Q96SY0 · INT14_HUMAN
- ProteinIntegrator complex subunit 14
- GeneINTS14
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids518 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | integrator complex | |
Cellular Component | nucleoplasm | |
Cellular Component | nucleus | |
Biological Process | regulation of transcription elongation by RNA polymerase II | |
Biological Process | snRNA 3'-end processing | |
Biological Process | snRNA processing |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameIntegrator complex subunit 14
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ96SY0
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 537 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000296266 | 1-518 | Integrator complex subunit 14 | |||
Sequence: MPTVVVMDVSLSMTRPVSIEGSEEYQRKHLAAHGLTMLFEHMATNYKLEFTALVVFSSLWELMVPFTRDYNTLQEALSNMDDYDKTCLESALVGVCNIVQQEWGGAIPCQVVLVTDGCLGIGRGSLRHSLATQNQRSESNRFPLPFPFPSKLYIMCMANLEELQSTDSLECLERLIDLNNGEGQIFTIDGPLCLKNVQSMFGKLIDLAYTPFHAVLKCGHLTADVQVFPRPEPFVVDEEIDPIPKVINTDLEIVGFIDIADISSPPVLSRHLVLPIALNKEGDEVGTGITDDNEDENSANQIAGKIPNFCVLLHGSLKVEGMVAIVQLGPEWHGMLYSQADSKKKSNLMMSLFEPGPEPLPWLGKMAQLGPISDAKENPYGEDDNKSPFPLQPKNKRSYAQNVTVWIKPSGLQTDVQKILRNARKLPEKTQTFYKELNRLRKAALAFGFLDLLKGVADMLERECTLLPETAHPDAAFQLTHAAQQLKLASTGTSEYAAYDQNITPLHTDFSGSSTERI | ||||||
Modified residue | 418 | N6-acetyllysine | ||||
Sequence: K |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Strongly expressed in numerous cancer cells compared with their non-cancerous counterparts (lung, prostate, colon, stomach and skin).
Gene expression databases
Organism-specific databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q96SY0 | INTS10 Q9NVR2 | 13 | EBI-4409724, EBI-536703 | |
BINARY | Q96SY0 | INTS13 Q9NVM9 | 16 | EBI-4409724, EBI-741429 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 2-204 | VWFA | ||||
Sequence: PTVVVMDVSLSMTRPVSIEGSEEYQRKHLAAHGLTMLFEHMATNYKLEFTALVVFSSLWELMVPFTRDYNTLQEALSNMDDYDKTCLESALVGVCNIVQQEWGGAIPCQVVLVTDGCLGIGRGSLRHSLATQNQRSESNRFPLPFPFPSKLYIMCMANLEELQSTDSLECLERLIDLNNGEGQIFTIDGPLCLKNVQSMFGKL |
Sequence similarities
Belongs to the INTS14 family.
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 4 isoforms produced by Alternative splicing.
Q96SY0-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length518
- Mass (Da)57,471
- Last updated2007-07-24 v2
- Checksum5B05ED69BA6451BD
Q96SY0-2
- Name2
Q96SY0-4
- Name4
- Differences from canonical
- 1-79: Missing
Q96SY0-3
- Name3
- Differences from canonical
- 4-74: VVVMDVSLSMTRPVSIEGSEEYQRKHLAAHGLTMLFEHMATNYKLEFTALVVFSSLWELMVPFTRDYNTLQ → ESLCRRTVSGDGHG
Computationally mapped potential isoform sequences
There are 9 potential isoforms mapped to this entry
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_044250 | 1-79 | in isoform 4 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_043277 | 4-74 | in isoform 3 | |||
Sequence: VVVMDVSLSMTRPVSIEGSEEYQRKHLAAHGLTMLFEHMATNYKLEFTALVVFSSLWELMVPFTRDYNTLQ → ESLCRRTVSGDGHG | ||||||
Sequence conflict | 7 | in Ref. 4; AAH37823 | ||||
Sequence: M → I | ||||||
Alternative sequence | VSP_027180 | 75-86 | in isoform 2 | |||
Sequence: EALSNMDDYDKT → VQNVVSYCMYRA | ||||||
Alternative sequence | VSP_027181 | 87-518 | in isoform 2 | |||
Sequence: Missing | ||||||
Sequence conflict | 89 | in Ref. 1; CAB66597 | ||||
Sequence: E → G | ||||||
Sequence conflict | 177 | in Ref. 2; BAB55140 | ||||
Sequence: D → Y | ||||||
Sequence conflict | 206 | in Ref. 1; CAB66597 | ||||
Sequence: D → G |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL136662 EMBL· GenBank· DDBJ | CAB66597.1 EMBL· GenBank· DDBJ | mRNA | ||
AK301033 EMBL· GenBank· DDBJ | BAG62647.1 EMBL· GenBank· DDBJ | mRNA | ||
AK027475 EMBL· GenBank· DDBJ | BAB55140.1 EMBL· GenBank· DDBJ | mRNA | ||
AK293207 EMBL· GenBank· DDBJ | BAG56747.1 EMBL· GenBank· DDBJ | mRNA | ||
AC027220 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC037823 EMBL· GenBank· DDBJ | AAH37823.1 EMBL· GenBank· DDBJ | mRNA | ||
BC007991 EMBL· GenBank· DDBJ | AAH07991.1 EMBL· GenBank· DDBJ | mRNA |