Q96GS4 · BORC6_HUMAN

  • Protein
    BLOC-1-related complex subunit 6
  • Gene
    BORCS6
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentBORC complex
Cellular Componentcytoplasmic side of lysosomal membrane
Molecular Functionidentical protein binding
Biological Processlysosome localization
Biological Processorganelle transport along microtubule
Biological Processregulation of endosome size
Biological Processregulation of lysosome size

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    BLOC-1-related complex subunit 6
  • Alternative names
    • Lysosome-dispersing protein
      (Lyspersin
      )

Gene names

    • Name
      BORCS6
    • Synonyms
      C17orf59

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q96GS4
  • Secondary accessions
    • Q53HS4
    • Q9NXW8

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 445 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data), modified residue.

TypeIDPosition(s)SourceDescription
ChainPRO_00002868271-357UniProt
Modified residue (large scale data)43PRIDEPhosphoserine
Modified residue (large scale data)93PRIDEPhosphoserine
Modified residue (large scale data)160PRIDEPhosphoserine
Modified residue (large scale data)166PRIDEPhosphoserine
Modified residue168UniProtPhosphoserine
Modified residue (large scale data)168PRIDEPhosphoserine
Modified residue (large scale data)173PRIDEPhosphoserine
Modified residue196UniProtPhosphothreonine
Modified residue (large scale data)196PRIDEPhosphothreonine
Modified residue (large scale data)198PRIDEPhosphoserine
Modified residue199UniProtPhosphoserine
Modified residue (large scale data)199PRIDEPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Component of the BLOC-one-related complex (BORC) which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q96GS4ABI2 Q9NYB9-25EBI-10193358, EBI-11096309
BINARY Q96GS4AIRIM Q9NX043EBI-10193358, EBI-8643161
BINARY Q96GS4BEX2 Q9BXY83EBI-10193358, EBI-745073
BINARY Q96GS4BORCS6 Q96GS43EBI-10193358, EBI-10193358
BINARY Q96GS4C19orf25 Q9UFG53EBI-10193358, EBI-741214
BINARY Q96GS4C1orf216 Q8TAB53EBI-10193358, EBI-747505
BINARY Q96GS4CCHCR1 Q8TD31-33EBI-10193358, EBI-10175300
BINARY Q96GS4DCTN2 Q135614EBI-10193358, EBI-715074
BINARY Q96GS4DISC1 Q9NRI5-24EBI-10193358, EBI-11988027
BINARY Q96GS4EPS8 Q129293EBI-10193358, EBI-375576
BINARY Q96GS4EXOC8 Q8IYI63EBI-10193358, EBI-742102
BINARY Q96GS4EXOSC5 Q9NQT43EBI-10193358, EBI-371876
BINARY Q96GS4FAM161B Q96MY73EBI-10193358, EBI-7225287
BINARY Q96GS4FAM9C Q8IZT93EBI-10193358, EBI-2870039
BINARY Q96GS4FBXO44 Q9H4M34EBI-10193358, EBI-2322644
BINARY Q96GS4FBXO44 Q9H4M3-28EBI-10193358, EBI-12104696
BINARY Q96GS4FCHSD2 O94868-34EBI-10193358, EBI-11958845
BINARY Q96GS4GAS8 O959953EBI-10193358, EBI-1052570
BINARY Q96GS4HAUS1 Q96CS23EBI-10193358, EBI-2514791
BINARY Q96GS4HGS O149643EBI-10193358, EBI-740220
BINARY Q96GS4INSYN1 Q2T9L44EBI-10193358, EBI-4311436
BINARY Q96GS4KANK2 Q63ZY33EBI-10193358, EBI-2556193
BINARY Q96GS4KXD1 Q9BQD37EBI-10193358, EBI-739657
BINARY Q96GS4LAMTOR2 Q9Y2Q57EBI-10193358, EBI-2643704
BINARY Q96GS4LNX1 Q8TBB13EBI-10193358, EBI-739832
BINARY Q96GS4MED21 Q135033EBI-10193358, EBI-394678
BINARY Q96GS4MOS P005404EBI-10193358, EBI-1757866
BINARY Q96GS4NDEL1 Q9GZM86EBI-10193358, EBI-928842
BINARY Q96GS4NTAQ1 Q96HA83EBI-10193358, EBI-741158
BINARY Q96GS4PKNOX1 P553474EBI-10193358, EBI-1373569
BINARY Q96GS4RCOR3 Q9P2K3-23EBI-10193358, EBI-1504830
BINARY Q96GS4RIBC1 Q8N4433EBI-10193358, EBI-10265323
BINARY Q96GS4SHPRH Q149N83EBI-10193358, EBI-714105
BINARY Q96GS4SPG21 Q9NZD83EBI-10193358, EBI-742688
BINARY Q96GS4TACC2 B2RWP46EBI-10193358, EBI-14211313
BINARY Q96GS4USHBP1 Q8N6Y03EBI-10193358, EBI-739895
BINARY Q96GS4VPS52 Q8N1B43EBI-10193358, EBI-2799833
BINARY Q96GS4ZNF655 Q8N7203EBI-10193358, EBI-625509

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region20-196Disordered
Region227-256Disordered
Compositional bias228-256Pro residues

Sequence similarities

Belongs to the BORCS6 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    357
  • Mass (Da)
    37,226
  • Last updated
    2010-05-18 v2
  • Checksum
    BBA89770528FA9E9
MESSRGRPGPETDLLAVAEHQALVFGGGPGRTSSEPPAGLRVSGEEETENVGGANRHPRTSPKTSSCGVVHRPEREALENEPGPQGTLSGAGSRRGAPGAEHEPSLSSRHKNPAPPEGKPSSGRDCRRGGPGGGMDVEQQEEEDNDEEAAAGSRAGRSFSSRLQDSRSLDGLSEACGGAGSSGSAESGAGGGRRATISSPLELEGTVSRHGDLTHFVANNLQLKIRLSGAPPPPPSAPARPCPAPAPTPTPAIPPIDPEVLRDLERLSRELGGRVDRLLRGLGGAVQELTALSVGCIQTYRDAVDSLGEAVDMSIKGMYTLLARCEELERALQPVQGLARQVRDIRRTLEVLEALCK

Sequence caution

The sequence AAH09261.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence AAH18880.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence AAH70272.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence BAA90889.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence BAD96226.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict202in Ref. 3; BAA90889
Compositional bias228-256Pro residues
Sequence conflict336in Ref. 3; BAA90889 and 4; BAD96226

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC129492
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC009261
EMBL· GenBank· DDBJ
AAH09261.1
EMBL· GenBank· DDBJ
mRNA Different initiation
BC018880
EMBL· GenBank· DDBJ
AAH18880.1
EMBL· GenBank· DDBJ
mRNA Different initiation
BC070272
EMBL· GenBank· DDBJ
AAH70272.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK000021
EMBL· GenBank· DDBJ
BAA90889.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK222506
EMBL· GenBank· DDBJ
BAD96226.1
EMBL· GenBank· DDBJ
mRNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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