Q96DX7 · TRI44_HUMAN
- ProteinTripartite motif-containing protein 44
- GeneTRIM44
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids344 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May play a role in the process of differentiation and maturation of neuronal cells (By similarity).
May regulate the activity of TRIM17. Is a negative regulator of PAX6 expression (PubMed:26394807).
May regulate the activity of TRIM17. Is a negative regulator of PAX6 expression (PubMed:26394807).
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ubiquitin protein ligase activity | |
Molecular Function | zinc ion binding | |
Biological Process | negative regulation of protein K48-linked ubiquitination | |
Biological Process | positive regulation of cytokine-mediated signaling pathway | |
Biological Process | positive regulation of defense response to virus by host | |
Biological Process | positive regulation of DNA-templated transcription | |
Biological Process | positive regulation of non-canonical NF-kappaB signal transduction | |
Biological Process | protein stabilization | |
Biological Process | protein ubiquitination | |
Biological Process | regulation of gene expression | |
Biological Process | response to angiotensin |
Keywords
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTripartite motif-containing protein 44
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ96DX7
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Disease & Variants
Involvement in disease
Aniridia 3 (AN3)
- Note
- DescriptionA form of aniridia, a congenital, bilateral, panocular disorder characterized by complete absence of the iris or extreme iris hypoplasia. Aniridia is not just an isolated defect in iris development but it is associated with macular and optic nerve hypoplasia, cataract, corneal changes, nystagmus. Visual acuity is generally low but is unrelated to the degree of iris hypoplasia. Glaucoma is a secondary problem causing additional visual loss over time.
- See alsoMIM:617142
Natural variants in AN3
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_077853 | 155 | G>R | in AN3; affects function and results in increased negative regulation of PAX6 expression compared to wild-type; dbSNP:rs886039241 |
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_077852 | 64 | does not affect function in negative regulation of PAX6 expression; dbSNP:rs377117775 | |||
Sequence: S → Y | ||||||
Natural variant | VAR_077853 | 155 | in AN3; affects function and results in increased negative regulation of PAX6 expression compared to wild-type; dbSNP:rs886039241 | |||
Sequence: G → R |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 397 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data), modified residue.
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000220372 | 1-344 | UniProt | Tripartite motif-containing protein 44 | |||
Sequence: MASGVGAAFEELPHDGTCDECEPDEAPGAEEVCRECGFCYCRRHAEAHRQKFLSHHLAEYVHGSQAWTPPADGEGAGKEEAEVKVEQEREIESEAGEESESEEESESEEESETEEESEDESDEESEEDSEEEMEDEQESEAEEDNQEEGESEAEGETEAESEFDPEIEMEAERVAKRKCPDHGLDLSTYCQEDRQLICVLCPVIGAHQGHQLSTLDEAFEELRSKDSGGLKAAMIELVERLKFKSSDPKVTRDQMKMFIQQEFKKVQKVIADEEQKALHLVDIQEAMATAHVTEILADIQSHMDRLMTQMAQAKEQLDTSNESAEPKAEGDEEGPSGASEEEDT | |||||||
Modified residue (large scale data) | 68 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 319 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 320 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 323 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 336 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 336 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 339 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 339 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Subunit
Interacts (via coiled coil) with TRIM17 (via coiled coil).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q96DX7 | MORN4 Q8NDC4 | 3 | EBI-8787399, EBI-10269566 | |
BINARY | Q96DX7 | PBX3 Q5JS98 | 3 | EBI-8787399, EBI-10244393 | |
BINARY | Q96DX7 | PICK1 Q9NRD5 | 3 | EBI-8787399, EBI-79165 | |
BINARY | Q96DX7 | TRIM10 Q9UDY6-2 | 4 | EBI-8787399, EBI-11981577 | |
BINARY | Q96DX7 | TRIM69 Q86WT6 | 3 | EBI-8787399, EBI-749955 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias, zinc finger, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-25 | Disordered | ||||
Sequence: MASGVGAAFEELPHDGTCDECEPDE | ||||||
Region | 66-165 | Disordered | ||||
Sequence: AWTPPADGEGAGKEEAEVKVEQEREIESEAGEESESEEESESEEESETEEESEDESDEESEEDSEEEMEDEQESEAEEDNQEEGESEAEGETEAESEFDP | ||||||
Compositional bias | 75-91 | Basic and acidic residues | ||||
Sequence: GAGKEEAEVKVEQEREI | ||||||
Compositional bias | 92-165 | Acidic residues | ||||
Sequence: ESEAGEESESEEESESEEESETEEESEDESDEESEEDSEEEMEDEQESEAEEDNQEEGESEAEGETEAESEFDP | ||||||
Zinc finger | 174-215 | B box-type | ||||
Sequence: VAKRKCPDHGLDLSTYCQEDRQLICVLCPVIGAHQGHQLSTL | ||||||
Coiled coil | 290-325 | |||||
Sequence: AHVTEILADIQSHMDRLMTQMAQAKEQLDTSNESAE | ||||||
Region | 309-344 | Disordered | ||||
Sequence: QMAQAKEQLDTSNESAEPKAEGDEEGPSGASEEEDT | ||||||
Compositional bias | 320-334 | Basic and acidic residues | ||||
Sequence: SNESAEPKAEGDEEG |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length344
- Mass (Da)38,472
- Last updated2001-12-01 v1
- Checksum5DC26DD73C347AF1
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 41 | in Ref. 1; CAB65108 | ||||
Sequence: C → S | ||||||
Compositional bias | 75-91 | Basic and acidic residues | ||||
Sequence: GAGKEEAEVKVEQEREI | ||||||
Compositional bias | 92-165 | Acidic residues | ||||
Sequence: ESEAGEESESEEESESEEESETEEESEDESDEESEEDSEEEMEDEQESEAEEDNQEEGESEAEGETEAESEFDP | ||||||
Sequence conflict | 232 | in Ref. 1; CAB65108 | ||||
Sequence: A → G | ||||||
Compositional bias | 320-334 | Basic and acidic residues | ||||
Sequence: SNESAEPKAEGDEEG |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ249128 EMBL· GenBank· DDBJ | CAB65108.1 EMBL· GenBank· DDBJ | mRNA | ||
AL138812 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471064 EMBL· GenBank· DDBJ | EAW68133.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471064 EMBL· GenBank· DDBJ | EAW68134.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC013166 EMBL· GenBank· DDBJ | AAH13166.1 EMBL· GenBank· DDBJ | mRNA | ||
BC024031 EMBL· GenBank· DDBJ | AAH24031.1 EMBL· GenBank· DDBJ | mRNA |