Q96M69 · LRGUK_HUMAN
- ProteinLeucine-rich repeat and guanylate kinase domain-containing protein
- GeneLRGUK
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids825 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | acrosomal vesicle | |
Cellular Component | cell projection | |
Cellular Component | cytosol | |
Cellular Component | manchette | |
Molecular Function | ATP binding | |
Molecular Function | guanylate kinase activity | |
Biological Process | axoneme assembly | |
Biological Process | cell differentiation | |
Biological Process | spermatogenesis |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLeucine-rich repeat and guanylate kinase domain-containing protein
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ96M69
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Localizes to the acrosome and acroplaxome in round spermatids. Localizes to the manchette during spermiogenesis. Also found in the basal body of elongating spermatids, and in primary cilia of somatic cells.
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_040063 | 302 | in dbSNP:rs17167553 | |||
Sequence: D → Y | ||||||
Natural variant | VAR_040064 | 661 | in dbSNP:rs35149449 | |||
Sequence: A → V |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,006 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000326408 | 1-825 | Leucine-rich repeat and guanylate kinase domain-containing protein | |||
Sequence: MATSERALLRTRAASLLRGLGRSRTGARSLQFRAEKERQPCWSFPMGQKTKGSSNIASSYLLQQLMHRYQELDSDGDEDQGEGEAGSEESSESEMLNLEEEFDGVLREEAVAKALHHLGRSGSGTEQVYLNLTLSGCNLIDVSILCGYVHLQKLDLSANKIEDLSCVSCMPYLLELNASQNNLTTFFNFKPPKNLKKADFSHNQISEICDLSAYHALTKLILDGNEIEEISGLEMCNNLIHLSLANNKITTINGLNKLPIKILCLSNNQIEMITGLEDLKALQNLDLSHNQISSLQGLENHDLLEVINLEDNKIAELREIEYIKNLPILRVLNLLENPIQEKSEYWFFVIFMLLRLTELDQKKIKVEEKVSAVNKYDPPPEVVAAQDHLTHVVNSVMQPQRIFDSTLPSLDAPYPMLILAGPEACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFISQDVFDEMVNMGKFILTFSYGNHKYGLNRDTVEGIARDGLASCIHMEIEGVRSLKYSYFEPRYILVVPMNKEKYEGYLRRKGLFSRAEIEFAVSRVDLYIKINQNFPGYFDEVINADDLDVAYQKLSQLIREYLGLTEEPAKSLATTADVKTSHLKPEAHPTKYISSNMGDFLHSTDRNYLIKFWAKLSAKKTPAERDSIHRQHEAARQALMGRIRPDHTLLFQRGPVPAPLTSGLHYYTTLEELWKSFDLCEDYFKPPFGPYPEKSGKDSLVSMKCSLFRFCPWSKELPFQPPEGSISSHLGSGASDSETEETRKALPIQSFSHEKESHQHRQHSVPVISRPGSNVKPTLPPIPQGRR |
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Interacts (via guanylate kinase-like domain) with RIMBP3 (via coiled-coil region). Interacts (via guanylate kinase-like domain) with HOOK2. Interacts (via LRRCT domain) with KLC3. Interacts with HOOK1 and HOOK3.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q96M69 | HOOK2 Q96ED9-2 | 3 | EBI-9478535, EBI-10961706 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias, repeat, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 73-96 | Disordered | ||||
Sequence: DSDGDEDQGEGEAGSEESSESEML | ||||||
Compositional bias | 75-96 | Acidic residues | ||||
Sequence: DGDEDQGEGEAGSEESSESEML | ||||||
Repeat | 129-149 | LRR 1 | ||||
Sequence: YLNLTLSGCNLIDVSILCGYV | ||||||
Repeat | 150-171 | LRR 2 | ||||
Sequence: HLQKLDLSANKIEDLSCVSCMP | ||||||
Repeat | 172-193 | LRR 3 | ||||
Sequence: YLLELNASQNNLTTFFNFKPPK | ||||||
Repeat | 194-215 | LRR 4 | ||||
Sequence: NLKKADFSHNQISEICDLSAYH | ||||||
Repeat | 216-237 | LRR 5 | ||||
Sequence: ALTKLILDGNEIEEISGLEMCN | ||||||
Repeat | 238-259 | LRR 6 | ||||
Sequence: NLIHLSLANNKITTINGLNKLP | ||||||
Repeat | 260-280 | LRR 7 | ||||
Sequence: IKILCLSNNQIEMITGLEDLK | ||||||
Repeat | 281-302 | LRR 8 | ||||
Sequence: ALQNLDLSHNQISSLQGLENHD | ||||||
Repeat | 303-324 | LRR 9 | ||||
Sequence: LLEVINLEDNKIAELREIEYIK | ||||||
Domain | 337-375 | LRRCT | ||||
Sequence: NPIQEKSEYWFFVIFMLLRLTELDQKKIKVEEKVSAVNK | ||||||
Domain | 414-597 | Guanylate kinase-like | ||||
Sequence: YPMLILAGPEACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFISQDVFDEMVNMGKFILTFSYGNHKYGLNRDTVEGIARDGLASCIHMEIEGVRSLKYSYFEPRYILVVPMNKEKYEGYLRRKGLFSRAEIEFAVSRVDLYIKINQNFPGYFDEVINADDLDVAYQKLSQLIR | ||||||
Region | 760-825 | Disordered | ||||
Sequence: PEGSISSHLGSGASDSETEETRKALPIQSFSHEKESHQHRQHSVPVISRPGSNVKPTLPPIPQGRR | ||||||
Compositional bias | 774-801 | Basic and acidic residues | ||||
Sequence: DSETEETRKALPIQSFSHEKESHQHRQH |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length825
- Mass (Da)93,618
- Last updated2001-12-01 v1
- Checksum3A66F149DFE15E2A
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2R8YEJ5 | A0A2R8YEJ5_HUMAN | LRGUK | 1130 | ||
A0A8Q3SIT3 | A0A8Q3SIT3_HUMAN | LRGUK | 56 | ||
A0A8Q3SI13 | A0A8Q3SI13_HUMAN | LRGUK | 1131 |
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 75-96 | Acidic residues | ||||
Sequence: DGDEDQGEGEAGSEESSESEML | ||||||
Sequence conflict | 606 | in Ref. 4; AAI04900/AAI04898 | ||||
Sequence: P → L | ||||||
Compositional bias | 774-801 | Basic and acidic residues | ||||
Sequence: DSETEETRKALPIQSFSHEKESHQHRQH |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK057348 EMBL· GenBank· DDBJ | BAB71441.1 EMBL· GenBank· DDBJ | mRNA | ||
CH236950 EMBL· GenBank· DDBJ | EAL24072.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471070 EMBL· GenBank· DDBJ | EAW83807.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC104897 EMBL· GenBank· DDBJ | AAI04898.1 EMBL· GenBank· DDBJ | mRNA | ||
BC104899 EMBL· GenBank· DDBJ | AAI04900.1 EMBL· GenBank· DDBJ | mRNA |