Q98300 · A28_MCV1
- ProteinEnvelope protein A28 homolog
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids141 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Envelope protein required for virus entry into host cell and for cell-cell fusion (syncytium formation).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | viral envelope | |
Cellular Component | virion membrane | |
Biological Process | membrane fusion involved in viral entry into host cell | |
Biological Process | symbiont entry into host cell |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameEnvelope protein A28 homolog
- Alternative names
Gene names
Organism names
- Taxonomic lineageViruses > Varidnaviria > Bamfordvirae > Nucleocytoviricota > Pokkesviricetes > Chitovirales > Poxviridae > Chordopoxvirinae > Molluscipoxvirus > Molluscum contagiosum virus
- Virus hosts
Accessions
- Primary accessionQ98300
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Virion membrane ; Single-pass type II membrane protein
Note: Component of the intracellular mature virion (IMV) membrane.
Features
Showing features for transmembrane, topological domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 1-21 | Helical; Signal-anchor for type II membrane protein | ||||
Sequence: MDPLSVFFLVVAAAAVCTLLL | ||||||
Topological domain | 22-140 | Virion surface | ||||
Sequence: QAYAVYENFDSILEFNDAHASLEYSKSLGGSYIDKHVFDPNDGVADVTQKWRCALYGKVYVSASAFGFYAQPDGSKRTFSTRDDCVDFTFGTADTSRVVNPCTDPNGAQAEDCAFLKSV |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000099293 | 1-141 | Envelope protein A28 homolog | |||
Sequence: MDPLSVFFLVVAAAAVCTLLLQAYAVYENFDSILEFNDAHASLEYSKSLGGSYIDKHVFDPNDGVADVTQKWRCALYGKVYVSASAFGFYAQPDGSKRTFSTRDDCVDFTFGTADTSRVVNPCTDPNGAQAEDCAFLKSVL |
Post-translational modification
Contains two intramolecular disulfide bonds. They are created by the viral disulfide bond formation pathway, a poxvirus-specific pathway that operates on the cytoplasmic side of the MV membranes (By similarity).
Keywords
- PTM
Expression
Keywords
- Developmental stage
Family & Domains
Sequence similarities
Belongs to the poxviridae A28 protein family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length141
- Mass (Da)15,354
- Last updated1997-02-01 v1
- Checksum0BD4DD3A5A20FCEB
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U60315 EMBL· GenBank· DDBJ | AAC55262.1 EMBL· GenBank· DDBJ | Genomic DNA |