Q96PC2 · IP6K3_HUMAN
- ProteinInositol hexakisphosphate kinase 3
- GeneIP6K3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids410 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.
Catalytic activity
- 1D-myo-inositol hexakisphosphate + ATP = 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 211-219 | substrate | ||||
Sequence: PCVLDLKMG |
GO annotations
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameInositol hexakisphosphate kinase 3
- EC number
- Short namesInsP6 kinase 3
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ96PC2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant, mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_031590 | 60 | in dbSNP:rs34431226 | |||
Sequence: R → W | ||||||
Mutagenesis | 217 | Loss of activity. | ||||
Sequence: K → A | ||||||
Natural variant | VAR_031591 | 308 | in dbSNP:rs34573836 | |||
Sequence: A → V | ||||||
Natural variant | VAR_031592 | 312 | in dbSNP:rs4713668 | |||
Sequence: V → I | ||||||
Mutagenesis | 325 | Strongly reduces activity. | ||||
Sequence: S → A | ||||||
Natural variant | VAR_031593 | 378 | in dbSNP:rs34343647 | |||
Sequence: Y → S |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 563 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000066881 | 1-410 | Inositol hexakisphosphate kinase 3 | |||
Sequence: MVVQNSADAGDMRAGVQLEPFLHQVGGHMSVMKYDEHTVCKPLVSREQRFYESLPLAMKRFTPQYKGTVTVHLWKDSTGHLSLVANPVKESQEPFKVSTESAAVAIWQTLQQTTGSNGSDCTLAQWPHAQLARSPKESPAKALLRSEPHLNTPAFSLVEDTNGNQVERKSFNPWGLQCHQAHLTRLCSEYPENKRHRFLLLENVVSQYTHPCVLDLKMGTRQHGDDASEEKKARHMRKCAQSTSACLGVRICGMQVYQTDKKYFLCKDKYYGRKLSVEGFRQALYQFLHNGSHLRRELLEPILHQLRALLSVIRSQSSYRFYSSSLLVIYDGQEPPERAPGSPHPHEAPQAAHGSSPGGLTKVDIRMIDFAHTTYKGYWNEHTTYDGPDPGYIFGLENLIRILQDIQEGE |
Proteomic databases
PTM databases
Expression
Tissue specificity
Detected in brain.
Gene expression databases
Organism-specific databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q96PC2 | FHL5 Q5TD97 | 3 | EBI-10990676, EBI-750641 | |
BINARY | Q96PC2 | KRTAP10-8 P60410 | 3 | EBI-10990676, EBI-10171774 | |
BINARY | Q96PC2 | LNX1 Q8TBB1 | 3 | EBI-10990676, EBI-739832 | |
BINARY | Q96PC2 | MED4 Q9NPJ6 | 3 | EBI-10990676, EBI-394607 | |
BINARY | Q96PC2 | MEOX2 Q6FHY5 | 3 | EBI-10990676, EBI-16439278 | |
BINARY | Q96PC2 | NIF3L1 Q9GZT8 | 3 | EBI-10990676, EBI-740897 | |
BINARY | Q96PC2 | NOTO A8MTQ0 | 3 | EBI-10990676, EBI-17490746 | |
BINARY | Q96PC2 | POLR2E P19388 | 6 | EBI-10990676, EBI-395189 | |
BINARY | Q96PC2 | TRAF2 Q12933 | 3 | EBI-10990676, EBI-355744 | |
BINARY | Q96PC2 | TRAF3 Q13114 | 5 | EBI-10990676, EBI-357631 | |
BINARY | Q96PC2 | TRIM27 P14373 | 3 | EBI-10990676, EBI-719493 | |
BINARY | Q96PC2 | TRIP6 Q15654 | 3 | EBI-10990676, EBI-742327 | |
BINARY | Q96PC2 | ZNF655 Q8N720 | 3 | EBI-10990676, EBI-625509 | |
BINARY | Q96PC2 | ZRANB1 Q9UGI0 | 3 | EBI-10990676, EBI-527853 |
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 333-358 | Disordered | ||||
Sequence: QEPPERAPGSPHPHEAPQAAHGSSPG |
Sequence similarities
Belongs to the inositol phosphokinase (IPK) family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length410
- Mass (Da)46,417
- Last updated2007-04-03 v2
- ChecksumCA61C7D4FA70F7F3
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0U1RRE0 | A0A0U1RRE0_HUMAN | IP6K3 | 76 |
Sequence caution
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 56 | in Ref. 1; AAL17053 | ||||
Sequence: L → Q | ||||||
Sequence conflict | 304 | in Ref. 2; BAB71225 | ||||
Sequence: H → L |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF393812 EMBL· GenBank· DDBJ | AAL17053.1 EMBL· GenBank· DDBJ | mRNA | ||
AK056586 EMBL· GenBank· DDBJ | BAB71225.2 EMBL· GenBank· DDBJ | mRNA | Frameshift |