Q96KR4 · LMLN_HUMAN
- ProteinLeishmanolysin-like peptidase
- GeneLMLN
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids647 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Metalloprotease.
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | focal adhesion | |
Cellular Component | lipid droplet | |
Cellular Component | membrane | |
Molecular Function | metal ion binding | |
Molecular Function | metalloendopeptidase activity | |
Molecular Function | peptidase activity | |
Biological Process | cell adhesion | |
Biological Process | cell division | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameLeishmanolysin-like peptidase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ96KR4
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Found in ring-like structures resembling invadopodia. In migrating cells it relocalizes from internal structures to the leading edge of cells.
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_060158 | 98 | in dbSNP:rs7373165 | |||
Sequence: E → D |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 713 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000303076 | 1-647 | Leishmanolysin-like peptidase | |||
Sequence: MAAEWGGGVGYSGSGPGRSRWRWSGSVWVRSVLLLLGGLRASATSTPVSLGSSPPCRHHVPSDTEVINKVHLKANHVVKRDVDEHLRIKTVYDKSVEELLPEKKNLVKNKLFPQAISYLEKTFQVRRPAGTILLSRQCATNQYLRKENDPHRYCTGECAAHTKCGPVIVPEEHLQQCRVYRGGKWPHGAVGVPDQEGISDADFVLYVGALATERCSHENIISYAAYCQQEANMDRPIAGYANLCPNMISTQPQEFVGMLSTVKHEVIHALGFSAGLFAFYHDKDGNPLTSRFADGLPPFNYSLGLYQWSDKVVRKVERLWDVRDNKIVRHTVYLLVTPRVVEEARKHFDCPVLEGMELENQGGVGTELNHWEKRLLENEAMTGSHTQNRVLSRITLALMEDTGRQMLSPYCDTLRSNPLQLTCRQDQRAVAVCNLQKFPKPLPQEYQYFDELSGIPAEDLPYYGGSVEIADYCPFSQEFSWHLSGEYQRSSDCRILENQPEIFKNYGAEKYGPHSVCLIQKSAFVMEKCERKLSYPDWGSGCYQVSCSPQGLKVWVQDTSYLCSRAGQVLPVSIQMNGWIHDGNLLCPSCWDFCELCPPETDPPATNLTRALPLDLCSCSSSLVVTLWLLLGNLFPLLAGFLLCIWH |
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in all cell lines analyzed.
Gene expression databases
Organism-specific databases
Structure
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q96KR4-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length647
- Mass (Da)72,740
- Last updated2024-01-24 v3
- Checksum48FAC2E48FED6A8D
Q96KR4-2
- Name2
Q96KR4-3
- Name3
- Differences from canonical
- 403-403: G → GWYKANYSMAEKLDWGRGMGCDFVRKSCKFWIDQQRQK
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F8WCE5 | F8WCE5_HUMAN | LMLN | 415 | ||
C9JF40 | C9JF40_HUMAN | LMLN | 151 | ||
A0AAA9XCN5 | A0AAA9XCN5_HUMAN | LMLN | 452 |
Sequence caution
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_028002 | 1-65 | in isoform 2 | |||
Sequence: MAAEWGGGVGYSGSGPGRSRWRWSGSVWVRSVLLLLGGLRASATSTPVSLGSSPPCRHHVPSDTE → MGRRSGLLGLRPGPEPVALER | ||||||
Alternative sequence | VSP_028003 | 403 | in isoform 2 and isoform 3 | |||
Sequence: G → GWYKANYSMAEKLDWGRGMGCDFVRKSCKFWIDQQRQK | ||||||
Sequence conflict | 531 | in Ref. 1; CAP49203/CAP49204 and 2; CAC42882/CAC42883 | ||||
Sequence: R → K |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AM920777 EMBL· GenBank· DDBJ | CAP49203.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AM920778 EMBL· GenBank· DDBJ | CAP49204.1 EMBL· GenBank· DDBJ | mRNA | ||
AJ312398 EMBL· GenBank· DDBJ | CAC42882.1 EMBL· GenBank· DDBJ | mRNA | ||
AJ312399 EMBL· GenBank· DDBJ | CAC42883.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AC135893 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |