Q96SZ5 · AEDO_HUMAN

  • Protein
    2-aminoethanethiol dioxygenase
  • Gene
    ADO
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Plays a vital role in regulating thiol metabolism and preserving oxygen homeostasis by oxidizing the sulfur of cysteamine and N-terminal cysteine-containing proteins to their corresponding sulfinic acids using O2 as a cosubstrate (PubMed:17581819, PubMed:29752763, PubMed:31273118, PubMed:32601061).
Catalyzes the oxidation of cysteamine (2-aminoethanethiol) to hypotaurine (PubMed:17581819, PubMed:29752763, PubMed:32601061).
Catalyzes the oxidation of regulators of G-protein signaling 4 (RGS4) and 5 (RGS5) and interleukin-32 (IL32) (PubMed:31273118, PubMed:32601061).

Catalytic activity

Cofactor

Fe cation (UniProtKB | Rhea| CHEBI:24875 )

Kinetics

KM SUBSTRATE pH TEMPERATURE[C] NOTES EVIDENCE
3.4 mMcysteamine
123 μMRGS4
71.51 μMRGS5
33.6 μMIL32

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site112Fe cation (UniProtKB | ChEBI); catalytic
Binding site114Fe cation (UniProtKB | ChEBI); catalytic
Binding site193Fe cation (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncysteamine dioxygenase activity
Molecular Functioniron ion binding
Biological Processcellular response to hypoxia

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    2-aminoethanethiol dioxygenase
  • EC number
  • Alternative names
    • Cysteamine dioxygenase

Gene names

    • Name
      ADO
    • Synonyms
      C10orf22

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q96SZ5
  • Secondary accessions
    • B1AL29

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Features

Showing features for natural variant, mutagenesis.

TypeIDPosition(s)Description
Natural variantVAR_02533325in dbSNP:rs2236295
Natural variantVAR_02533439in dbSNP:rs10995311
Mutagenesis87Moderate reduction in enzyme activity.
Mutagenesis222Significant reduction in enzyme activity.
Mutagenesis223No significant reduction in enzyme activity.
Natural variantVAR_033691266in dbSNP:rs569705

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 321 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data), cross-link.

TypeIDPosition(s)SourceDescription
ChainPRO_00000897841-270UniProt2-aminoethanethiol dioxygenase
Modified residue (large scale data)186PRIDEPhosphothreonine
Cross-link220↔223UniProt3'-(S-cysteinyl)-tyrosine (Cys-Tyr)

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Monomer.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q96SZ5CAP2 P401233EBI-11102284, EBI-1051165
BINARY Q96SZ5DISC1 Q9NRI5-23EBI-11102284, EBI-11988027
BINARY Q96SZ5FAM76B Q5HYJ32EBI-11102284, EBI-751192

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region21-48Disordered
Region140-164Disordered

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    270
  • Mass (Da)
    29,751
  • Last updated
    2006-02-21 v2
  • Checksum
    6B496CCF16E92C9D
MPRDNMASLIQRIARQACLTFRGSGGGRGASDRDAASGPEAPMQPGFPENLSKLKSLLTQLRAEDLNIAPRKATLQPLPPNLPPVTYMHIYETDGFSLGVFLLKSGTSIPLHDHPGMHGMLKVLYGTVRISCMDKLDAGGGQRPRALPPEQQFEPPLQPREREAVRPGVLRSRAEYTEASGPCILTPHRDNLHQIDAVEGPAAFLDILAPPYDPDDGRDCHYYRVLEPVRPKEASSSACDLPREVWLLETPQADDFWCEGEPYPGPKVFP

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0AA34QVG9A0AA34QVG9_HUMANADO295

Sequence caution

The sequence BAB55123.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL133417
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471083
EMBL· GenBank· DDBJ
EAW54235.1
EMBL· GenBank· DDBJ
Genomic DNA
BC018660
EMBL· GenBank· DDBJ
AAH18660.3
EMBL· GenBank· DDBJ
mRNA
BC028589
EMBL· GenBank· DDBJ
AAH28589.2
EMBL· GenBank· DDBJ
mRNA
BC067740
EMBL· GenBank· DDBJ
AAH67740.2
EMBL· GenBank· DDBJ
mRNA
AK027453
EMBL· GenBank· DDBJ
BAB55123.1
EMBL· GenBank· DDBJ
mRNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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