Human chromosome 7: DNA sequence and biology.Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J.[...], Tsui L.-C.View abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]CategorySequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCScience 300:767-772 (2003)Cited in99+99+
No title available.Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H.[...], Venter J.C.Cited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]CategorySequencesSourceUniProtKB reviewed (Swiss-Prot)Submission Submitted to EMBL/GenBank/DDBJ databases (JUL-2005)Cited in99+99+
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project TeamView abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]TissueBrainCategorySequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGenome Res. 14:2121-2127 (2004)Cited in99+99+
The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development.Endoh-Yamagami S., Evangelista M., Wilson D., Wen X., Theunissen J.W., Phamluong K., Davis M., Scales S.J., Solloway M.J.[...], Peterson A.S.View abstractCited forFUNCTION, INTERACTION WITH KIF7CategoriesFunction, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCurr. Biol. 19:1320-1326 (2009)Cited in7Mapped to71
A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened.Seo S., Zhang Q., Bugge K., Breslow D.K., Searby C.C., Nachury M.V., Sheffield V.C.View abstractCited forASSOCIATION WITH THE BBSOME COMPLEX, INTERACTION WITH BBS5 AND BBS7, SUBCELLULAR LOCATIONCategoriesInteraction, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCPLoS Genet. 7:E1002358-E1002358 (2011)Cited in18Mapped to47
Mapping the O-glycoproteome using site-specific extraction of O-linked glycopeptides (EXoO).Yang W., Ao M., Hu Y., Li Q.K., Zhang H.View abstractCategoryPTM / ProcessingSourcePRO: PR:000057980, PRO: PR:000057981PubMedEurope PMCMol Syst Biol 14:e8486-e8486 (2018)Mapped to99+
Site-Specific Profiling of Serum Glycoproteins Using N-Linked Glycan and Glycosite Analysis Revealing Atypical N-Glycosylation Sites on Albumin and alpha-1B-Glycoprotein.Sun S., Hu Y., Jia L., Eshghi S.T., Liu Y., Shah P., Zhang H.View abstractCategoryPTM / ProcessingSourcePRO: PR:000057979PubMedEurope PMCAnal Chem 90:6292-6299 (2018)Mapped to99+
Dual MET and SMO Negative Modulators Overcome Resistance to EGFR Inhibitors in Human Nonsmall Cell Lung Cancer.Morgillo F., Amendola G., Della Corte C.M., Giacomelli C., Botta L., Di Maro S., Messere A., Ciaramella V., Taliani S.[...], Cosconati S.View abstractAnnotationDual MET and SMO Inhibitors are potent antiproliferative agents in EGFR-Tyrosine kinase inhibitors resistant human non small cell lung cancer.CategoryFunctionSourceGeneRif: 6608PubMedEurope PMCJ Med Chem 60:7447-7458 (2017)Mapped to70
Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling.Xiao X., Tang J.J., Peng C., Wang Y., Fu L., Qiu Z.P., Xiong Y., Yang L.F., Cui H.W.[...], Song B.L.View abstractAnnotationSMO is covalently modified by cholesterol. This modification is regulated by Ptch1 and Hh and is essential for Hh signaling.CategoriesFunction, Disease & VariantsSourceGeneRif: 6608PubMedEurope PMCMol Cell 66:154-162.e10 (2017)Mapped to53
The intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3.Liew G.M., Ye F., Nager A.R., Murphy J.P., Lee J.S., Aguiar M., Breslow D.K., Gygi S.P., Nachury M.V.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-445121PubMedEurope PMCDev. Cell 31:265-278 (2014)Cited in2Mapped to99+
Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover.Huang S., Zhang Z., Zhang C., Lv X., Zheng X., Chen Z., Sun L., Wang H., Zhu Y.[...], Chen D.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-5610419, Reactome: R-HSA-5610422PubMedEurope PMCPLoS Biol 11:e1001721-e1001721 (2013)Mapped to99+
The roles of evolutionarily conserved functional modules in cilia-related trafficking.Sung C.H., Leroux M.R.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-445121, Reactome: R-HSA-5624094PubMedEurope PMCNat Cell Biol 15:1387-1397 (2013)Mapped to91
