Q96PU9 · CMA1A_HUMAN

  • Protein
    Ciliary microtubule associated protein 1A
  • Gene
    CIMAP1A
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Outer dense fibers are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail. May help to maintain the passive elastic structures and elastic recoil of the sperm tail.

Miscellaneous

'Shippo' is a Japanese word for tail.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytoskeleton
Cellular Componentouter dense fiber
Biological Processcell differentiation
Biological Processspermatogenesis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ciliary microtubule associated protein 1A
  • Alternative names
    • Outer dense fiber of sperm tails protein 3
    • Outer dense fiber protein 3
    • Sperm tail protein SHIPPO 1
    • Transcript induced in spermiogenesis protein 50

Gene names

    • Name
      CIMAP1A
    • Synonyms
      ODF3, SHIPPO1
      , TISP50

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q96PU9
  • Secondary accessions
    • B7ZLT0
    • Q69YX0

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Note: Expressed in the cytoplasmic lobe of spermatids.

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 309 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002994641-254Ciliary microtubule associated protein 1A

Proteomic databases

PTM databases

Expression

Tissue specificity

Testis-specific.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Microtubule inner protein component of sperm flagellar doublet microtubules.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q96PU9DYNLL1 P631673EBI-12002088, EBI-349105
BINARY Q96PU9HOGA1 Q86XE53EBI-12002088, EBI-9658477

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for repeat, region.

TypeIDPosition(s)Description
Repeat180-205STPGR 1
Region207-226Disordered
Repeat216-241STPGR 2

Sequence similarities

Belongs to the CIMAP family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

Q96PU9-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    254
  • Mass (Da)
    27,710
  • Last updated
    2001-12-01 v1
  • Checksum
    549AA2DEA35201E5
MTEEVWMGTWRPHRPRGPIMALYSSPGPKYLIPPTTGFMKHTPTKLRAPAYSFRGAPMLLAENCSPGPRYNVNPKILRTGKDLGPAYSILGRYQTKTMLTPGPGDYFPEKSTKYVFDSAPSHSISARTKAFRVDSTPGPAAYMLPMVMGPNTVGKASQPSFSIKGRSKLGGFSDDLHKTPGPAAYRQTDVRVTKFKAPQYTMAARVEPPGDKTLKPGPGAHSPEKVTLTKPCAPVVTFGIKHSDYMTPLLVDVE

Q96PU9-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 104-138: GDYFPEKSTKYVFDSAPSHSISARTKAFRVDSTPG → ALKSAFPSWTPRDPTWSPPVLEPRGPTPRMLGSPP
    • 139-254: Missing

Q96PU9-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_027686104-138in isoform 2
Alternative sequenceVSP_027687139-254in isoform 2
Alternative sequenceVSP_054893178-224in isoform 3

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB067774
EMBL· GenBank· DDBJ
BAB70734.1
EMBL· GenBank· DDBJ
mRNA
AY713299
EMBL· GenBank· DDBJ
AAW83203.1
EMBL· GenBank· DDBJ
mRNA
AL133658
EMBL· GenBank· DDBJ
CAH10709.1
EMBL· GenBank· DDBJ
mRNA
AC069287
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC126222
EMBL· GenBank· DDBJ
AAI26223.1
EMBL· GenBank· DDBJ
mRNA
BC126248
EMBL· GenBank· DDBJ
AAI26249.1
EMBL· GenBank· DDBJ
mRNA
BC144022
EMBL· GenBank· DDBJ
AAI44023.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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