Q99788 · CML1_HUMAN
- ProteinChemerin-like receptor 1
- GeneCMKLR1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids373 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2), TYRO3, MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis (PubMed:27716822).
Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism
Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism
(Microbial infection) Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
Enzyme and pathway databases
Protein family/group databases
Chemistry
Names & Taxonomy
Protein names
- Recommended nameChemerin-like receptor 1
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ99788
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Note: Internalizes efficiently in response to RARRES2.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-41 | Extracellular | ||||
Sequence: MRMEDEDYNTSISYGDEYPDYLDSIVVLEDLSPLEARVTRI | ||||||
Transmembrane | 42-64 | Helical; Name=1 | ||||
Sequence: FLVVVYSIVCFLGILGNGLVIII | ||||||
Topological domain | 65-75 | Cytoplasmic | ||||
Sequence: ATFKMKKTVNM | ||||||
Transmembrane | 76-97 | Helical; Name=2 | ||||
Sequence: VWFLNLAVADFLFNVFLPIHIT | ||||||
Topological domain | 98-114 | Extracellular | ||||
Sequence: YAAMDYHWVFGTAMCKI | ||||||
Transmembrane | 115-135 | Helical; Name=3 | ||||
Sequence: SNFLLIHNMFTSVFLLTIISS | ||||||
Topological domain | 136-154 | Cytoplasmic | ||||
Sequence: DRCISVLLPVWSQNHRSVR | ||||||
Transmembrane | 155-176 | Helical; Name=4 | ||||
Sequence: LAYMACMVIWVLAFFLSSPSLV | ||||||
Topological domain | 177-224 | Extracellular | ||||
Sequence: FRDTANLHGKISCFNNFSLSTPGSSSWPTHSQMDPVGYSRHMVVTVTR | ||||||
Transmembrane | 225-245 | Helical; Name=5 | ||||
Sequence: FLCGFLVPVLIITACYLTIVC | ||||||
Topological domain | 246-261 | Cytoplasmic | ||||
Sequence: KLQRNRLAKTKKPFKI | ||||||
Transmembrane | 262-282 | Helical; Name=6 | ||||
Sequence: IVTIIITFFLCWCPYHTLNLL | ||||||
Topological domain | 283-300 | Extracellular | ||||
Sequence: ELHHTAMPGSVFSLGLPL | ||||||
Transmembrane | 301-320 | Helical; Name=7 | ||||
Sequence: ATALAIANSCMNPILYVFMG | ||||||
Topological domain | 321-373 | Cytoplasmic | ||||
Sequence: QDFKKFKVALFSRLVNALSEDTGHSSYPSHRSFTKMSSMNERTSMNERETGML |
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 594 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond, modified residue, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000069307 | 1-373 | UniProt | Chemerin-like receptor 1 | |||
Sequence: MRMEDEDYNTSISYGDEYPDYLDSIVVLEDLSPLEARVTRIFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLSTPGSSSWPTHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKKFKVALFSRLVNALSEDTGHSSYPSHRSFTKMSSMNERTSMNERETGML | |||||||
Glycosylation | 9 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Disulfide bond | 112↔189 | UniProt | |||||
Sequence: CKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISC | |||||||
Glycosylation | 192 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Modified residue | 339 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 342 | UniProt | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 342 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue | 349 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 349 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 352 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 358 | UniProt | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant expression in monocyte-derived macrophage and immature dendritic cells (DCs). High expression in blood monocytes and low levels in polymorphonuclear cells and T-cells. Expressed on endothelial cells. Highly expressed in differentiating adipocytes.
Induction
Up-regulated by inflammatory cytokines TNF-alpha and IFN-gamma in monocytes. Up-regulated by TNF-alpha, IL-1-beta and IL-6 in endothelial cells.
Developmental stage
Expressed during bone development.
Gene expression databases
Organism-specific databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 341-373 | Disordered | ||||
Sequence: DTGHSSYPSHRSFTKMSSMNERTSMNERETGML |
Sequence similarities
Belongs to the chemokine-like receptor (CMKLR) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q99788-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameA
- NoteMay be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
- Length373
- Mass (Da)42,322
- Last updated2001-11-16 v2
- Checksum5244B9738EC93834
Q99788-2
- NameB
- Differences from canonical
- 1-2: Missing
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_001985 | 1-2 | in isoform B | |||
Sequence: Missing | ||||||
Sequence conflict | 248 | in Ref. 2; AAC51258 | ||||
Sequence: Q → H |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U79526 EMBL· GenBank· DDBJ | AAC51258.1 EMBL· GenBank· DDBJ | mRNA | ||
U79527 EMBL· GenBank· DDBJ | AAC51259.1 EMBL· GenBank· DDBJ | mRNA | ||
Y14838 EMBL· GenBank· DDBJ | CAA75112.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB065871 EMBL· GenBank· DDBJ | BAC06089.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY497547 EMBL· GenBank· DDBJ | AAR90850.1 EMBL· GenBank· DDBJ | mRNA | ||
AK291800 EMBL· GenBank· DDBJ | BAF84489.1 EMBL· GenBank· DDBJ | mRNA | ||
BT019556 EMBL· GenBank· DDBJ | AAV38363.1 EMBL· GenBank· DDBJ | mRNA | ||
BT019557 EMBL· GenBank· DDBJ | AAV38364.1 EMBL· GenBank· DDBJ | mRNA | ||
AC009729 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC063957 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471054 EMBL· GenBank· DDBJ | EAW97810.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471054 EMBL· GenBank· DDBJ | EAW97811.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC106927 EMBL· GenBank· DDBJ | AAI06928.1 EMBL· GenBank· DDBJ | mRNA | ||
BC106928 EMBL· GenBank· DDBJ | AAI06929.1 EMBL· GenBank· DDBJ | mRNA |