus but not in the brain stem or neocortex (at protein level) (PubMed:29625592).
In several key cardiovascular centers of the central nervous system including the caudal and rostral ventrolateral medulla, the nucleus of the solitary tract, and the A5 nucleus, detected close to, but not within, tyrosine hydroxylase-positive catecholaminergic neurons (at protein level) (PubMed:29625592).
Expressed in astrocytes in both gray and white matter and is also detected throughout the brain in some oligodendrocyte precursors (PubMed:28795439).
Developmental stage
At postnatal day 1, not detectable in any brain area examined but at postnatal day 8, strongly expressed in both astrocytes and oligodendrocyte precursors (OPs). At postnatal day 15 and during adulthood, expression in astrocytes and OPs remains at high levels.
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 25-55 | Disordered | ||||
Sequence: AATSSLGGHRAKVQEQQSRPRRGTKDEGPKE | ||||||
Compositional bias | 38-55 | Basic and acidic residues | ||||
Sequence: QEQQSRPRRGTKDEGPKE | ||||||
Region | 75-101 | Disordered | ||||
Sequence: GLQPTKTLEATSPNPDKDGATPGNGQE | ||||||
Compositional bias | 79-93 | Polar residues | ||||
Sequence: TKTLEATSPNPDKDG |
Domain
The N-terminal region is required for constitutive signal transduction.
Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length481
- Mass (Da)52,729
- Last updated2005-06-07 v2
- ChecksumD7CF26B83B7F6E8C
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 38-55 | Basic and acidic residues | ||||
Sequence: QEQQSRPRRGTKDEGPKE | ||||||
Compositional bias | 79-93 | Polar residues | ||||
Sequence: TKTLEATSPNPDKDG |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ306537 EMBL· GenBank· DDBJ | CAC34842.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ306538 EMBL· GenBank· DDBJ | CAC34843.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB016602 EMBL· GenBank· DDBJ | BAA32062.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AY255561 EMBL· GenBank· DDBJ | AAO85073.1 EMBL· GenBank· DDBJ | mRNA |