Q98949 · TYRO3_CHICK

  • Protein
    Tyrosine-protein kinase receptor TYRO3
  • Gene
    TYRO3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, enhances PI3-kinase activity and activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes (By similarity).

Catalytic activity

Features

Showing features for binding site, active site.

1873100200300400500600700800
TypeIDPosition(s)Description
Binding site511-519ATP (UniProtKB | ChEBI)
Binding site537ATP (UniProtKB | ChEBI)
Active site642Proton acceptor

GO annotations

AspectTerm
Cellular Componentplasma membrane
Cellular Componentreceptor complex
Molecular FunctionATP binding
Molecular Functiontransmembrane receptor protein tyrosine kinase activity
Biological Processcell adhesion
Biological Processcell migration
Biological Processnervous system development
Biological Processphagocytosis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tyrosine-protein kinase receptor TYRO3
  • EC number
  • Alternative names
    • Retina-expressed kinase (Rek)

Gene names

    • Name
      TYRO3
    • Synonyms
      REK

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus

Accessions

  • Primary accession
    Q98949

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type I membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain29-416Extracellular
Transmembrane417-437Helical
Topological domain438-873Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond, modified residue.

TypeIDPosition(s)Description
Signal1-28
ChainPRO_000034611429-873Tyrosine-protein kinase receptor TYRO3
Glycosylation51N-linked (GlcNAc...) asparagine
Disulfide bond52↔105
Disulfide bond148↔191
Glycosylation179N-linked (GlcNAc...) asparagine
Glycosylation184N-linked (GlcNAc...) asparagine
Glycosylation218N-linked (GlcNAc...) asparagine
Glycosylation228N-linked (GlcNAc...) asparagine
Glycosylation281N-linked (GlcNAc...) asparagine
Glycosylation353N-linked (GlcNAc...) asparagine
Glycosylation367N-linked (GlcNAc...) asparagine
Modified residue673Phosphotyrosine; by autocatalysis

Post-translational modification

Autophosphorylated on tyrosine residues.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Detected in embryonic retina (at protein level). detected in brain, retina, kidney and in retinal Mueller glia-like cells.

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain29-116Ig-like C2-type 1
Domain127-208Ig-like C2-type 2
Domain215-308Fibronectin type-III 1
Domain310-403Fibronectin type-III 2
Domain505-776Protein kinase
Region845-873Disordered

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    873
  • Mass (Da)
    96,402
  • Last updated
    1997-02-01 v1
  • Checksum
    6294E173C5D8104E
MELRRSMALPRLLLLGLWAAALRDGAVAAGMKFTGSPIKLKVSQGQPVKLNCSLEGMEDPEMLWIKDGAVVQSVDQVYIPVDEDHWIGFLSLKSVERTDSGKYWCQVENGGKKEESQQVWLIVEGVPYFTVEPEDVSVSPNAPFHMACAAVGPPEPVTIVWWMGDSRVGLPDISPSILNVSGINQSTMFSCEAHNVKGLSSSRTATVQIKAMPLPPLNVTVSQVTSSNASVVWVPGFDGRAPLHSCTLQVAESPDGQEVSTEVAPVPPFAYGVQGLKHSTNYSVRVQCSNEMGSSPFTERVYFQTLELAPSSTPQNIHVIQRDPGLVLEWEGVAPDVLKENVLGYRLEWIQDNVTQGEMIVQDTKANLTTWNPLKDLIIRVCVLNSAGCGPWSDLFLLEAQEVMGGQRQPPYGTSWVPVALGILTALVTAVALALILLRKRRKETRFGHAFGSVVGRGDPAVHFRAARSFNREGPELIEATLESVGISDELKTKLKDVLIQEQQFTLGRMLGKGEFGSVREALLKLDDGSFQKVAVKMLKADIFTSTDIEEFLREAACMKEFDHPHVTKLIGVSLRSRPKGRLPIPMVILPFMKHGDLHAFLLMSRIGENPFNLPLQTLLKFMIDIASGMEYLSSKNFIHRDLAARNCMLDENMNVSVADFGLSKKIYSGDYYRQGCASKLPVKWLALESLADNLYTTHSDVWAFGVTMWEIVTRGQTPYAGIENAEIYNYLISGNRLKQPPECLEDVYDLMCRCWHPEPKLRPSFGVLRSQLEMIRGRMSTLSLSQDPLYVNIGKDKESSVSDPAVHTSFGNTDGDETIAGAAAAAITSDYRYIMSPLCLGDDVEGERHPEGQEGENKSLLYELETEGEKSC

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U70045
EMBL· GenBank· DDBJ
AAC60041.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp