FUNCTION, SUBCELLULAR LOCATION, SUBUNIT, CHARACTERIZATION OF VARIANTS MC1DN19 TRP-352 AND SER-430, MUTAGENESIS OF TYR-327; TYR-349; TYR-359; TYR-410 AND TYR-411
Results show that depletion of FOXRED1 in myoblasts results in decreased levels of fully assembled complexes I and II. FOXRED1 associates with the ND1-containing subcomplexes of ~370 kDa and ~620 kDa and that FOXRED1 activity is required for the formation of a 550-kDa subcomplex of complex I.
Loss of FOXRED1 coupled with protein choline and/or folate-deficient diets results in the depletion of glutathione the dysregulation of nitric oxide metabolism and the peroxynitrite-mediated inactivation of complex I.
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