Q96QS6 · PSKH2_HUMAN
- ProteinSerine/threonine-protein kinase H2
- GenePSKH2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids385 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | protein serine kinase activity | |
Molecular Function | protein serine/threonine kinase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine/threonine-protein kinase H2
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ96QS6
- Secondary accessions
Proteomes
Organism-specific databases
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_040615 | 72 | in dbSNP:rs56407605 | |||
Sequence: G → D | ||||||
Natural variant | VAR_040616 | 79 | in dbSNP:rs35315725 | |||
Sequence: R → K | ||||||
Natural variant | VAR_040617 | 114 | in dbSNP:rs35915498 | |||
Sequence: R → Q | ||||||
Natural variant | VAR_040618 | 116 | in a lung adenocarcinoma sample; somatic mutation | |||
Sequence: S → I | ||||||
Natural variant | VAR_040619 | 132 | in dbSNP:rs16879427 | |||
Sequence: Q → R | ||||||
Natural variant | VAR_040620 | 148 | in dbSNP:rs56356246 | |||
Sequence: R → Q | ||||||
Natural variant | VAR_040621 | 176 | in dbSNP:rs6998760 | |||
Sequence: A → S | ||||||
Natural variant | VAR_040622 | 211 | in dbSNP:rs36074412 | |||
Sequence: G → R | ||||||
Natural variant | VAR_040623 | 212 | in a lung adenocarcinoma sample; somatic mutation; dbSNP:rs778066815 | |||
Sequence: K → I | ||||||
Natural variant | VAR_040624 | 225 | in dbSNP:rs34457516 | |||
Sequence: T → A | ||||||
Natural variant | VAR_040625 | 266 | in dbSNP:rs34037815 | |||
Sequence: S → R | ||||||
Natural variant | VAR_040626 | 336 | in dbSNP:rs16876805 | |||
Sequence: I → V |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 528 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000086171 | 1-385 | Serine/threonine-protein kinase H2 | |||
Sequence: MGCGASRKVVPGPPALAWAKHEGQNQAGVGGAGPGPEAAAQAAQRIQVARFRAKFDPRVLARYDIKALIGTGSFSRVVRVEQKTTKKPFAIKVMETREREGREACVSELSVLRRVSHRYIVQLMEIFETEDQVYMVMELATGGELFDRLIAQGSFTERDAVRILQMVADGIRYLHALQITHRNLKPENLLYYHPGEESKILITDFGLAYSGKKSGDWTMKTLCGTPEYIAPEVLLRKPYTSAVDMWALGVITYALLSGFLPFDDESQTRLYRKILKGKYNYTGEPWPSISHLAKDFIDKLLILEAGHRMSAGQALDHPWVITMAAGSSMKNLQRAISRNLMQRASPHSQSPGSAQSSKSHYSHKSRHMWSKRNLRIVESPLSALL |
Proteomic databases
PTM databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q96QS6 | CDC37 Q16543 | 4 | EBI-6424813, EBI-295634 | |
BINARY | Q96QS6 | HSP90AA1 P07900 | 3 | EBI-6424813, EBI-296047 | |
BINARY | Q96QS6 | HSP90AB1 P08238 | 4 | EBI-6424813, EBI-352572 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 63-320 | Protein kinase | ||||
Sequence: YDIKALIGTGSFSRVVRVEQKTTKKPFAIKVMETREREGREACVSELSVLRRVSHRYIVQLMEIFETEDQVYMVMELATGGELFDRLIAQGSFTERDAVRILQMVADGIRYLHALQITHRNLKPENLLYYHPGEESKILITDFGLAYSGKKSGDWTMKTLCGTPEYIAPEVLLRKPYTSAVDMWALGVITYALLSGFLPFDDESQTRLYRKILKGKYNYTGEPWPSISHLAKDFIDKLLILEAGHRMSAGQALDHPWV | ||||||
Compositional bias | 342-359 | Polar residues | ||||
Sequence: QRASPHSQSPGSAQSSKS | ||||||
Region | 342-367 | Disordered | ||||
Sequence: QRASPHSQSPGSAQSSKSHYSHKSRH |
Sequence similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length385
- Mass (Da)43,027
- Last updated2001-12-01 v1
- Checksum6472D63BC7688334
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 342-359 | Polar residues | ||||
Sequence: QRASPHSQSPGSAQSSKS |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY037806 EMBL· GenBank· DDBJ | AAK59985.1 EMBL· GenBank· DDBJ | mRNA | ||
BC126180 EMBL· GenBank· DDBJ | AAI26181.1 EMBL· GenBank· DDBJ | mRNA | ||
BC126182 EMBL· GenBank· DDBJ | AAI26183.1 EMBL· GenBank· DDBJ | mRNA |