Q96R67 · OR4CC_HUMAN
- ProteinOlfactory receptor 4C12
- GeneOR4C12
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids309 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Odorant receptor.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | G protein-coupled receptor activity | |
Molecular Function | olfactory receptor activity |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOlfactory receptor 4C12
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ96R67
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-23 | Extracellular | ||||
Sequence: MEKKKNVTEFILIGLTQNPIMEK | ||||||
Transmembrane | 24-47 | Helical; Name=1 | ||||
Sequence: VTFVVFLVLYMITLSGNLLIVVTI | ||||||
Topological domain | 48-55 | Cytoplasmic | ||||
Sequence: TTSQALSS | ||||||
Transmembrane | 56-77 | Helical; Name=2 | ||||
Sequence: PMYFFLTHLSLIDTVYSSSSAP | ||||||
Topological domain | 78-98 | Extracellular | ||||
Sequence: KLIVDSFQEKKIISFNGCMAQ | ||||||
Transmembrane | 99-118 | Helical; Name=3 | ||||
Sequence: AYAEHIFGATEIILLTVMAC | ||||||
Topological domain | 119-137 | Cytoplasmic | ||||
Sequence: DCYVAICKPLNYTTIMSHS | ||||||
Transmembrane | 138-156 | Helical; Name=4 | ||||
Sequence: LCILLVAVAWVGGFLHATI | ||||||
Topological domain | 157-193 | Extracellular | ||||
Sequence: QILFTVWLPFCGPNVIGHFMCDLYPLLKLVCIDTHTL | ||||||
Transmembrane | 194-217 | Helical; Name=5 | ||||
Sequence: GLFVAVNSGFICLLNFLILVVSYV | ||||||
Topological domain | 218-233 | Cytoplasmic | ||||
Sequence: IILRSLKNNSLEGRCK | ||||||
Transmembrane | 234-256 | Helical; Name=6 | ||||
Sequence: ALSTCISHIIVVVLFFVPCIFVY | ||||||
Topological domain | 257-267 | Extracellular | ||||
Sequence: LRSVTTLPIDK | ||||||
Transmembrane | 268-287 | Helical; Name=7 | ||||
Sequence: AVAVFYTMVVPMLNPVVYTL | ||||||
Topological domain | 288-309 | Cytoplasmic | ||||
Sequence: RNAEVKSAIRKLWRKKVTSDND |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_034192 | 283 | in dbSNP:rs4598671 | |||
Sequence: V → L |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 762 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000150533 | 1-309 | Olfactory receptor 4C12 | |||
Sequence: MEKKKNVTEFILIGLTQNPIMEKVTFVVFLVLYMITLSGNLLIVVTITTSQALSSPMYFFLTHLSLIDTVYSSSSAPKLIVDSFQEKKIISFNGCMAQAYAEHIFGATEIILLTVMACDCYVAICKPLNYTTIMSHSLCILLVAVAWVGGFLHATIQILFTVWLPFCGPNVIGHFMCDLYPLLKLVCIDTHTLGLFVAVNSGFICLLNFLILVVSYVIILRSLKNNSLEGRCKALSTCISHIIVVVLFFVPCIFVYLRSVTTLPIDKAVAVFYTMVVPMLNPVVYTLRNAEVKSAIRKLWRKKVTSDND | ||||||
Glycosylation | 6 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 95↔187 | |||||
Sequence: CMAQAYAEHIFGATEIILLTVMACDCYVAICKPLNYTTIMSHSLCILLVAVAWVGGFLHATIQILFTVWLPFCGPNVIGHFMCDLYPLLKLVC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Organism-specific databases
Structure
Sequence
- Sequence statusComplete
- Length309
- Mass (Da)34,491
- Last updated2003-10-10 v2
- Checksum3C6AD9FA309457C9
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC136850 EMBL· GenBank· DDBJ | AAI36851.1 EMBL· GenBank· DDBJ | mRNA | ||
BC136851 EMBL· GenBank· DDBJ | AAI36852.1 EMBL· GenBank· DDBJ | mRNA | ||
AF399576 EMBL· GenBank· DDBJ | AAK95061.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK004413 EMBL· GenBank· DDBJ | DAA04811.1 EMBL· GenBank· DDBJ | Genomic DNA |