Q99788 · CML1_HUMAN

  • Protein
    Chemerin-like receptor 1
  • Gene
    CMKLR1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2), TYRO3, MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis (PubMed:27716822).
Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism
(Microbial infection) Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Cellular Componentplasma membrane
Molecular Functionadipokinetic hormone binding
Molecular Functionadipokinetic hormone receptor activity
Molecular Functionchemokine receptor activity
Molecular Functioncomplement receptor activity
Molecular FunctionG protein-coupled receptor activity
Molecular Functionsignaling receptor activity
Biological Processchemotaxis
Biological Processcomplement receptor mediated signaling pathway
Biological ProcessG protein-coupled receptor signaling pathway
Biological Processimmune response
Biological Processinflammatory response
Biological Processnegative regulation of interleukin-12 production
Biological Processnegative regulation of NF-kappaB transcription factor activity
Biological Processphospholipase C-activating G protein-coupled receptor signaling pathway
Biological Processpositive regulation of cold-induced thermogenesis
Biological Processpositive regulation of cytosolic calcium ion concentration
Biological Processpositive regulation of fat cell differentiation
Biological Processpositive regulation of macrophage chemotaxis
Biological Processregulation of calcium-mediated signaling
Biological Processskeletal system development

Keywords

Enzyme and pathway databases

Protein family/group databases

Chemistry

Names & Taxonomy

Protein names

  • Recommended name
    Chemerin-like receptor 1
  • Alternative names
    • Chemokine-like receptor 1
    • G-protein coupled receptor ChemR23
    • G-protein coupled receptor DEZ

Gene names

    • Name
      CMKLR1
    • Synonyms
      CHEMR23, DEZ

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q99788
  • Secondary accessions
    • A8K6Y5
    • O75748
    • Q3KP37
    • Q5U0H0
    • Q99789

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Note: Internalizes efficiently in response to RARRES2.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-41Extracellular
Transmembrane42-64Helical; Name=1
Topological domain65-75Cytoplasmic
Transmembrane76-97Helical; Name=2
Topological domain98-114Extracellular
Transmembrane115-135Helical; Name=3
Topological domain136-154Cytoplasmic
Transmembrane155-176Helical; Name=4
Topological domain177-224Extracellular
Transmembrane225-245Helical; Name=5
Topological domain246-261Cytoplasmic
Transmembrane262-282Helical; Name=6
Topological domain283-300Extracellular
Transmembrane301-320Helical; Name=7
Topological domain321-373Cytoplasmic

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 594 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond, modified residue, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00000693071-373UniProtChemerin-like receptor 1
Glycosylation9UniProtN-linked (GlcNAc...) asparagine
Disulfide bond112↔189UniProt
Glycosylation192UniProtN-linked (GlcNAc...) asparagine
Modified residue339UniProtPhosphoserine
Modified residue342UniProtPhosphothreonine
Modified residue (large scale data)342PRIDEPhosphothreonine
Modified residue349UniProtPhosphoserine
Modified residue (large scale data)349PRIDEPhosphoserine
Modified residue352UniProtPhosphoserine
Modified residue358UniProtPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant expression in monocyte-derived macrophage and immature dendritic cells (DCs). High expression in blood monocytes and low levels in polymorphonuclear cells and T-cells. Expressed on endothelial cells. Highly expressed in differentiating adipocytes.

Induction

Up-regulated by inflammatory cytokines TNF-alpha and IFN-gamma in monocytes. Up-regulated by TNF-alpha, IL-1-beta and IL-6 in endothelial cells.

Developmental stage

Expressed during bone development.

Gene expression databases

Organism-specific databases

Interaction

Protein-protein interaction databases

Chemistry

Miscellaneous

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region341-373Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q99788-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    A
  • Note
    May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    373
  • Mass (Da)
    42,322
  • Last updated
    2001-11-16 v2
  • Checksum
    5244B9738EC93834
MRMEDEDYNTSISYGDEYPDYLDSIVVLEDLSPLEARVTRIFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLSTPGSSSWPTHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKKFKVALFSRLVNALSEDTGHSSYPSHRSFTKMSSMNERTSMNERETGML

Q99788-2

  • Name
    B
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-2: Missing

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F8VYN7F8VYN7_HUMANCMKLR1147
F8VSC8F8VSC8_HUMANCMKLR1143

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0019851-2in isoform B
Sequence conflict248in Ref. 2; AAC51258

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U79526
EMBL· GenBank· DDBJ
AAC51258.1
EMBL· GenBank· DDBJ
mRNA
U79527
EMBL· GenBank· DDBJ
AAC51259.1
EMBL· GenBank· DDBJ
mRNA
Y14838
EMBL· GenBank· DDBJ
CAA75112.1
EMBL· GenBank· DDBJ
Genomic DNA
AB065871
EMBL· GenBank· DDBJ
BAC06089.1
EMBL· GenBank· DDBJ
Genomic DNA
AY497547
EMBL· GenBank· DDBJ
AAR90850.1
EMBL· GenBank· DDBJ
mRNA
AK291800
EMBL· GenBank· DDBJ
BAF84489.1
EMBL· GenBank· DDBJ
mRNA
BT019556
EMBL· GenBank· DDBJ
AAV38363.1
EMBL· GenBank· DDBJ
mRNA
BT019557
EMBL· GenBank· DDBJ
AAV38364.1
EMBL· GenBank· DDBJ
mRNA
AC009729
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC063957
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471054
EMBL· GenBank· DDBJ
EAW97810.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471054
EMBL· GenBank· DDBJ
EAW97811.1
EMBL· GenBank· DDBJ
Genomic DNA
BC106927
EMBL· GenBank· DDBJ
AAI06928.1
EMBL· GenBank· DDBJ
mRNA
BC106928
EMBL· GenBank· DDBJ
AAI06929.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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