The mechanisms of Hedgehog signalling and its roles in development and disease.Briscoe J., Therond P.P.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-5610419, Reactome: R-HSA-5610422, Reactome: R-HSA-5624094, Reactome: R-HSA-5632525, Reactome: R-HSA-5632528PubMedEurope PMCNat Rev Mol Cell Biol 14:416-429 (2013)Mapped to65
The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic Hedgehog pathway via cAMP signaling.Mukhopadhyay S., Wen X., Ratti N., Loktev A., Rangell L., Scales S.J., Jackson P.K.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-5632528PubMedEurope PMCCell 152:210-223 (2013)Cited in1Mapped to99+
The ciliary Evc/Evc2 complex interacts with Smo and controls Hedgehog pathway activity in chondrocytes by regulating Sufu/Gli3 dissociation and Gli3 trafficking in primary cilia.Caparros-Martin J.A., Valencia M., Reytor E., Pacheco M., Fernandez M., Perez-Aytes A., Gean E., Lapunzina P., Peters H.[...], Ruiz-Perez V.L.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-5610422, Reactome: R-HSA-5624094, Reactome: R-HSA-5632528PubMedEurope PMCHum Mol Genet 22:124-139 (2013)Mapped to96
Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS- associated phenotypes and Bbs3 unique phenotypes.Zhang Q., Nishimura D., Seo S., Vogel T., Morgan D.A., Searby C., Bugge K., Stone E.M., Rahmouni K., Sheffield V.C.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-445121, Reactome: R-HSA-5624094PubMedEurope PMCProc Natl Acad Sci U S A 108:20678-20683 (2011)Mapped to71
Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube.Tuson M., He M., Anderson K.V.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-5610419, Reactome: R-HSA-5610422, Reactome: R-HSA-5632528PubMedEurope PMCDevelopment 138:4921-4930 (2011)Mapped to99+
A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes.Tukachinsky H., Lopez L.V., Salic A.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-5632528PubMedEurope PMCJ Cell Biol 191:415-428 (2010)Mapped to99+
TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.Mukhopadhyay S., Wen X., Chih B., Nelson C.D., Lane W.S., Scales S.J., Jackson P.K.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-5632528PubMedEurope PMCGenes Dev. 24:2180-2193 (2010)Cited in7Mapped to91
MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.Zhang X., Yang H., Lee J.J., Kim E., Lippman S.M., Khuri F.R., Spitz M.R., Lotan R., Hong W.K., Wu X.View abstractAnnotationObservational study of gene-disease association and gene-gene interaction. (HuGE Navigator)CategoriesSequences, Disease & VariantsSourceGeneRif: 6608PubMedEurope PMCCarcinogenesis 31:2118-2123 (2010)Mapped to99+
The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia.Jin H., White S.R., Shida T., Schulz S., Aguiar M., Gygi S.P., Bazan J.F., Nachury M.V.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-445121, Reactome: R-HSA-5624094PubMedEurope PMCCell 141:1208-1219 (2010)Cited in2Mapped to72
The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins.Humke E.W., Dorn K.V., Milenkovic L., Scott M.P., Rohatgi R.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-5632528PubMedEurope PMCGenes Dev. 24:670-682 (2010)Cited in2Mapped to71
Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation.Wen X., Lai C.K., Evangelista M., Hongo J.A., de Sauvage F.J., Scales S.J.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-5632528PubMedEurope PMCMol Cell Biol 30:1910-1922 (2010)Mapped to97
Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin.Rittie L., Stoll S.W., Kang S., Voorhees J.J., Fisher G.J.View abstractAnnotationSMO is preferentially expressed by human bulge cells compared to differentiated hair follicle keratinocytesCategoryExpressionSourceGeneRif: 6608PubMedEurope PMCAging Cell 8:738-751 (2009)Mapped to72
The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.Landa I., Ruiz-Llorente S., Montero-Conde C., Inglada-Perez L., Schiavi F., Leskela S., Pita G., Milne R., Maravall J.[...], Robledo M.View abstractAnnotationNot Associated with CANCER: thyroid cancer., Observational study of gene-disease association. (HuGE Navigator)CategoryDisease & VariantsSourceGAD:558787, GeneRif: 6608PubMedEurope PMCPLoS Genet 5:e1000637-e1000637 (2009)Mapped to99+