Q96JK9 · MAML3_HUMAN

  • Protein
    Mastermind-like protein 3
  • Gene
    MAML3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnuclear speck
Cellular Componentnucleoplasm
Cellular Componentnucleus
Molecular Functiontranscription coactivator activity
Biological ProcessNotch signaling pathway
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processpositive regulation of transcription of Notch receptor target

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Mastermind-like protein 3
  • Short names
    Mam-3

Gene names

    • Name
      MAML3
    • Synonyms
      KIAA1816

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q96JK9
  • Secondary accessions
    • B2RNU9
    • B3KVV7
    • E7EVW8

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_046650768

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1,250 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data), modified residue.

TypeIDPosition(s)SourceDescription
ChainPRO_00001294961-1138UniProtMastermind-like protein 3
Modified residue (large scale data)170PRIDEPhosphoserine
Modified residue (large scale data)351PRIDEPhosphoserine
Modified residue (large scale data)362PRIDEPhosphoserine
Modified residue (large scale data)364PRIDEPhosphoserine
Modified residue (large scale data)370PRIDEPhosphoserine
Modified residue (large scale data)373PRIDEPhosphoserine
Modified residue603UniProtN6-acetyllysine
Modified residue (large scale data)617PRIDEPhosphothreonine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Interacts through its N-terminal region with the ankyrin repeat region of the Notch proteins NOTCH1, NOTCH2, NOTCH3 and NOTCH4. Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q96JK9NOTCH1 PRO_0000007676 P465312EBI-1043855, EBI-9692333

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region37-68Disordered
Region119-148Disordered
Compositional bias126-148Polar residues
Region169-188Disordered
Compositional bias171-185Polar residues
Region207-237Disordered
Region334-480Disordered
Compositional bias344-426Polar residues
Compositional bias463-480Polar residues
Compositional bias503-523Polar residues
Region503-547Disordered
Compositional bias615-651Polar residues
Region615-662Disordered
Region691-721Disordered
Compositional bias702-716Polar residues
Region968-991Disordered
Region1024-1084Disordered
Compositional bias1033-1048Polar residues
Compositional bias1062-1084Polar residues
Region1090-1109Disordered

Domain

The C-terminal domain is required for transcriptional activation.

Sequence similarities

Belongs to the mastermind family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,138
  • Mass (Da)
    122,293
  • Last updated
    2014-09-03 v4
  • Checksum
    145C1CA5F2F7EEB0
MGDFAAPAAAANGSSICINSSLNSSLGGAGIGVNNTPNSTPAAPSSNHPAAGGCGGSGGPGGGSAAVPKHSTVVERLRQRIEGCRRHHVNCENRYQQAQVEQLELERRDTVSLYQRTLEQRAKKSGAGTGKQQHPSKPQQDAEAASAEQRNHTLIMLQETVKRKLEGARSPLNGDQQNGACDGNFSPTSKRIRKDISAGMEAINNLPSNMPLPSASPLHQLDLKPSLPLQNSGTHTPGLLEDLSKNGRLPEIKLPVNGCSDLEDSFTILQSKDLKQEPLDDPTCIDTSETSLSNQNKLFSDINLNDQEWQELIDELANTVPEDDIQDLFNEDFEEKKEPEFSQPATETPLSQESASVKSDPSHSPFAHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAVQSPQTPNQAHTPGQAPPRPGNGYLLNPAAVTVAGSASGPVAVPSSDMSPAEQLKQMAAQQQQRAKLMQQKQQQQQQQQQQQQQQQQQQQQQQQQQHSNQTSNWSPLGPPSSPYGAAFTAEKPNSPMMYPQAFNNQNPIVPPMANNLQKTTMNNYLPQNHMNMINQQPNNLGTNSLNKQHNILTYGNTKPLTHFNADLSQRMTPPVANPNKNPLMPYIQQQQQQQQQQQQQQQQQQPPPPQLQAPRAHLSEDQKRLLLMKQKGVMNQPMAYAALPSHGQEQHPVGLPRTTGPMQSSVPPGSGGMVSGASPAGPGFLGSQPQAAIMKQMLIDQRAQLIEQQKQQFLREQRQQQQQQQQQILAEQQLQQSHLPRQHLQPQRNPYPVQQVNQFQGSPQDIAAVRSQAALQSMRTSRLMAQNAGMMGIGPSQNPGTMATAAAQSEMGLAPYSTTPTSQPGMYNMSTGMTQMLQHPNQSGMSITHNQAQGPRQPASGQGVGMVSGFGQSMLVNSAITQQHPQMKGPVGQALPRPQAPPRLQSLMGTVQQGAQSWQQRSLQGMPGRTSGELGPFNNGASYPLQAGQPRLTKQHFPQGLSQSVVDANTGTVRTLNPAAMGRQMMPSLPGQQGTSQARPMVMSGLSQGVPGMPAFSQPPAQQQIPSGSFAPSSQSQAYERNAPQDVSYNYSGDGAGGSFPGLPDGADLVDSIIKGGPGDEWMQELDELFGNP

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
H0Y920H0Y920_HUMANMAML3186

Sequence caution

The sequence BAB47445.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.
The sequence BAG53919.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias126-148Polar residues
Compositional bias171-185Polar residues
Compositional bias344-426Polar residues
Compositional bias463-480Polar residues
Sequence conflict486-489in Ref. 1; BAB47445, 2; BAG53919, 4; EAX05107 and 5; AAI37132/AAI37131
Compositional bias503-523Polar residues
Compositional bias615-651Polar residues
Compositional bias702-716Polar residues
Compositional bias1033-1048Polar residues
Compositional bias1062-1084Polar residues
Sequence conflict1064in Ref. 1; BAB47445 and 2; BAG53919

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB058719
EMBL· GenBank· DDBJ
BAB47445.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK123604
EMBL· GenBank· DDBJ
BAG53919.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AC097464
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC104798
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC108053
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC131182
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471056
EMBL· GenBank· DDBJ
EAX05107.1
EMBL· GenBank· DDBJ
Genomic DNA
BC137130
EMBL· GenBank· DDBJ
AAI37131.1
EMBL· GenBank· DDBJ
mRNA
BC137131
EMBL· GenBank· DDBJ
AAI37132.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp