Q99942 · RNF5_HUMAN
- ProteinE3 ubiquitin-protein ligase RNF5
- GeneRNF5
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids180 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Membrane-bound E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins (PubMed:11329381, PubMed:12861019, PubMed:16176924, PubMed:19269966, PubMed:19285439).
May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4 (PubMed:11329381).
Mediates ubiquitination of PXN/paxillin,thereby regulating cell motility and localization of PXN/paxillin (PubMed:12861019).
Catalyzes ubiquitination of Salmonella type III secreted protein sopA (PubMed:16176924).
Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N (PubMed:19269966).
Mediates the 'Lys-48'-linked polyubiquitination of STING1 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses (PubMed:19285439).
Catalyzes ubiquitination and subsequent degradation of ATG4B, thereby inhibiting autophagy (PubMed:23093945).
May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4 (PubMed:11329381).
Mediates ubiquitination of PXN/paxillin,thereby regulating cell motility and localization of PXN/paxillin (PubMed:12861019).
Catalyzes ubiquitination of Salmonella type III secreted protein sopA (PubMed:16176924).
Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N (PubMed:19269966).
Mediates the 'Lys-48'-linked polyubiquitination of STING1 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses (PubMed:19285439).
Catalyzes ubiquitination and subsequent degradation of ATG4B, thereby inhibiting autophagy (PubMed:23093945).
Catalytic activity
Pathway
Protein modification; protein ubiquitination.
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameE3 ubiquitin-protein ligase RNF5
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ99942
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Mitochondrion membrane ; Multi-pass membrane protein
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Note: Predominantly located in the plasma membrane, with some localization occurring within cytoplasmic organelles.
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 118-138 | Helical | ||||
Sequence: GGFHFSFGVGAFPFGFFTTVF | ||||||
Transmembrane | 160-180 | Helical | ||||
Sequence: SWQDSLFLFLAIFFFFWLLSI |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 42 | Loss of E3 ubiquitin-protein ligase activity. | ||||
Sequence: C → S |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 313 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Initiator methionine | 1 | UniProt | Removed | ||||
Sequence: M | |||||||
Modified residue | 2 | UniProt | N-acetylalanine | ||||
Sequence: A | |||||||
Chain | PRO_0000240393 | 2-180 | UniProt | E3 ubiquitin-protein ligase RNF5 | |||
Sequence: AAAEEEDGGPEGPNRERGGAGATFECNICLETAREAVVSVCGHLYCWPCLHQWLETRPERQECPVCKAGISREKVVPLYGRGSQKPQDPRLKTPPRPQGQRPAPESRGGFQPFGDTGGFHFSFGVGAFPFGFFTTVFNAHEPFRRGTGVDLGQGHPASSWQDSLFLFLAIFFFFWLLSI | |||||||
Modified residue | 84 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 94 | UniProt | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 94 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue | 107 | UniProt | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Widely expressed.
Gene expression databases
Organism-specific databases
Interaction
Subunit
Interacts with PXN (PubMed:12861019).
Interacts with Salmonella typhimurium sopA (PubMed:12861019).
Interacts with JKAMP (PubMed:19269966).
Interacts with STING1; the interaction of endogenous proteins is dependent on viral infection (PubMed:19285439).
Interacts with Salmonella typhimurium sopA (PubMed:12861019).
Interacts with JKAMP (PubMed:19269966).
Interacts with STING1; the interaction of endogenous proteins is dependent on viral infection (PubMed:19285439).
Binary interactions
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for zinc finger, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Zinc finger | 27-68 | RING-type | ||||
Sequence: CNICLETAREAVVSVCGHLYCWPCLHQWLETRPERQECPVCK | ||||||
Region | 79-110 | Disordered | ||||
Sequence: LYGRGSQKPQDPRLKTPPRPQGQRPAPESRGG |
Sequence similarities
Belongs to the RNF5 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length180
- Mass (Da)19,881
- Last updated1997-05-01 v1
- ChecksumE5AFA4DE6DE85942
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A140TA09 | A0A140TA09_HUMAN | RNF5 | 91 |
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 22 | in Ref. 3; CAB51286 | ||||
Sequence: G → S | ||||||
Sequence conflict | 60 | in Ref. 3; CAB51286 | ||||
Sequence: E → D | ||||||
Sequence conflict | 117 | in Ref. 3; CAB51286 | ||||
Sequence: T → A | ||||||
Sequence conflict | 148 | in Ref. 3; CAB51286 | ||||
Sequence: T → A |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB056869 EMBL· GenBank· DDBJ | BAB39359.1 EMBL· GenBank· DDBJ | mRNA | ||
AJ243936 EMBL· GenBank· DDBJ | CAB51286.1 EMBL· GenBank· DDBJ | mRNA | ||
AK311859 EMBL· GenBank· DDBJ | BAG34800.1 EMBL· GenBank· DDBJ | mRNA | ||
BT007105 EMBL· GenBank· DDBJ | AAP35769.1 EMBL· GenBank· DDBJ | mRNA | ||
U89336 EMBL· GenBank· DDBJ | AAB47492.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL845464 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL662884 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL662830 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BX284686 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BX927239 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CR812478 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CR933878 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC004155 EMBL· GenBank· DDBJ | AAH04155.1 EMBL· GenBank· DDBJ | mRNA | ||
BC111392 EMBL· GenBank· DDBJ | AAI11393.1 EMBL· GenBank· DDBJ | mRNA | ||
BC119741 EMBL· GenBank· DDBJ | AAI19742.1 EMBL· GenBank· DDBJ | mRNA | ||
BC119742 EMBL· GenBank· DDBJ | AAI19743.1 EMBL· GenBank· DDBJ | mRNA | ||
BC127651 EMBL· GenBank· DDBJ | AAI27652.1 EMBL· GenBank· DDBJ | mRNA | ||
BC127652 EMBL· GenBank· DDBJ | AAI27653.1 EMBL· GenBank· DDBJ | mRNA | ||
BC148255 EMBL· GenBank· DDBJ | AAI48256.1 EMBL· GenBank· DDBJ | mRNA |