Q96SB4 · SRPK1_HUMAN
- ProteinSRSF protein kinase 1
- GeneSRPK1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids655 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Cofactor
Activity regulation
Features
Showing features for binding site, active site.
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameSRSF protein kinase 1
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ96SB4
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Isoform 2
Isoform 1
Keywords
- Cellular component
Disease & Variants
Features
Showing features for mutagenesis, natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 37 | No effect on protein phosphorylation. | ||||
Sequence: S → A | ||||||
Mutagenesis | 51 | Protein phosphorylation impaired at this position. | ||||
Sequence: S → A | ||||||
Natural variant | VAR_051669 | 72 | in dbSNP:rs35519113 | |||
Sequence: I → T | ||||||
Mutagenesis | 222 | No effect on protein phosphorylation. | ||||
Sequence: S → A | ||||||
Mutagenesis | 311 | No effect on protein phosphorylation. | ||||
Sequence: S → G | ||||||
Mutagenesis | 436 | No effect on protein phosphorylation. | ||||
Sequence: S → G | ||||||
Mutagenesis | 555 | Protein phosphorylation impaired at this position. | ||||
Sequence: S → A | ||||||
Mutagenesis | 619 | No effect on protein phosphorylation. | ||||
Sequence: S → A |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 592 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000086674 | 1-655 | UniProt | SRSF protein kinase 1 | |||
Sequence: MERKVLALQARKKRTKAKKDKAQRKSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQKRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQTLMERDTEGGAAEINCNGVIEVINYTQNSNNETLRHKEDLHNANDCDVQNLNQESSFLSSQNGDSSTSQETDSCTPITSEVSDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPCEDEQEQEHNGPLDNKGKSTAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWLNS | |||||||
Modified residue | 51 | UniProt | Phosphoserine; by CK2 | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 51 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 309 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 309 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 311 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 311 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 333 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 333 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 514 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue | 555 | UniProt | Phosphoserine; by CK2 | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Gene expression databases
Organism-specific databases
Interaction
Subunit
Binary interactions
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-57 | Disordered | ||||
Sequence: MERKVLALQARKKRTKAKKDKAQRKSETQHRGSAPHSESDLPEQEEEILGSDDDEQE | ||||||
Compositional bias | 21-43 | Basic and acidic residues | ||||
Sequence: KAQRKSETQHRGSAPHSESDLPE | ||||||
Domain | 80-653 | Protein kinase | ||||
Sequence: YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQKRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQTLMERDTEGGAAEINCNGVIEVINYTQNSNNETLRHKEDLHNANDCDVQNLNQESSFLSSQNGDSSTSQETDSCTPITSEVSDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPCEDEQEQEHNGPLDNKGKSTAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWL | ||||||
Region | 238-341 | Disordered | ||||
Sequence: WQRSGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQKRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQT | ||||||
Compositional bias | 276-326 | Basic and acidic residues | ||||
Sequence: KRQAELLEKRMQEIEEMEKESGPGQKRPNKQEESESPVERPLKENPPNKMT | ||||||
Compositional bias | 327-341 | Polar residues | ||||
Sequence: QEKLEESSTIGQDQT | ||||||
Region | 397-417 | Disordered | ||||
Sequence: FLSSQNGDSSTSQETDSCTPI |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q96SB4-2
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name2
- Length655
- Mass (Da)74,325
- Last updated2008-10-14 v2
- Checksum900E980FE1C16B9A
Q96SB4-3
- Name1
- Synonyms1a
- NoteDue to intron retention.
- Differences from canonical
- 4-4: K → KGERWSGLRHEGQWSPGRGPGQRRELRLTAAVRFPDVRRPSTEVAPPHTPCLWAAGPRPSFRASSGAGRSRPLFPARPARALGPLQGPALGGRRRPPPARPLTRPETPPAHPARALLCAPWAASPTPAASPSPQPPPRQAPQPGLAPLLGLHPHLGRLLSSTFALHPSLSPA
Q96SB4-4
- Name3
- Differences from canonical
- 1-25: MERKVLALQARKKRTKAKKDKAQRK → MGIFVSFLR
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Features
Showing features for alternative sequence, compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_057356 | 1-25 | in isoform 3 | |||
Sequence: MERKVLALQARKKRTKAKKDKAQRK → MGIFVSFLR | ||||||
Alternative sequence | VSP_042130 | 4 | in isoform 1 | |||
Sequence: K → KGERWSGLRHEGQWSPGRGPGQRRELRLTAAVRFPDVRRPSTEVAPPHTPCLWAAGPRPSFRASSGAGRSRPLFPARPARALGPLQGPALGGRRRPPPARPLTRPETPPAHPARALLCAPWAASPTPAASPSPQPPPRQAPQPGLAPLLGLHPHLGRLLSSTFALHPSLSPA | ||||||
Compositional bias | 21-43 | Basic and acidic residues | ||||
Sequence: KAQRKSETQHRGSAPHSESDLPE | ||||||
Sequence conflict | 210 | in Ref. 6; AAH38292 | ||||
Sequence: I → T | ||||||
Compositional bias | 276-326 | Basic and acidic residues | ||||
Sequence: KRQAELLEKRMQEIEEMEKESGPGQKRPNKQEESESPVERPLKENPPNKMT | ||||||
Compositional bias | 327-341 | Polar residues | ||||
Sequence: QEKLEESSTIGQDQT | ||||||
Sequence conflict | 360 | in Ref. 7; AA sequence | ||||
Sequence: I → L | ||||||
Sequence conflict | 363 | in Ref. 7; AA sequence | ||||
Sequence: I → L | ||||||
Sequence conflict | 400-401 | in Ref. 1; AAA20530 | ||||
Sequence: SQ → LP |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U09564 EMBL· GenBank· DDBJ | AAA20530.1 EMBL· GenBank· DDBJ | mRNA | ||
AJ318054 EMBL· GenBank· DDBJ | CAC39299.1 EMBL· GenBank· DDBJ | mRNA | ||
AK299591 EMBL· GenBank· DDBJ | BAG61523.1 EMBL· GenBank· DDBJ | mRNA | ||
Z99128 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471081 EMBL· GenBank· DDBJ | EAX03859.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC038292 EMBL· GenBank· DDBJ | AAH38292.1 EMBL· GenBank· DDBJ | mRNA |