Q96DN2 · VWCE_HUMAN
- Proteinvon Willebrand factor C and EGF domain-containing protein
- GeneVWCE
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids955 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | extracellular region | |
Molecular Function | calcium ion binding | |
Biological Process | cellular response to virus |
Keywords
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namevon Willebrand factor C and EGF domain-containing protein
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ96DN2
- Secondary accessions
Proteomes
Organism-specific databases
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_038782 | 842 | in dbSNP:rs3750982 | |||
Sequence: P → R |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,130 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-21 | |||||
Sequence: MWAGLLLRAACVALLLPGAPA | ||||||
Chain | PRO_0000318580 | 22-955 | von Willebrand factor C and EGF domain-containing protein | |||
Sequence: RGYTGRKPPGHFAAERRRLGPHVCLSGFGSGCCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEAGRPALSPGHSPPSGAPGPPAGVRTTRLPSPTPRLPTSSPSAPVWLLSTLLATPVPTASLLGNLRPPSLLQGEVMGTPSSPRGPESPRLAAGPSPCWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRCEAACSHPIPSRDGGCCPSCTGCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSCISPECPSGPCQTPPQTDCCTCVPVRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTCQEPTPSTGCSLDDNGVEFPIGQIWSPGDPCELCICQADGSVSCKRTDCVDSCPHPIRIPGQCCPDCSAGCTYTGRIFYNNETFPSVLDPCLSCICLLGSVACSPVDCPITCTYPFHPDGECCPVCRDCNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSCEKVPCQRACADPALLPGDCCSSCPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAPVNCSSCPGPPTASPSRPVLHLLQLLLRTNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTPPGAPTLPLASPGAPQPPPVTPERSFSASGAQIVSRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPPVGASRGEESTM | ||||||
Disulfide bond | 146↔155 | |||||
Sequence: CVTSSCEGHC | ||||||
Disulfide bond | 151↔164 | |||||
Sequence: CEGHCVNTEGGFVC | ||||||
Disulfide bond | 166↔179 | |||||
Sequence: CGPGMQLSADRHSC | ||||||
Disulfide bond | 185↔194 | |||||
Sequence: CLGTPCQQRC | ||||||
Disulfide bond | 190↔203 | |||||
Sequence: CQQRCKNSIGSYKC | ||||||
Disulfide bond | 205↔218 | |||||
Sequence: CRTGFHLHGNRHSC | ||||||
Disulfide bond | 224↔237 | |||||
Sequence: CRRPLERRVCHHSC | ||||||
Disulfide bond | 233↔246 | |||||
Sequence: CHHSCHNTVGSFLC | ||||||
Disulfide bond | 248↔261 | |||||
Sequence: CRPGFRLRADRVSC | ||||||
Glycosylation | 462 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 472 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in liver.
Induction
By HBxAg.
Gene expression databases
Organism-specific databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q96DN2 | KRTAP15-1 Q3LI76 | 3 | EBI-2850497, EBI-11992140 | |
BINARY | Q96DN2 | MEOX2 Q6FHY5 | 3 | EBI-2850497, EBI-16439278 | |
BINARY | Q96DN2 | NUFIP2 Q7Z417 | 3 | EBI-2850497, EBI-1210753 | |
BINARY | Q96DN2 | ZNF20 P17024 | 3 | EBI-2850497, EBI-717634 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 70-98 | EGF-like 1 | ||||
Sequence: LCSFGCGSGICIAPNVCSCQDGEQGATCP | ||||||
Domain | 142-180 | EGF-like 2; calcium-binding | ||||
Sequence: DIDECVTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQ | ||||||
Domain | 181-219 | EGF-like 3; calcium-binding | ||||
Sequence: DTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCV | ||||||
Domain | 220-262 | EGF-like 4; calcium-binding | ||||
Sequence: DVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRVSCE | ||||||
Region | 292-329 | Disordered | ||||
Sequence: GRPALSPGHSPPSGAPGPPAGVRTTRLPSPTPRLPTSS | ||||||
Region | 360-380 | Disordered | ||||
Sequence: LQGEVMGTPSSPRGPESPRLA | ||||||
Domain | 384-441 | VWFC 1 | ||||
Sequence: SPCWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRCEAACSHPIPSRDGGCCPSCT | ||||||
Domain | 442-502 | VWFC 2 | ||||
Sequence: GCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSCISPECPSGPCQTPPQTDCCTCVPVRCY | ||||||
Domain | 503-560 | VWFC 3 | ||||
Sequence: FHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTCQ | ||||||
Domain | 566-626 | VWFC 4 | ||||
Sequence: TGCSLDDNGVEFPIGQIWSPGDPCELCICQADGSVSCKRTDCVDSCPHPIRIPGQCCPDCS | ||||||
Domain | 627-685 | VWFC 5 | ||||
Sequence: AGCTYTGRIFYNNETFPSVLDPCLSCICLLGSVACSPVDCPITCTYPFHPDGECCPVCR | ||||||
Domain | 686-743 | VWFC 6 | ||||
Sequence: DCNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSCEKVPCQRACADPALLPGDCCSSCP | ||||||
Region | 812-889 | Disordered | ||||
Sequence: TLPTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTPPGAPTLPLASPGAPQPPPVTPERSFSASGAQIVSRWPP | ||||||
Compositional bias | 841-872 | Pro residues | ||||
Sequence: SPRLSPGPSTPPGAPTLPLASPGAPQPPPVTP | ||||||
Region | 903-955 | Disordered | ||||
Sequence: MMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPPVGASRGEESTM | ||||||
Compositional bias | 918-937 | Polar residues | ||||
Sequence: PRVLSPTTSRLSTALAATTH |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 2 isoforms produced by Alternative splicing.
Q96DN2-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length955
- Mass (Da)99,915
- Last updated2009-11-24 v2
- ChecksumB745618AD37E712B
Q96DN2-2
- Name2
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Sequence caution
Features
Showing features for sequence conflict, alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 134 | in Ref. 1; BAB71219 | ||||
Sequence: T → A | ||||||
Alternative sequence | VSP_031230 | 219 | in isoform 2 | |||
Sequence: V → M | ||||||
Alternative sequence | VSP_031231 | 220-955 | in isoform 2 | |||
Sequence: Missing | ||||||
Compositional bias | 841-872 | Pro residues | ||||
Sequence: SPRLSPGPSTPPGAPTLPLASPGAPQPPPVTP | ||||||
Compositional bias | 918-937 | Polar residues | ||||
Sequence: PRVLSPTTSRLSTALAATTH |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK056571 EMBL· GenBank· DDBJ | BAB71219.1 EMBL· GenBank· DDBJ | mRNA | ||
BC052564 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
BC077719 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
BC142624 EMBL· GenBank· DDBJ | AAI42625.1 EMBL· GenBank· DDBJ | mRNA | ||
CH471076 EMBL· GenBank· DDBJ | EAW73932.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY205235 EMBL· GenBank· DDBJ | AAO47606.1 EMBL· GenBank· DDBJ | mRNA | Frameshift |