Q96SY0 · INT14_HUMAN

  • Protein
    Integrator complex subunit 14
  • Gene
    INTS14
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentintegrator complex
Cellular Componentnucleoplasm
Cellular Componentnucleus
Biological Processregulation of transcription elongation by RNA polymerase II
Biological ProcesssnRNA 3'-end processing
Biological ProcesssnRNA processing

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Integrator complex subunit 14
  • Alternative names
    • von Willebrand factor A domain-containing protein 9

Gene names

    • Name
      INTS14
    • Synonyms
      C15orf44
      , VWA9

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q96SY0
  • Secondary accessions
    • B4DDI6
    • B4DVD5
    • Q49AH8
    • Q96HX5
    • Q9H0S5

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 537 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002962661-518Integrator complex subunit 14
Modified residue418N6-acetyllysine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Strongly expressed in numerous cancer cells compared with their non-cancerous counterparts (lung, prostate, colon, stomach and skin).

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q96SY0INTS10 Q9NVR213EBI-4409724, EBI-536703
BINARY Q96SY0INTS13 Q9NVM916EBI-4409724, EBI-741429

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-204VWFA

Sequence similarities

Belongs to the INTS14 family.

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (4)
  • Sequence status
    Complete

This entry describes 4 isoforms produced by Alternative splicing.

Q96SY0-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    518
  • Mass (Da)
    57,471
  • Last updated
    2007-07-24 v2
  • Checksum
    5B05ED69BA6451BD
MPTVVVMDVSLSMTRPVSIEGSEEYQRKHLAAHGLTMLFEHMATNYKLEFTALVVFSSLWELMVPFTRDYNTLQEALSNMDDYDKTCLESALVGVCNIVQQEWGGAIPCQVVLVTDGCLGIGRGSLRHSLATQNQRSESNRFPLPFPFPSKLYIMCMANLEELQSTDSLECLERLIDLNNGEGQIFTIDGPLCLKNVQSMFGKLIDLAYTPFHAVLKCGHLTADVQVFPRPEPFVVDEEIDPIPKVINTDLEIVGFIDIADISSPPVLSRHLVLPIALNKEGDEVGTGITDDNEDENSANQIAGKIPNFCVLLHGSLKVEGMVAIVQLGPEWHGMLYSQADSKKKSNLMMSLFEPGPEPLPWLGKMAQLGPISDAKENPYGEDDNKSPFPLQPKNKRSYAQNVTVWIKPSGLQTDVQKILRNARKLPEKTQTFYKELNRLRKAALAFGFLDLLKGVADMLERECTLLPETAHPDAAFQLTHAAQQLKLASTGTSEYAAYDQNITPLHTDFSGSSTERI

Q96SY0-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 75-86: EALSNMDDYDKT → VQNVVSYCMYRA
    • 87-518: Missing

Q96SY0-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q96SY0-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 4-74: VVVMDVSLSMTRPVSIEGSEEYQRKHLAAHGLTMLFEHMATNYKLEFTALVVFSSLWELMVPFTRDYNTLQ → ESLCRRTVSGDGHG

Computationally mapped potential isoform sequences

There are 9 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
H3BV25H3BV25_HUMANINTS1476
H3BT02H3BT02_HUMANINTS1439
B4DVT3B4DVT3_HUMANINTS14482
H3BRY6H3BRY6_HUMANINTS14468
H3BP17H3BP17_HUMANINTS14154
H3BNR6H3BNR6_HUMANINTS1457
H3BN95H3BN95_HUMANINTS1471
H3BMK7H3BMK7_HUMANINTS14137
B4DJL6B4DJL6_HUMANINTS14554

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0442501-79in isoform 4
Alternative sequenceVSP_0432774-74in isoform 3
Sequence conflict7in Ref. 4; AAH37823
Alternative sequenceVSP_02718075-86in isoform 2
Alternative sequenceVSP_02718187-518in isoform 2
Sequence conflict89in Ref. 1; CAB66597
Sequence conflict177in Ref. 2; BAB55140
Sequence conflict206in Ref. 1; CAB66597

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL136662
EMBL· GenBank· DDBJ
CAB66597.1
EMBL· GenBank· DDBJ
mRNA
AK301033
EMBL· GenBank· DDBJ
BAG62647.1
EMBL· GenBank· DDBJ
mRNA
AK027475
EMBL· GenBank· DDBJ
BAB55140.1
EMBL· GenBank· DDBJ
mRNA
AK293207
EMBL· GenBank· DDBJ
BAG56747.1
EMBL· GenBank· DDBJ
mRNA
AC027220
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC037823
EMBL· GenBank· DDBJ
AAH37823.1
EMBL· GenBank· DDBJ
mRNA
BC007991
EMBL· GenBank· DDBJ
AAH07991.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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