Q98234 · GPX_MCV1

Function

function

May protect the virus and component of infected cells from oxidative damage by peroxides whose formation may be stimulated by infection.

Miscellaneous

This enzyme has been acquitted by lateral transfer from its human host and has retained 74% identity with cellular GPX1.

Catalytic activity

Features

Showing features for active site, site.

122020406080100120140160180200220
TypeIDPosition(s)Description
Active site64
Site64Subject to oxidation and hydroselenide loss to dehydroalanine

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Molecular Functionglutathione peroxidase activity
Biological Processglutathione metabolic process
Biological Processhydrogen peroxide catabolic process
Biological Processresponse to hydrogen peroxide
Biological Processresponse to selenium ion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glutathione peroxidase
  • EC number
  • Short names
    GPx; GSHPx

Gene names

    • Name
      GPX1
    • Ordered locus names
      MC066L

Organism names

Accessions

  • Primary accession
    Q98234

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003187661-220Glutathione peroxidase

Post-translational modification

During periods of oxidative stress, Sec-64 may react with a superoxide radical, irreversibly lose hydroselenide and be converted to dehydroalanine.

Family & Domains

Sequence similarities

Belongs to the glutathione peroxidase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    220
  • Mass (Da)
    24,218
  • Last updated
    2008-02-26 v2
  • Checksum
    C51FC8C2BF704247
MADGSGARFPRFSELCAKYAAQLAAAETRSVYAFSARPITGGEPVSLGFLRGRVLLIENVASLUGSTVREYTQMNELQRRLGARGLVVLGFPCNQFGHQENAQNAEILPSLKHVRPGNGFEPNFMLFEKCEVNGARAHPLFAFLREALPAPSDDMSTLVSDPQLIAWSPVCRNDVAWNFEKFLVGADGTPVRRYSHRCQTLAVEPDIEALLPPPARGYYA

Features

Showing features for non-standard residue.

TypeIDPosition(s)Description
Non-standard residue64Selenocysteine

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U60315
EMBL· GenBank· DDBJ
AAC55194.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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