Q96GE6 · CALL4_HUMAN

  • Protein
    Calmodulin-like protein 4
  • Gene
    CALML4
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. Acts as a light chain for MYO7B and is required for efficient targeting of the IMAC to the tips of border brush microvilli.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmicrovillus
Molecular Functioncalcium ion binding
Molecular Functionenzyme regulator activity
Molecular Functionmyosin head/neck binding
Biological Processbrush border assembly

Enzyme and pathway databases

Community curation (1)

As part of the intermicrovillar adhesion complex (IMAC), it plays a role in epithelial brush border differentiation. It plays a role in targeting of the complex. It interacts with MYO7B; the interaction is direct and is required for MYO7B localization to the tip of microvilli.

Names & Taxonomy

Protein names

  • Recommended name
    Calmodulin-like protein 4
  • Alternative names
    • Serologically defined breast cancer antigen NY-BR-20

Gene names

    • Name
      CALML4
Community curation (1)

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q96GE6
  • Secondary accessions
    • B4DL15
    • F8W6Y4
    • Q6MZY3
    • Q6N048
    • Q9H286

Proteomes

Organism-specific databases

Subcellular Location

Isoform 1

Note: Enriched at the distal tips of enterocyte microvilli.

Isoform 6

Note: Enriched at the distal tips of enterocyte microvilli.

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_04858628in dbSNP:rs3803381
Natural variantVAR_048587154in dbSNP:rs2280217

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 2 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003149331-196Calmodulin-like protein 4

Proteomic databases

PTM databases

Expression

Tissue specificity

Isoform 1

Expressed in the intestinal tract.

Isoform 6

Dominant transcript in the intestinal tract.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Interacts with MYO7B; the interaction mediates the association of CALML4 with the IMAC/intermicrovillar adhesion complex (PubMed:32209652).
Interacts with MYO7A (PubMed:32209652).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-43Disordered
Compositional bias29-43Polar residues
Domain51-86EF-hand 1
Domain87-122EF-hand 2
Domain124-159EF-hand 3
Domain160-195EF-hand 4

Sequence similarities

Belongs to the calmodulin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (6)
  • Sequence status
    Complete

This entry describes 6 isoforms produced by Alternative splicing.

Q96GE6-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    Long
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    196
  • Mass (Da)
    21,883
  • Last updated
    2008-10-14 v3
  • Checksum
    547C558AC7EDFABD
MAAEHLLPGPPPSLADFRLEAGGKGTERGSGSSKPTGSSRGPRMAKFLSQDQINEYKECFSLYDKQQRGKIKATDLMVAMRCLGASPTPGEVQRHLQTHGIDGNGELDFSTFLTIMHMQIKQEDPKKEILLAMLMVDKEKKGYVMASDLRSKLTSLGEKLTHKEVDDLFREADIEPNGKVKYDEFIHKITLPGRDY

Q96GE6-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q96GE6-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q96GE6-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q96GE6-5

  • Name
    5
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 45-59: AKFLSQDQINEYKEC → WMISSGKQISNPMAK
    • 60-196: Missing

Q96GE6-6

  • Name
    6
  • Synonyms
    Short
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
H3BS46H3BS46_HUMANCALML488
H3BM29H3BM29_HUMANCALML460
A0A804D2Q3A0A804D2Q3_HUMANCALML4106
A0A804DNR1A0A804DNR1_HUMANCALML4153

Sequence caution

The sequence AAG48255.1 differs from that shown. Reason: Frameshift
The sequence BAG59377.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Features

Showing features for alternative sequence, compositional bias, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0622621-43in isoform 6
Alternative sequenceVSP_0304361-76in isoform 2
Alternative sequenceVSP_0304351-115in isoform 3
Compositional bias29-43Polar residues
Sequence conflict40in Ref. 1; AAG48255
Alternative sequenceVSP_05551345-59in isoform 5
Alternative sequenceVSP_04715055-101in isoform 4
Sequence conflict60in Ref. 1; AAG48255
Alternative sequenceVSP_05551460-196in isoform 5
Sequence conflict76in Ref. 1; AAG48255

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF308287
EMBL· GenBank· DDBJ
AAG48255.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
CR598967
EMBL· GenBank· DDBJ
-mRNA No translation available.
BX640702
EMBL· GenBank· DDBJ
CAE45822.1
EMBL· GenBank· DDBJ
mRNA
BX640817
EMBL· GenBank· DDBJ
CAE45894.1
EMBL· GenBank· DDBJ
mRNA
AC107871
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471082
EMBL· GenBank· DDBJ
EAW77810.1
EMBL· GenBank· DDBJ
Genomic DNA
BC009516
EMBL· GenBank· DDBJ
-mRNA No translation available.
AK296804
EMBL· GenBank· DDBJ
BAG59377.1
EMBL· GenBank· DDBJ
mRNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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