Q96DV4 · RM38_HUMAN
- ProteinLarge ribosomal subunit protein mL38
- GeneMRPL38
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids380 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | mitochondrial inner membrane | |
Cellular Component | mitochondrial large ribosomal subunit | |
Cellular Component | mitochondrion | |
Biological Process | mitochondrial translation |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLarge ribosomal subunit protein mL38
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ96DV4
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_059808 | 99 | in dbSNP:rs34136221 | |||
Sequence: R → W | ||||||
Natural variant | VAR_029472 | 371 | in dbSNP:rs9191 | |||
Sequence: D → H |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 481 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for transit peptide, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transit peptide | 1-26 | Mitochondrion | ||||
Sequence: MAAPWWRAALCECRRWRGFSTSAVLG | ||||||
Chain | PRO_0000261652 | 27-380 | Large ribosomal subunit protein mL38 | |||
Sequence: RRTPPLGPMPNSDIDLSNLERLEKYRSFDRYRRRAEQEAQAPHWWRTYREYFGEKTDPKEKIDIGLPPPKVSRTQQLLERKQAIQELRANVEEERAARLRTASVPLDAVRAEWERTCGPYHKQRLAEYYGLYRDLFHGATFVPRVPLHVAYAVGEDDLMPVYCGNEVTPTEAAQAPEVTYEAEEGSLWTLLLTSLDGHLLEPDAEYLHWLLTNIPGNRVAEGQVTCPYLPPFPARGSGIHRLAFLLFKQDQPIDFSEDARPSPCYQLAQRTFRTFDFYKKHQETMTPAGLSFFQCRWDDSVTYIFHQLLDMREPVFEFVRPPPYHPKQKRFPHRQPLRYLDRYRDSHEPTYGIY |
Proteomic databases
PTM databases
Interaction
Subunit
Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:25278503, PubMed:25838379, PubMed:28892042, PubMed:35177605).
Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. mL38 is located at the central protuberance
Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. mL38 is located at the central protuberance
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q96DV4 | ARHGAP9 Q9BRR9 | 3 | EBI-720441, EBI-750254 | |
BINARY | Q96DV4 | BAG3 O95817 | 3 | EBI-720441, EBI-747185 | |
BINARY | Q96DV4 | BEX2 Q9BXY8 | 3 | EBI-720441, EBI-745073 | |
BINARY | Q96DV4 | CCDC120 Q96HB5 | 3 | EBI-720441, EBI-744556 | |
BINARY | Q96DV4 | CENATAC Q86UT8 | 3 | EBI-720441, EBI-11028020 | |
BINARY | Q96DV4 | ENKD1 Q9H0I2 | 3 | EBI-720441, EBI-744099 | |
BINARY | Q96DV4 | GADD45GIP1 Q8TAE8 | 5 | EBI-720441, EBI-372506 | |
BINARY | Q96DV4 | GOLGA6A Q9NYA3 | 3 | EBI-720441, EBI-11163335 | |
BINARY | Q96DV4 | LONRF1 Q17RB8 | 3 | EBI-720441, EBI-2341787 | |
BINARY | Q96DV4 | MKRN3 Q13064 | 3 | EBI-720441, EBI-2340269 | |
BINARY | Q96DV4 | MRPL18 Q9H0U6 | 6 | EBI-720441, EBI-2560240 | |
BINARY | Q96DV4 | MRPL52 Q86TS9 | 3 | EBI-720441, EBI-10977303 | |
BINARY | Q96DV4 | MYOZ3 Q8TDC0 | 3 | EBI-720441, EBI-5662487 | |
BINARY | Q96DV4 | PPP1R18 Q6NYC8 | 3 | EBI-720441, EBI-2557469 | |
BINARY | Q96DV4 | PRMT6 Q96LA8 | 3 | EBI-720441, EBI-912440 | |
BINARY | Q96DV4 | RALY Q53GL6 | 3 | EBI-720441, EBI-9512693 | |
BINARY | Q96DV4 | RPL13 P26373 | 2 | EBI-720441, EBI-356849 | |
BINARY | Q96DV4 | TSEN54 Q7Z6J9 | 3 | EBI-720441, EBI-2559824 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 99-127 | |||||
Sequence: RTQQLLERKQAIQELRANVEEERAARLRT |
Sequence similarities
Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 2 isoforms produced by Alternative splicing.
Q96DV4-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length380
- Mass (Da)44,597
- Last updated2006-11-28 v2
- Checksum7BC527A7E1C06A6C
Q96DV4-2
- Name2
- Differences from canonical
- 1-184: Missing
Sequence caution
Features
Showing features for alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_056090 | 1-184 | in isoform 2 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK024058 EMBL· GenBank· DDBJ | BAG51258.1 EMBL· GenBank· DDBJ | mRNA | ||
AC087289 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC013311 EMBL· GenBank· DDBJ | AAH13311.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AB051345 EMBL· GenBank· DDBJ | BAB54935.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF161380 EMBL· GenBank· DDBJ | AAF28940.1 EMBL· GenBank· DDBJ | mRNA |