Q99AU2 · Q99AU2_9HEPC
- ProteinGenome polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids3010 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
Cofactor
Protein has several cofactor binding sites:
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 1123 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 1125 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 1171 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 1175 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 1233 | ADP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 1234 | ADP (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 1235 | ADP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 1236 | ADP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 1237 | ADP (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 1237 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 1237 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 1238 | ADP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 1267 | ADP (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 1316 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 1317 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 1317 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 1493 | ADP (UniProtKB | ChEBI) | ||||
Sequence: R |
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Hepacivirus > Hepacivirus hominis
Accessions
- Primary accessionQ99AU2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Endoplasmic reticulum membrane ; Peripheral membrane protein
Endoplasmic reticulum membrane ; Single-pass membrane protein
Endoplasmic reticulum membrane ; Single-pass type I membrane protein
Host endoplasmic reticulum membrane ; Multi-pass membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Host endoplasmic reticulum membrane ; Single-pass membrane protein
Host endoplasmic reticulum membrane ; Single-pass type I membrane protein
Host mitochondrion membrane ; Single-pass type I membrane protein
Membrane ; Multi-pass membrane protein
Membrane ; Peripheral membrane protein
Membrane ; Single-pass membrane protein
Membrane ; Single-pass type I membrane protein
Mitochondrion membrane ; Single-pass type I membrane protein
Virion membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 718-740 | Helical | ||||
Sequence: YVLLLFLLLADARVCACLWMMLL | ||||||
Transmembrane | 752-778 | Helical | ||||
Sequence: VVLNAASVAGAHGLLSFLVFFCAAWYI | ||||||
Transmembrane | 784-803 | Helical | ||||
Sequence: PGAAYALYGVWPLLLLLLAL | ||||||
Transmembrane | 815-835 | Helical | ||||
Sequence: AASCGGAVFVGLVLLTLSPYY | ||||||
Transmembrane | 1660-1688 | Helical | ||||
Sequence: WVLVGGVLAALAAYCLTTGSVVIVGRIIL | ||||||
Transmembrane | 1825-1845 | Helical | ||||
Sequence: AASAFVGAGIAGAAVGSIGLG | ||||||
Transmembrane | 1851-1870 | Helical | ||||
Sequence: ILAGYGAGVAGALVAFKVMS | ||||||
Transmembrane | 1882-1902 | Helical | ||||
Sequence: LLPAILSPGALVVGVVCAAIL | ||||||
Transmembrane | 2990-3007 | Helical | ||||
Sequence: WFMLCLLLLSVGVGIYLL |
Keywords
- Cellular component
Phenotypes & Variants
Chemistry
PTM/Processing
Features
Showing features for disulfide bond, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 1123↔1171 | |||||
Sequence: CTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLC | ||||||
Modified residue | 2642 | Cysteine sulfinic acid (-SO2H) | ||||
Sequence: C | ||||||
Disulfide bond | 2722↔2730 | |||||
Sequence: CRAAKLQDC |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-78 | Disordered | ||||
Sequence: MSTNPKPQRKTKRNTNRRPQDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRGRRQPIPKARRPEGRTWAQ | ||||||
Compositional bias | 47-69 | Basic and acidic residues | ||||
Sequence: RATRKTSERSQPRGRRQPIPKAR | ||||||
Domain | 903-1026 | Peptidase C18 | ||||
Sequence: QAGITRVPYFVRAQGLIHACMLVRKVAGGHYVQMAFMKLGALTGTYIYNHLTPLRDWAHAGLRDLAVAVEPVVFSDMETKIITWGADTAACGDIILGLPVSARRGKEILLGPADSLEGRGWRLL | ||||||
Domain | 1027-1208 | Peptidase S29 | ||||
Sequence: APITAYSQQTRGLLGCIITSLTGRDKNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRSP | ||||||
Domain | 1217-1369 | Helicase ATP-binding | ||||
Sequence: PAVPQSFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGIDPNIRTGVRTITTGAPVTYSTYGKFLADGGCSGGAYDIIICDECHSTDSTTILGIGTVLDQAETAGARLVVLATATPPGSVTVPHPNIEEVALSN | ||||||
Domain | 1361-1538 | Helicase C-terminal | ||||
Sequence: NIEEVALSNTGEIPFYGKAIPIEAIRGGRHLIFCHSKKKCDELAAKLSGLGINAVAYYRGLDVSVIPTIGDVVVVATDALMTGYTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTVPQDAVSRSQRRGRTGRGRRGIYRFVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETSVR | ||||||
Compositional bias | 2351-2369 | Polar residues | ||||
Sequence: TFGSSESSAVDSGTATALP | ||||||
Region | 2351-2407 | Disordered | ||||
Sequence: TFGSSESSAVDSGTATALPDQASDDGDKGSDVESYSSMPPLEGEPGDPDLSDGSWST | ||||||
Domain | 2633-2751 | RdRp catalytic | ||||
Sequence: PMGFSYDTRCFDSTVTENDIRVEESIYQCCDLAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKASAACRAAKLQDCTMLVNGDDLVVICESAGTQED |
Sequence similarities
Belongs to the hepacivirus polyprotein family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length3,010
- Mass (Da)327,011
- Last updated2001-06-01 v1
- Checksum053B9A653B0AB335
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 47-69 | Basic and acidic residues | ||||
Sequence: RATRKTSERSQPRGRRQPIPKAR | ||||||
Compositional bias | 2351-2369 | Polar residues | ||||
Sequence: TFGSSESSAVDSGTATALP |
Keywords
- Technical term