Q96D09 · GASP2_HUMAN

  • Protein
    G-protein coupled receptor-associated sorting protein 2
  • Gene
    GPRASP2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May play a role in regulation of a variety of G-protein coupled receptors.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentnucleus
Molecular Functionamyloid-beta binding
Molecular FunctionG protein-coupled receptor binding
Biological Processhematopoietic stem cell homeostasis

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    G-protein coupled receptor-associated sorting protein 2
  • Short names
    GASP-2

Gene names

    • Name
      GPRASP2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q96D09
  • Secondary accessions
    • D3DXA0
    • Q8NAB4

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Involvement in disease

Deafness, X-linked, 7 (DFNX7)

  • Note
    • The disease is caused by variants affecting the gene represented in this entry
  • Description
    A congenital form of bilateral mixed or conductive hearing loss, which is progressive in some patients. Additional clinical features include ear anomalies and facial dysmorphism with bilateral ptosis.
  • See also
    MIM:301018
Natural variants in DFNX7
Variant IDPosition(s)ChangeDescription
VAR_081645573A>Nin DFNX7; requires 2 nucleotide substitutions

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_049265173in dbSNP:rs6616421
Natural variantVAR_081645573in DFNX7; requires 2 nucleotide substitutions

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 835 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00002390531-838UniProtG-protein coupled receptor-associated sorting protein 2
Modified residue282UniProtPhosphoserine
Modified residue (large scale data)282PRIDEPhosphoserine
Modified residue284UniProtPhosphoserine
Modified residue (large scale data)284PRIDEPhosphoserine
Modified residue (large scale data)328PRIDEPhosphoserine
Modified residue (large scale data)330PRIDEPhosphoserine
Modified residue (large scale data)512PRIDEPhosphoserine
Modified residue (large scale data)550PRIDEPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in the brain.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Interacts with cytoplasmic tails of a variety of G-protein coupled receptors such as muscarinic acetylcholine receptor M1/CHRM1 and calcitonin receptor/CALCR.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q96D09CAVIN3 Q969G53EBI-473189, EBI-3893101
BINARY Q96D09CBX8 Q9HC526EBI-473189, EBI-712912
BINARY Q96D09CCDC146 Q8IYE03EBI-473189, EBI-10749669
BINARY Q96D09CFAP206 Q8IYR06EBI-473189, EBI-749051
BINARY Q96D09EFCAB3 Q8N7B9-23EBI-473189, EBI-11958551
BINARY Q96D09EFHA1 A0A0S2Z6B03EBI-473189, EBI-16439972
BINARY Q96D09FAM124B Q9H5Z6-23EBI-473189, EBI-11986315
BINARY Q96D09FCHSD2 O94868-33EBI-473189, EBI-11958845
BINARY Q96D09FOXD4L1 Q9NU393EBI-473189, EBI-11320806
BINARY Q96D09GADD45GIP1 Q8TAE83EBI-473189, EBI-372506
BINARY Q96D09HLA-A Q5SUL53EBI-473189, EBI-8561769
BINARY Q96D09HTT P428585EBI-473189, EBI-466029
BINARY Q96D09LMO3 Q8TAP4-43EBI-473189, EBI-11742507
BINARY Q96D09MBD3L2 Q8NHZ73EBI-473189, EBI-11989378
BINARY Q96D09PIH1D2 Q8WWB53EBI-473189, EBI-10232538
BINARY Q96D09PLAC9 Q5JTB63EBI-473189, EBI-3923605
BINARY Q96D09PRPF3 O433953EBI-473189, EBI-744322
BINARY Q96D09 Q5W1503EBI-473189, EBI-10248148
BINARY Q96D09RABGEF1 Q9UJ41-43EBI-473189, EBI-14093916
BINARY Q96D09REX1BD Q96EN93EBI-473189, EBI-745810
BINARY Q96D09RHPN1 Q8TCX53EBI-473189, EBI-746325
BINARY Q96D09RNF8 O760643EBI-473189, EBI-373337
BINARY Q96D09RTL10 Q7L3V23EBI-473189, EBI-10697720
BINARY Q96D09SAPCD2 Q86UD03EBI-473189, EBI-2561646
BINARY Q96D09SETDB1 Q15047-23EBI-473189, EBI-9090795
BINARY Q96D09SEZ6L Q9BYH1-53EBI-473189, EBI-12012146
BINARY Q96D09SH2D4A Q9H7883EBI-473189, EBI-747035
BINARY Q96D09SREK1 Q8WXA93EBI-473189, EBI-1044237
BINARY Q96D09TBRG4 Q969Z03EBI-473189, EBI-702328
BINARY Q96D09TCF25 Q9BQ7011EBI-473189, EBI-745182
BINARY Q96D09TTC23 Q5W5X9-33EBI-473189, EBI-9090990
BINARY Q96D09TXN2 Q997574EBI-473189, EBI-2932492
BINARY Q96D09USP20 Q9Y2K63EBI-473189, EBI-2511991
BINARY Q96D09YWHAG P619814EBI-473189, EBI-359832
BINARY Q96D09ZC2HC1C Q53FD0-23EBI-473189, EBI-14104088
BINARY Q96D09ZFYVE26 Q68DK2-53EBI-473189, EBI-8656416
BINARY Q96D09ZNF688 A0A0S2Z5X43EBI-473189, EBI-16429014

