Q96V54 · CREB_EMENI
- ProteinUbiquitin carboxyl-terminal hydrolase creB
- GenecreB
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids766 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Also plays a role in response to carbon starvation and the control of extracellular proteases activity.
Catalytic activity
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 64 | Nucleophile | |||
Active site | 417 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Molecular Function | cysteine-type deubiquitinase activity | |
Biological Process | carbon catabolite repression of transcription | |
Biological Process | protein deubiquitination | |
Biological Process | ubiquitin-dependent protein catabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUbiquitin carboxyl-terminal hydrolase creB
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Nidulantes
Accessions
- Primary accessionQ96V54
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000395684 | 1-766 | Ubiquitin carboxyl-terminal hydrolase creB | ||
Interaction
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias, coiled coil.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-32 | Disordered | |||
Domain | 55-466 | USP | |||
Region | 115-145 | Disordered | |||
Region | 243-267 | Disordered | |||
Compositional bias | 247-267 | Polar residues | |||
Region | 526-752 | Disordered | |||
Compositional bias | 532-547 | Polar residues | |||
Compositional bias | 548-571 | Pro residues | |||
Coiled coil | 573-620 | ||||
Compositional bias | 578-646 | Basic and acidic residues | |||
Compositional bias | 660-690 | Polar residues | |||
Compositional bias | 736-751 | Basic and acidic residues | |||
Sequence similarities
Belongs to the peptidase C19 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length766
- Mass (Da)86,229
- Last updated2001-12-01 v1
- ChecksumA29EC2B530092896
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 247-267 | Polar residues | |||
Compositional bias | 532-547 | Polar residues | |||
Compositional bias | 548-571 | Pro residues | |||
Compositional bias | 578-646 | Basic and acidic residues | |||
Compositional bias | 660-690 | Polar residues | |||
Compositional bias | 736-751 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF327414 EMBL· GenBank· DDBJ | AAL04454.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AACD01000061 EMBL· GenBank· DDBJ | EAA59795.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BN001302 EMBL· GenBank· DDBJ | CBF75829.1 EMBL· GenBank· DDBJ | Genomic DNA |