Q98GN8 · CNGK1_RHILO

Function

function

Cyclic nucleotide-regulated potassium channel activated by cAMP.

Features

Showing features for binding site.

135550100150200250300350
TypeIDPosition(s)Description
Binding site297-2983',5'-cyclic AMP (UniProtKB | ChEBI)
Binding site307-3083',5'-cyclic AMP (UniProtKB | ChEBI)
Binding site3483',5'-cyclic AMP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular FunctioncAMP binding
Molecular Functionidentical protein binding
Molecular Functionpotassium channel activity
Molecular Functionprotein-containing complex binding

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Cyclic nucleotide-gated potassium channel mll3241
  • Alternative names
    • MlotiK1 channel

Gene names

    • Ordered locus names
      mll3241

Organism names

Accessions

  • Primary accession
    Q98GN8

Proteomes

Subcellular Location

Features

Showing features for topological domain, transmembrane, intramembrane.

TypeIDPosition(s)Description
Topological domain1-12Cytoplasmic
Transmembrane13-30Helical; Name=Segment S1
Topological domain31-38Periplasmic
Transmembrane39-61Helical; Name=Segment S2
Topological domain62-74Cytoplasmic
Transmembrane75-94Helical; Name=Segment S3
Transmembrane95-112Helical; Name=Segment S4
Topological domain113-129Cytoplasmic
Transmembrane130-150Helical; Name=Segment S5
Topological domain151-161Periplasmic
Intramembrane162-180Pore-forming
Topological domain181-185Periplasmic
Transmembrane186-210Helical; Name=Segment S6
Topological domain211-355Cytoplasmic

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis203Increased channel conductance.
Mutagenesis215Increased channel conductance.
Mutagenesis227Loss of channel activity.
Mutagenesis348Loss of cAMP binding. Loss of channel activity.

Chemistry

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003515011-355Cyclic nucleotide-gated potassium channel mll3241

Interaction

Subunit

Homotetramer.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q98GN8mll3241 Q98GN82EBI-15658025, EBI-15658025

Protein-protein interaction databases

Family & Domains

Features

Showing features for motif.

TypeIDPosition(s)Description
Motif175-180Selectivity filter

Sequence similarities

Belongs to the potassium channel family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    355
  • Mass (Da)
    37,735
  • Last updated
    2001-10-01 v1
  • Checksum
    35EE06373D563933
MSVLPFLRIYAPLNAVLAAPGLLAVAALTIPDMSGRSRLALAALLAVIWGAYLLQLAATLLKRRAGVVRDRTPKIAIDVLAVLVPLAAFLLDGSPDWSLYCAVWLLKPLRDSTFFPVLGRVLANEARNLIGVTTLFGVVLFAVALAAYVIERDIQPEKFGSIPQAMWWAVVTLSTTGYGDTIPQSFAGRVLAGAVMMSGIGIFGLWAGILATGFYQEVRRGDFVRNWQLVAAVPLFQKLGPAVLVEIVRALRARTVPAGAVICRIGEPGDRMFFVVEGSVSVATPNPVELGPGAFFGEMALISGEPRSATVSAATTVSLLSLHSADFQMLCSSSPEIAEIFRKTALERRGAAASA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BA000012
EMBL· GenBank· DDBJ
BAB50178.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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