Q96JB3 · HIC2_HUMAN
- ProteinHypermethylated in cancer 2 protein
- GeneHIC2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids615 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Transcriptional repressor.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleoplasm | |
Cellular Component | nucleus | |
Cellular Component | plasma membrane | |
Molecular Function | DNA binding | |
Molecular Function | DNA-binding transcription repressor activity, RNA polymerase II-specific | |
Molecular Function | metal ion binding | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Biological Process | negative regulation of DNA-templated transcription | |
Biological Process | negative regulation of transcription by RNA polymerase II | |
Biological Process | regulation of cytokine production | |
Biological Process | regulation of immune system process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHypermethylated in cancer 2 protein
- Short namesHic-2
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ96JB3
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 728 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000046945 | 1-615 | UniProt | Hypermethylated in cancer 2 protein | |||
Sequence: MVSGPLALRWCAWAGRGDMGPDMELPSHSKQLLLQLNQQRTKGFLCDVIIMVENSIFRAHKNVLAASSIYFKSLVLHDNLINLDTDMVSSTVFQQILDFIYTGKLLPSDQPAEPNFSTLLTAASYLQLPELAALCRRKLKRAGKPFGSGRAGSTGMGRPPRSQRLSTASVIQARYQGLVDGRKGAHAPQELPQAKGSDDELFLGGSNQDSVQGLGRAVCPAGGEAGLGGCSSSTNGSSGGCEQELGLDLSKKSPPLPPATPGPHLTPDDAAQLSDSQHGSPPAASAPPVANSASYSELGGTPDEPMDLEGAEDNHLSLLEAPGGQPRKSLRHSTRKKEWGKKEPVAGSPFERREAGPKGPCPGEEGEGVGDRVPNGILASGAGPSGPYGEPPYPCKEEEENGKDASEDSAQSGSEGGSGHASAHYMYRQEGYETVSYGDNLYVCIPCAKGFPSSEQLNAHVETHTEEELFIKEEGAYETGSGGAEEEAEDLSAPSAAYTAEPRPFKCSVCEKTYKDPATLRQHEKTHWLTRPFPCNICGKMFTQRGTMTRHMRSHLGLKPFACDECGMRFTRQYRLTEHMRVHSGEKPYECQLCGGKFTQQRNLISHLRMHTSPS | |||||||
Modified residue | 166 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 169 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 197 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 197 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 348 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 348 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 412 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 481 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Subunit
Self-associates. Interacts with HIC1.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q96JB3 | CEP70 Q8NHQ1 | 3 | EBI-726282, EBI-739624 | |
BINARY | Q96JB3 | EHMT2 Q96KQ7 | 3 | EBI-726282, EBI-744366 | |
BINARY | Q96JB3 | ZBTB8A Q96BR9 | 5 | EBI-726282, EBI-742740 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 46-109 | BTB | ||||
Sequence: CDVIIMVENSIFRAHKNVLAASSIYFKSLVLHDNLINLDTDMVSSTVFQQILDFIYTGKLLPSD | ||||||
Region | 144-167 | Disordered | ||||
Sequence: KPFGSGRAGSTGMGRPPRSQRLST | ||||||
Region | 182-208 | Disordered | ||||
Sequence: RKGAHAPQELPQAKGSDDELFLGGSNQ | ||||||
Region | 229-421 | Disordered | ||||
Sequence: GCSSSTNGSSGGCEQELGLDLSKKSPPLPPATPGPHLTPDDAAQLSDSQHGSPPAASAPPVANSASYSELGGTPDEPMDLEGAEDNHLSLLEAPGGQPRKSLRHSTRKKEWGKKEPVAGSPFERREAGPKGPCPGEEGEGVGDRVPNGILASGAGPSGPYGEPPYPCKEEEENGKDASEDSAQSGSEGGSGHA | ||||||
Region | 246-250 | Binding to CtBP | ||||
Sequence: GLDLS | ||||||
Compositional bias | 270-298 | Polar residues | ||||
Sequence: AAQLSDSQHGSPPAASAPPVANSASYSEL | ||||||
Zinc finger | 442-469 | C2H2-type 1 | ||||
Sequence: YVCIPCAKGFPSSEQLNAHVETHTEEEL | ||||||
Zinc finger | 505-532 | C2H2-type 2 | ||||
Sequence: FKCSVCEKTYKDPATLRQHEKTHWLTRP | ||||||
Zinc finger | 533-560 | C2H2-type 3 | ||||
Sequence: FPCNICGKMFTQRGTMTRHMRSHLGLKP | ||||||
Zinc finger | 561-588 | C2H2-type 4 | ||||
Sequence: FACDECGMRFTRQYRLTEHMRVHSGEKP | ||||||
Zinc finger | 589-615 | C2H2-type 5 | ||||
Sequence: YECQLCGGKFTQQRNLISHLRMHTSPS |
Sequence similarities
Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q96JB3-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length615
- Mass (Da)66,156
- Last updated2002-05-02 v2
- ChecksumB0368C631B198C95
Q96JB3-2
- Name2
- Differences from canonical
- 1-18: Missing
Sequence caution
Features
Showing features for alternative sequence, sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_006829 | 1-18 | in isoform 2 | |||
Sequence: Missing | ||||||
Sequence conflict | 49-51 | in Ref. 1; CAC70715 | ||||
Sequence: IIM → TIR | ||||||
Sequence conflict | 176 | in Ref. 3; BAA82972 | ||||
Sequence: Q → R | ||||||
Compositional bias | 270-298 | Polar residues | ||||
Sequence: AAQLSDSQHGSPPAASAPPVANSASYSEL |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ313204 EMBL· GenBank· DDBJ | CAC70715.1 EMBL· GenBank· DDBJ | mRNA | ||
AF349035 EMBL· GenBank· DDBJ | AAK72951.1 EMBL· GenBank· DDBJ | mRNA | ||
AB028943 EMBL· GenBank· DDBJ | BAA82972.2 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
CR456377 EMBL· GenBank· DDBJ | CAG30263.1 EMBL· GenBank· DDBJ | mRNA | ||
AP000557 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC094787 EMBL· GenBank· DDBJ | AAH94787.1 EMBL· GenBank· DDBJ | mRNA | ||
AL162003 EMBL· GenBank· DDBJ | CAB82344.1 EMBL· GenBank· DDBJ | mRNA |