The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog.Stone D.M., Hynes M., Armanini M., Swanson T.A., Gu Q., Johnson R.L., Scott M.P., Pennica D., Goddard A.[...], Rosenthal A.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA]TissueEmbryonic lungCategorySequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNature 384:129-134 (1996)Cited in2Mapped to32
Activating Smoothened mutations in sporadic basal-cell carcinoma.Xie J., Murone M., Luoh S.-M., Ryan A., Gu Q., Zhang C., Bonifas J.M., Lam C.-W., Hynes M.[...], de Sauvage F.J.View abstractCited forNUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LEU-535 AND GLN-562CategorySequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNature 391:90-92 (1998)Cited in1
Cloning and identification of Gx gene in NPC.Jiang N., Zeng Z.Y., Li G.Y.Cited forNUCLEOTIDE SEQUENCE [MRNA]CategorySequencesSourceUniProtKB reviewed (Swiss-Prot)Submission Submitted to EMBL/GenBank/DDBJ databases (JAN-1999)Cited in1
Human chromosome 7: DNA sequence and biology.Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J.[...], Tsui L.-C.View abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]CategorySequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCScience 300:767-772 (2003)Cited in99+99+
No title available.Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H.[...], Venter J.C.Cited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]CategorySequencesSourceUniProtKB reviewed (Swiss-Prot)Submission Submitted to EMBL/GenBank/DDBJ databases (JUL-2005)Cited in99+99+
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project TeamView abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]TissueBrainCategorySequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGenome Res. 14:2121-2127 (2004)Cited in99+99+
The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development.Endoh-Yamagami S., Evangelista M., Wilson D., Wen X., Theunissen J.W., Phamluong K., Davis M., Scales S.J., Solloway M.J.[...], Peterson A.S.View abstractCited forFUNCTION, INTERACTION WITH KIF7CategoriesFunction, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCurr. Biol. 19:1320-1326 (2009)Cited in7Mapped to71
Growth arrest specific 8 (Gas8) and G protein-coupled receptor kinase 2 (GRK2) cooperate in the control of Smoothened signaling.Evron T., Philipp M., Lu J., Meloni A.R., Burkhalter M., Chen W., Caron M.G.View abstractCited forINTERACTION WITH GAS8CategoryInteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 286:27676-27686 (2011)Cited in61Mapped to39
A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened.Seo S., Zhang Q., Bugge K., Breslow D.K., Searby C.C., Nachury M.V., Sheffield V.C.View abstractCited forASSOCIATION WITH THE BBSOME COMPLEX, INTERACTION WITH BBS5 AND BBS7, SUBCELLULAR LOCATIONCategoriesInteraction, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCPLoS Genet. 7:E1002358-E1002358 (2011)Cited in18Mapped to47
A recurrent mosaic mutation in SMO, encoding the hedgehog signal transducer smoothened, is the major cause of Curry-Jones syndrome.Twigg S.R., Hufnagel R.B., Miller K.A., Zhou Y., McGowan S.J., Taylor J., Craft J., Taylor J.C., Santoro S.L.[...], Wilkie A.O.View abstractCited forINVOLVEMENT IN CRJS, VARIANT CRJS PHE-412CategoriesSequences, Disease & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCAm. J. Hum. Genet. 98:1256-1265 (2016)Cited in1Mapped to3
Structure of the human smoothened receptor bound to an antitumour agent.Wang C., Wu H., Katritch V., Han G.W., Huang X.P., Liu W., Siu F.Y., Roth B.L., Cherezov V., Stevens R.C.View abstractCited forX-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 190-555 IN COMPLEX WITH ANTAGONIST, SUBUNIT, DISULFIDE BONDSCategoriesPTM / Processing, Interaction, StructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNature 497:338-343 (2013)Cited in1Mapped to4
Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain.Kinnebrew M., Woolley R.E., Ansell T.B., Byrne E.F.X., Frigui S., Luchetti G., Sircar R., Nachtergaele S., Mydock-McGrane L.[...], Rohatgi R.View abstractCited forX-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 32-555 OF MUTANT PHE-329 IN COMPLEX WITH CHOLESTEROL, DOMAIN, DISULFIDE BONDSCategoriesFamily & Domains, PTM / Processing, Disease & Variants, Interaction, StructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCSci. Adv. 8:eabm5563-eabm5563 (2022)Cited in2Mapped to1
Identification of recurrent SMO and BRAF mutations in ameloblastomas.Sweeney R.T., McClary A.C., Myers B.R., Biscocho J., Neahring L., Kwei K.A., Qu K., Gong X., Ng T.[...], West R.B.View abstractCited forVARIANT CRJS PHE-412, VARIANT LEU-535, CHARACTERIZATION OF VARIANT CRJS PHE-412, CHARACTERIZATION OF VARIANT LEU-535CategorySequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNat. Genet. 46:722-725 (2014)Cited in1Mapped to4
Implicating clinical utility of altered expression of PTCH1 & SMO in oral squamous cell carcinoma.Patel H.V., Joshi J.S., Shah F.D.View abstractAnnotationImplicating clinical utility of altered expression of PTCH1 & SMO in oral squamous cell carcinoma.SourceGeneRif: 6608PubMedEurope PMCJ Mol Histol 55:379-389 (2024)Mapped to19
HERC4 modulates ovarian cancer cell proliferation by regulating SMO- elicited hedgehog signaling.Zhu Q., Yang X., Lv Y.View abstractAnnotationHERC4 modulates ovarian cancer cell proliferation by regulating SMO-elicited hedgehog signaling.CategoryFunctionSourceGeneRif: 6608PubMedEurope PMCBiochim Biophys Acta Gen Subj 1868:130557-130557 (2024)Mapped to7
Increasing Ciliary ARL13B Expression Drives Active and Inhibitor-Resistant Smoothened and GLI into Glioma Primary Cilia.Shi P., Tian J., Mallinger J.C., Ling D., Deleyrolle L.P., McIntyre J.C., Caspary T., Breunig J.J., Sarkisian M.R.View abstractAnnotationIncreasing Ciliary ARL13B Expression Drives Active and Inhibitor-Resistant Smoothened and GLI into Glioma Primary Cilia.CategoryPTM / ProcessingSourceGeneRif: 6608PubMedEurope PMCCells 12:2354-2354 (2023)Mapped to9
Genetic Study of <i>BRAF</i> V600E and <i>SMO</i> L412F Mutations in Japanese Patients with Ameloblastoma.Kokubun K., Yamamoto K., Akashi Y., Chujo T., Nakajima K., Matsuzaka K.View abstractAnnotationGenetic Study of BRAF V600E and SMO L412F Mutations in Japanese Patients with Ameloblastoma.CategorySequencesSourceGeneRif: 6608PubMedEurope PMCInt J Surg Pathol 30:378-384 (2022)Mapped to5
Smoothened (SMO) regulates insulin-like growth factor 1 receptor (IGF1R) levels and protein kinase B (AKT) localization and signaling.Agarwal N.K., Kim C.H., Kunkalla K., Vaghefi A., Sanchez S., Manuel S., Bilbao D., Vega F., Landgraf R.View abstractAnnotationSmoothened (SMO) regulates insulin-like growth factor 1 receptor (IGF1R) levels and protein kinase B (AKT) localization and signaling.CategoriesFunction, Subcellular LocationSourceGeneRif: 6608PubMedEurope PMCLab Invest 102:401-410 (2022)Mapped to4
Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes.Kinnebrew M., Luchetti G., Sircar R., Frigui S., Viti L.V., Naito T., Beckert F., Saheki Y., Siebold C.[...], Rohatgi R.View abstractAnnotationPatched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes.CategoryFunctionSourceGeneRif: 6608PubMedEurope PMCElife 10:e70504-e70504 (2021)Mapped to19
Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits.Arveseth C.D., Happ J.T., Hedeen D.S., Zhu J.F., Capener J.L., Klatt Shaw D., Deshpande I., Liang J., Xu J.[...], Myers B.R.View abstractAnnotationSmoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits.CategoriesFunction, PTM / ProcessingSourceGeneRif: 6608PubMedEurope PMCPLoS Biol. 19:e3001191-e3001191 (2021)Cited in2Mapped to8
MIRLET7BHG promotes hepatocellular carcinoma progression by activating hepatic stellate cells through exosomal SMO to trigger Hedgehog pathway.Xia Y., Zhen L., Li H., Wang S., Chen S., Wang C., Yang X.View abstractAnnotationMIRLET7BHG promotes hepatocellular carcinoma progression by activating hepatic stellate cells through exosomal SMO to trigger Hedgehog pathway.CategoriesFunction, ExpressionSourceGeneRif: 6608PubMedEurope PMCCell Death Dis 12:326-326 (2021)Mapped to4
A novel protein encoded by circular SMO RNA is essential for Hedgehog signaling activation and glioblastoma tumorigenicity.Wu X., Xiao S., Zhang M., Yang L., Zhong J., Li B., Li F., Xia X., Li X.[...], Zhang N.View abstractAnnotationA novel protein encoded by circular SMO RNA is essential for Hedgehog signaling activation and glioblastoma tumorigenicity.CategoryFunctionSourceGeneRif: 6608PubMedEurope PMCGenome Biol 22:33-33 (2021)Mapped to4
Silencing of long non‑coding RNA NEAT1 inhibits hepatocellular carcinoma progression by downregulating SMO by sponging microRNA‑503.Sun C., Xiao T., Xiao Y., Li Y.View abstractAnnotationSilencing of long noncoding RNA NEAT1 inhibits hepatocellular carcinoma progression by downregulating SMO by sponging microRNA503.CategoriesFunction, ExpressionSourceGeneRif: 6608PubMedEurope PMCMol Med Rep 23:168-168 (2021)Mapped to4
Targeting Hedgehog Pathway and DNA Methyltransferases in Uterine Leiomyosarcoma Cells.Garcia N., Al-Hendy A., Baracat E.C., Carvalho K.C., Yang Q.View abstractAnnotationTargeting Hedgehog Pathway and DNA Methyltransferases in Uterine Leiomyosarcoma Cells.CategoriesFunction, ExpressionSourceGeneRif: 6608PubMedEurope PMCCells 10:E53-E53 (2020)Mapped to8
sEVs from tonsil-derived mesenchymal stromal cells alleviate activation of hepatic stellate cells and liver fibrosis through miR-486-5p.Kim J., Lee C., Shin Y., Wang S., Han J., Kim M., Kim J.M., Shin S.C., Lee B.J.[...], Jung Y.View abstractAnnotationsEVs from tonsil-derived mesenchymal stromal cells alleviate activation of hepatic stellate cells and liver fibrosis through miR-486-5p.CategoriesFunction, ExpressionSourceGeneRif: 6608PubMedEurope PMCMol Ther 29:1471-1486 (2021)Mapped to4