Q99731 · CCL19_HUMAN

  • Protein
    C-C motif chemokine 19
  • Gene
    CCL19
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Cellular Componentextracellular space
Molecular FunctionCCR chemokine receptor binding
Molecular FunctionCCR10 chemokine receptor binding
Molecular FunctionCCR7 chemokine receptor binding
Molecular Functionchemokine activity
Molecular Functionchemokine receptor binding
Biological Processantimicrobial humoral immune response mediated by antimicrobial peptide
Biological Processcell chemotaxis
Biological Processcell communication
Biological Processcell maturation
Biological Processcellular response to virus
Biological Processchemokine-mediated signaling pathway
Biological Processdendritic cell chemotaxis
Biological Processestablishment of T cell polarity
Biological Processimmune response
Biological Processimmunological synapse formation
Biological Processinflammatory response
Biological Processintracellular calcium ion homeostasis
Biological Processmature conventional dendritic cell differentiation
Biological Processmyeloid dendritic cell chemotaxis
Biological Processnegative regulation of dendritic cell apoptotic process
Biological Processpositive regulation of canonical NF-kappaB signal transduction
Biological Processpositive regulation of cell migration
Biological Processpositive regulation of cell motility
Biological Processpositive regulation of chemotaxis
Biological Processpositive regulation of dendritic cell antigen processing and presentation
Biological Processpositive regulation of dendritic cell dendrite assembly
Biological Processpositive regulation of endocytosis
Biological Processpositive regulation of ERK1 and ERK2 cascade
Biological Processpositive regulation of glycoprotein biosynthetic process
Biological Processpositive regulation of GTPase activity
Biological Processpositive regulation of interleukin-1 beta production
Biological Processpositive regulation of interleukin-12 production
Biological Processpositive regulation of JNK cascade
Biological Processpositive regulation of JUN kinase activity
Biological Processpositive regulation of neutrophil chemotaxis
Biological Processpositive regulation of non-canonical NF-kappaB signal transduction
Biological Processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Processpositive regulation of protein kinase activity
Biological Processpositive regulation of receptor-mediated endocytosis
Biological Processpositive regulation of T cell proliferation
Biological Processpositive regulation of T-helper 1 cell differentiation
Biological Processpositive regulation of tumor necrosis factor production
Biological Processregulation of cell projection assembly
Biological Processrelease of sequestered calcium ion into cytosol
Biological Processresponse to nitric oxide
Biological Processresponse to prostaglandin E
Biological Processresponse to virus
Biological ProcessT cell costimulation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    C-C motif chemokine 19
  • Alternative names
    • Beta-chemokine exodus-3
    • CK beta-11
    • Epstein-Barr virus-induced molecule 1 ligand chemokine (EBI1 ligand chemokine; ELC)
    • Macrophage inflammatory protein 3 beta (MIP-3-beta)
    • Small-inducible cytokine A19

Gene names

    • Name
      CCL19
    • Synonyms
      ELC, MIP3B, SCYA19

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q99731
  • Secondary accessions
    • O00697
    • O00736

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Variants

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The viewer provides 79 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_000000521422-98C-C motif chemokine 19
Disulfide bond29↔55
Disulfide bond30↔71

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed at high levels in the lymph nodes, thymus and appendix. Intermediate levels seen in colon and trachea, while low levels found in spleen, small intestine, lung, kidney and stomach.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Interacts with TNFAIP6 (via Link domain).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q99731MEOX2 Q6FHY53EBI-11711434, EBI-16439278
BINARY PRO_0000005214TNFAIP6 P980662EBI-11711510, EBI-11700693

Protein-protein interaction databases

Miscellaneous

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    98
  • Mass (Da)
    10,993
  • Last updated
    1997-05-01 v1
  • Checksum
    0D2516DB2EB1C81B
MALLLALSLLVLWTSPAPTLSGTNDAEDCCLSVTQKPIPGYIVRNFHYLLIKDGCRVPAVVFTTLRGRQLCAPPDQPWVERIIQRLQRTSAKMKRRSS

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
Q5VZ75Q5VZ75_HUMANCCL19104

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U77180
EMBL· GenBank· DDBJ
AAC50944.1
EMBL· GenBank· DDBJ
mRNA
AB000887
EMBL· GenBank· DDBJ
BAA20383.1
EMBL· GenBank· DDBJ
mRNA
U88321
EMBL· GenBank· DDBJ
AAC23905.1
EMBL· GenBank· DDBJ
mRNA
AJ223410
EMBL· GenBank· DDBJ
CAA11307.1
EMBL· GenBank· DDBJ
Genomic DNA
BC027968
EMBL· GenBank· DDBJ
AAH27968.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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