Q96HD9 · ACY3_HUMAN

  • Protein
    N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)
  • Gene
    ACY3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acids (By similarity).

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site21Zn2+ (UniProtKB | ChEBI)
Binding site24Zn2+ (UniProtKB | ChEBI)
Binding site63substrate
Binding site70-71substrate
Binding site116Zn2+ (UniProtKB | ChEBI)
Binding site178substrate
Binding site288substrate

GO annotations

AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentcytosol
Cellular Componentextracellular exosome
Molecular Functionaminoacylase activity
Molecular Functionhydrolase activity, acting on ester bonds
Molecular Functionidentical protein binding
Molecular Functionmetal ion binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)
  • EC number
  • Alternative names
    • Acylase III
    • Aminoacylase-3 (ACY-3)
    • Aspartoacylase-2
    • Hepatitis C virus core-binding protein 1 (HCBP1; HCV core-binding protein 1)

Gene names

    • Name
      ACY3
    • Synonyms
      ASPA2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q96HD9

Proteomes

Organism-specific databases

Subcellular Location

Apical cell membrane
; Peripheral membrane protein
Cytoplasm
Note: Predominantly localized in the apical membrane of cells in the S1 segment. In the proximal straight tubules (S2 and S3 segments) is expressed diffusely throughout the cytoplasm.

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_0483418in dbSNP:rs948445
Natural variantVAR_048342281in dbSNP:rs2290959

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 429 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002168751-319N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-210Hydrolytic domain
Region211-318Shielding domain

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    319
  • Mass (Da)
    35,241
  • Last updated
    2001-12-01 v1
  • Checksum
    2595358AC8B5BEFB
MCSLPVPREPLRRVAVTGGTHGNEMSGVYLARHWLHAPAELQRASFSAVPVLANPAATSGCRRYVDHDLNRTFTSSFLNSRPTPDDPYEVTRARELNQLLGPKASGQAFDFVLDLHNTTANMGTCLIAKSSHEVFAMHLCRHLQLQYPELSCQVFLYQRSGEESYNLDSVAKNGLGLELGPQPQGVLRADIFSRMRTLVATVLDFIELFNQGTAFPAFEMEAYRPVGVVDFPRTEAGHLAGTVHPQLQDRDFQPLQPGAPIFQMFSGEDLLYEGESTVYPVFINEAAYYEKGVAFVQTEKFTFTVPAMPALTPAPSPAS

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
E9PRA7E9PRA7_HUMANACY3198

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY040761
EMBL· GenBank· DDBJ
AAK94770.1
EMBL· GenBank· DDBJ
mRNA
AY169233
EMBL· GenBank· DDBJ
AAN87896.1
EMBL· GenBank· DDBJ
mRNA
BC008689
EMBL· GenBank· DDBJ
AAH08689.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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