our results suggested that increased ATG4C expression was associated with worse prognosis in glioma patients. Knockdown of ATG4C suppressed glioma progression by inducing cell cycle arrest and promoting apoptosis of glioma cells possibly through increasing ROS production.
We demonstrate that in breast cancer cells ATM and ATG4C are essential drivers of mammosphere formation suggesting that their targeting may improve current approaches to eradicate breast cancer cells with a stem-like phenotype.
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