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region1-122Disordered
Compositional bias10-35Basic and acidic residues
Region218-292Disordered
Compositional bias223-242Polar residues
Compositional bias244-258Basic and acidic residues
Compositional bias275-292Polar residues
Region349-368Disordered
Region531-552Disordered

Sequence similarities

Belongs to the GPRASP family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    838
  • Mass (Da)
    93,773
  • Last updated
    2001-12-01 v1
  • Checksum
    2D30515916B7EACE
MTGAEIEPSAQAKPEKKAGEEVIAGPERENDVPLVVRPKVRTQATTGARPKTETKSVPAARPKTEAQAMSGARPKTEVQVMGGARPKTEAQGITGARPKTDARAVGGARSKTDAKAIPGARPKDEAQAWAQSEFGTEAVSQAEGVSQTNAVAWPLATAESGSVTKSKGLSMDRELVNVDAETFPGTQGQKGIQPWFGPGEETNMGSWCYSRPRAREEASNESGFWSADETSTASSFWTGEETSVRSWPREESNTRSRHRAKHQTNPRSRPRSKQEAYVDSWSGSEDEASNPFSFWVGENTNNLFRPRVREEANIRSKLRTNREDCFESESEDEFYKQSWVLPGEEANSRFRHRDKEDPNTALKLRAQKDVDSDRVKQEPRFEEEVIIGSWFWAEKEASLEGGASAICESEPGTEEGAIGGSAYWAEEKSSLGAVAREEAKPESEEEAIFGSWFWDRDEACFDLNPCPVYKVSDRFRDAAEELNASSRPQTWDEVTVEFKPGLFHGVGFRSTSPFGIPEEASEMLEAKPKNLELSPEGEEQESLLQPDQPSPEFTFQYDPSYRSVREIREHLRARESAESESWSCSCIQCELKIGSEEFEEFLLLMDKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSSRVRTSFLENMIHMAPPYPNLNMIETFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYMSGFLSLLTTANARTKFHVLKMLLNLSENPAVAKKLFSAKALSIFVGLFNIEETNDNIQIVIKMFQNISNIIKSGKMSLIDDDFSLEPLISAFREFEELAKQLQAQIDNQNDPEVGQQS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias10-35Basic and acidic residues
Compositional bias223-242Polar residues
Compositional bias244-258Basic and acidic residues
Compositional bias275-292Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL035427
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471190
EMBL· GenBank· DDBJ
EAW54727.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471190
EMBL· GenBank· DDBJ
EAW54728.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471190
EMBL· GenBank· DDBJ
EAW54729.1
EMBL· GenBank· DDBJ
Genomic DNA
BC013576
EMBL· GenBank· DDBJ
AAH13576.1
EMBL· GenBank· DDBJ
mRNA
BC036772
EMBL· GenBank· DDBJ
AAH36772.1
EMBL· GenBank· DDBJ
mRNA
AK092981
EMBL· GenBank· DDBJ
-mRNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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