Q96V54 · CREB_EMENI

Function

function

Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Also plays a role in response to carbon starvation and the control of extracellular proteases activity.

Catalytic activity

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
    EC:3.4.19.12 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

1766100200300400500600700
TypeIDPosition(s)Description
Active site64Nucleophile
Active site417Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentnucleus
Molecular Functioncysteine-type deubiquitinase activity
Biological Processcarbon catabolite repression of transcription
Biological Processprotein deubiquitination
Biological Processubiquitin-dependent protein catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ubiquitin carboxyl-terminal hydrolase creB
  • EC number
  • Alternative names
    • Carbon catabolite repression protein B
    • Deubiquitinating enzyme creB
    • Ubiquitin thioesterase creB
    • Ubiquitin-hydrolyzing enzyme creB
    • Ubiquitin-specific-processing protease creB

Gene names

    • Name
      creB
    • Synonyms
      molB
    • ORF names
      AN3587

Organism names

Accessions

  • Primary accession
    Q96V54
  • Secondary accessions
    • C8V4E2
    • Q5B793

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003956841-766Ubiquitin carboxyl-terminal hydrolase creB

Interaction

Subunit

Interacts with creA, creC and qutD.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, domain, compositional bias, coiled coil.

Type
IDPosition(s)Description
Region1-32Disordered
Domain55-466USP
Region115-145Disordered
Region243-267Disordered
Compositional bias247-267Polar residues
Region526-752Disordered
Compositional bias532-547Polar residues
Compositional bias548-571Pro residues
Coiled coil573-620
Compositional bias578-646Basic and acidic residues
Compositional bias660-690Polar residues
Compositional bias736-751Basic and acidic residues

Sequence similarities

Belongs to the peptidase C19 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    766
  • Mass (Da)
    86,229
  • Last updated
    2001-12-01 v1
  • Checksum
    A29EC2B530092896
MGSFLKSFRKDVGSAAPSVGAPPAKKEPQPLPMTPLEKMLTELGPIRGDGSDKFYGMENFGNTCYCNSILQCLYYSVPFREAVLNYPKRTPIEDLEAALAKALRYQDPNARLEAEALAEKQKAANSPRPGQPPNPQQKPEDKDSPEYKKKLALQTLPLLETTDNSVSYGIPESLFSSLKDMFESIVGSQSRIGIIRPQHFLEVLRRENEMFRTAMHQDAHEFLNLLLNEVVVDVEKAAAKLLESPQPASDVSDSVIPSSSSGSRTPNTTRWVHELFEGLLTSETQCLTCEKASQRDEVFLDLSVDLEQHSSVTSCLRKFSAEEMLCERNKFHCDNCGGLQEAEKRMKIKRLPRILALHLKRFKYTEDLQRLQKLFHRVVYPYHLRLFNTTDDAEDPDRLYELYAVVVHIGGGPYHGHYVSIIKTQDRGWLLFDDEMVEPVDKNYVRNFFGDKPGLACAYVLFYQETTMEAVMKEQEQENTEPPVEVNASTLKQNGFSSSATLAHAHSASQVPTYEDHDRFTGLKRAPTAPQLSTHPEHTTTDSESLPSPAPDPAPLTSLPPIPPIPETPPAPLTSRKSDLQSKKERVKEEKERKAAEKEKEKQRRKEIETRLKDRQRREDDDLKAALEASKVSKEDEDRRNHAENGTSKKNAGGLGRFRSLSQRLSTKESRTSLSRIPPLPNGNHTLSKVPDESEQTHPKSPTPPAPLSRPASQPLNDDLLGSPRADTLAVPTEQEHIKNSKHDRSSHGKWRSFSLRKKSFNILSS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias247-267Polar residues
Compositional bias532-547Polar residues
Compositional bias548-571Pro residues
Compositional bias578-646Basic and acidic residues
Compositional bias660-690Polar residues
Compositional bias736-751Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF327414
EMBL· GenBank· DDBJ
AAL04454.1
EMBL· GenBank· DDBJ
Genomic DNA
AACD01000061
EMBL· GenBank· DDBJ
EAA59795.1
EMBL· GenBank· DDBJ
Genomic DNA
BN001302
EMBL· GenBank· DDBJ
CBF75829.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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