Q97UY8 · GLCV_SACS2

Function

function

Part of the ABC transporter complex GlcSTUV involved in glucose uptake (Probable). Responsible for energy coupling to the transport system (PubMed:12823973, PubMed:14607117).
In vitro, as a free subunit, exhibits a constitutive ATPase activity (PubMed:11807278).

Catalytic activity

Kinetics

KM SUBSTRATE pH TEMPERATURE[C] NOTES EVIDENCE
290 μMATP

pH Dependence

Optimum pH is 6.5 for ATPase activity.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site40-46ATP (UniProtKB | ChEBI)
Binding site89ATP (UniProtKB | ChEBI)
Binding site166ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular ComponentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
Molecular FunctionABC-type ferric iron transporter activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Glucose import ATP-binding protein GlcV
  • EC number

Gene names

    • Name
      glcV
    • Ordered locus names
      SSO2850

Organism names

Accessions

  • Primary accession
    Q97UY8

Proteomes

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis142Decrease in ATPase activity. Can form dimers.
Mutagenesis144Loss of ATPase activity. Cannot form dimers. Forms an active heterodimer; when associated with A-166.
Mutagenesis166Loss of ATPase activity. Can form dimers in the presence of ATP-Mg2+. Forms an active heterodimer; when associated with A-144.
Mutagenesis166Strong decrease in ATPase activity. Can form dimers in the presence of ATP alone, without Mg2+.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004476151-353Glucose import ATP-binding protein GlcV

Proteomic databases

Interaction

Subunit

The complex is composed of two ATP-binding proteins (GlcV), two transmembrane proteins (GlcT and GlcU) and a solute-binding protein (GlcS) (Probable). Forms transient head-to-tail homodimers in the presence of ATP-Mg2+ (PubMed:14607117).

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-241ABC transporter

Domain

Consists of a typical ABC-ATPase domain, comprising two subdomains, connected by a linker region to a C-terminal domain of unknown function.

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    353
  • Mass (Da)
    39,113
  • Last updated
    2001-10-01 v1
  • Checksum
    772D42F471DCD980
MVRIIVKNVSKVFKKGKVVALDNVNINIENGERFGILGPSGAGKTTFMRIIAGLDVPSTGELYFDDRLVASNGKLIVPPEDRKIGMVFQTWALYPNLTAFENIAFPLTNMKMSKEEIRKRVEEVAKILDIHHVLNHFPRELSGGQQQRVALARALVKDPSLLLLDEPFSNLDARMRDSARALVKEVQSRLGVTLLVVSHDPADIFAIADRVGVLVKGKLVQVGKPEDLYDNPVSIQVASLIGEINELEGKVTNEGVVIGSLRFPVSVSSDRAIIGIRPEDVKLSKDVIKDDSWILVGKGKVKVIGYQGGLFRITITPLDSEEEIFTYSDHPIHSGEEVLVYVRKDKIKVFEKN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE006641
EMBL· GenBank· DDBJ
AAK42960.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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