Q96CM8 · ACSF2_HUMAN
- ProteinMedium-chain acyl-CoA ligase ACSF2, mitochondrial
- GeneACSF2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids615 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA (PubMed:17762044).
Has some preference toward medium-chain substrates (PubMed:17762044).
Plays a role in adipocyte differentiation (PubMed:16380219).
Has some preference toward medium-chain substrates (PubMed:17762044).
Plays a role in adipocyte differentiation (PubMed:16380219).
Catalytic activity
- a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate
- ATP + CoA + octanoate = AMP + diphosphate + octanoyl-CoA
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial matrix | |
Molecular Function | ATP binding | |
Molecular Function | long-chain fatty acid-CoA ligase activity | |
Molecular Function | medium-chain fatty acid-CoA ligase activity | |
Biological Process | acyl-CoA metabolic process | |
Biological Process | fatty acid metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Chemistry
Names & Taxonomy
Protein names
- Recommended nameMedium-chain acyl-CoA ligase ACSF2, mitochondrial
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ96CM8
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_038304 | 75 | in dbSNP:rs17856448 | |||
Sequence: G → V | ||||||
Natural variant | VAR_038305 | 316 | in dbSNP:rs3744523 | |||
Sequence: V → M |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 679 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for transit peptide, chain, modified residue (large scale data), modified residue.
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Transit peptide | 1-41 | UniProt | Mitochondrion | ||||
Sequence: MAVYVGMLRLGRLCAGSSGVLGARAALSRSWQEARLQGVRF | |||||||
Chain | PRO_0000315793 | 42-615 | UniProt | Medium-chain acyl-CoA ligase ACSF2, mitochondrial | |||
Sequence: LSSREVDRMVSTPIGGLSYVQGCTKKHLNSKTVGQCLETTAQRVPEREALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKALVFPKQFKTQQYYNVLKQICPEVENAQPGALKSQRLPDLTTVISVDAPLPGTLLLDEVVAAGSTRQHLDQLQYNQQFLSCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQLRMILPNPLYHCLGSVAGTMMCLMYGATLILASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMKDLVVAYGTTENSPVTFAHFPEDTVEQKAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQMERHLNL | |||||||
Modified residue (large scale data) | 52 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 179 | UniProt | N6-acetyllysine | ||||
Sequence: K | |||||||
Modified residue | 182 | UniProt | N6-acetyllysine; alternate | ||||
Sequence: K | |||||||
Modified residue | 182 | UniProt | N6-succinyllysine; alternate | ||||
Sequence: K | |||||||
Modified residue | 340 | UniProt | N6-acetyllysine | ||||
Sequence: K | |||||||
Modified residue | 398 | UniProt | N6-acetyllysine | ||||
Sequence: K | |||||||
Modified residue | 478 | UniProt | N6-succinyllysine | ||||
Sequence: K | |||||||
Modified residue | 510 | UniProt | N6-acetyllysine | ||||
Sequence: K | |||||||
Modified residue | 544 | UniProt | N6-acetyllysine; alternate | ||||
Sequence: K | |||||||
Modified residue | 544 | UniProt | N6-succinyllysine; alternate | ||||
Sequence: K | |||||||
Modified residue | 570 | UniProt | N6-acetyllysine; alternate | ||||
Sequence: K | |||||||
Modified residue | 570 | UniProt | N6-succinyllysine; alternate | ||||
Sequence: K | |||||||
Modified residue | 599 | UniProt | N6-succinyllysine | ||||
Sequence: K |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Binary interactions
Protein-protein interaction databases
Miscellaneous
Structure
Sequence & Isoforms
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 4 isoforms produced by Alternative splicing.
Q96CM8-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length615
- Mass (Da)68,125
- Last updated2008-01-15 v2
- ChecksumA3356EEA7C14730B
Q96CM8-2
- Name2
- Differences from canonical
- 43-43: S → SARGGMEAGRQRISVPSSFTASAAAH
Q96CM8-3
- Name3
- Differences from canonical
- 146-158: Missing
Q96CM8-4
- Name4
- Differences from canonical
- 1-160: Missing
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Features
Showing features for alternative sequence.
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY358660 EMBL· GenBank· DDBJ | AAQ89023.1 EMBL· GenBank· DDBJ | mRNA | ||
AK024573 EMBL· GenBank· DDBJ | BAB14930.1 EMBL· GenBank· DDBJ | mRNA | ||
AK294205 EMBL· GenBank· DDBJ | BAG57517.1 EMBL· GenBank· DDBJ | mRNA | ||
AK295258 EMBL· GenBank· DDBJ | BAG58247.1 EMBL· GenBank· DDBJ | mRNA | ||
AK300625 EMBL· GenBank· DDBJ | BAG62317.1 EMBL· GenBank· DDBJ | mRNA | ||
AC004707 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC021491 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471109 EMBL· GenBank· DDBJ | EAW94612.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC012053 EMBL· GenBank· DDBJ | AAH12053.1 EMBL· GenBank· DDBJ | mRNA | ||
BC014123 EMBL· GenBank· DDBJ | AAH14123.1 EMBL· GenBank· DDBJ | mRNA |