Q96C92 · ENTR1_HUMAN

  • Protein
    Endosome-associated-trafficking regulator 1
  • Gene
    ENTR1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis (PubMed:23108400, PubMed:25278552, PubMed:27767179).
Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552).
Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 (PubMed:23108400).
Plays a role in the formation of cilia (PubMed:27767179).
Involved in cargo protein localization, such as PKD2, at primary cilia (PubMed:27767179).
Involved in the presentation of the tumor necrosis factor (TNF) receptor TNFRSF1A on the cell surface, and hence in the modulation of the TNF-induced apoptosis (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcentrosome
Cellular Componentciliary basal body
Cellular Componentearly endosome
Cellular Componentendosome
Cellular Componentmidbody
Cellular Componentrecycling endosome
Biological Processcell division
Biological Processcell projection organization
Biological Processendocytic recycling
Biological Processpositive regulation of cilium assembly
Biological Processpositive regulation of protein localization to cilium
Biological Processprotein transport
Biological Processregulation of cytokinesis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Endosome-associated-trafficking regulator 1
  • Alternative names
    • Antigen NY-CO-3
    • Serologically defined colon cancer antigen 3

Gene names

    • Name
      ENTR1
    • Synonyms
      SDCCAG3

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q96C92
  • Secondary accessions
    • A6NCP1
    • O60525
    • Q5SXN1
    • Q5SXN2
    • Q5SXN3

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Early endosome
Endosome
Recycling endosome
Midbody
Note: Colocalizes in a WASHC2-dependent manner with the retromer CSC complex at endosomes (PubMed:25278552).
During cytokinesis colocalized with PTPN13 at the midbody (PubMed:23108400).
Colocalizes with IFT88 and gamma-tubulin at the basal body of primary cilia (PubMed:27767179).
Colocalizes with IFT88 and pericentrin at the centrosome (PubMed:27767179).

Keywords

Disease & Variants

Features

Showing features for natural variant, mutagenesis.

TypeIDPosition(s)Description
Natural variantVAR_039687157in dbSNP:rs7047681
Natural variantVAR_039688176in dbSNP:rs17851182
Mutagenesis190Disrupts interaction with PTPN13.
Mutagenesis194Disrupts interaction with PTPN13.
Natural variantVAR_039689304in dbSNP:rs3812577
Natural variantVAR_039690379in dbSNP:rs1131992
Natural variantVAR_039691428in dbSNP:rs17855450

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 649 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00003242851-435UniProtEndosome-associated-trafficking regulator 1
Modified residue18UniProtPhosphoserine
Modified residue (large scale data)132PRIDEPhosphotyrosine
Modified residue147UniProtPhosphoserine
Modified residue (large scale data)240PRIDEPhosphoserine
Modified residue243UniProtPhosphoserine
Modified residue (large scale data)243PRIDEPhosphoserine
Modified residue247UniProtPhosphoserine
Modified residue (large scale data)247PRIDEPhosphoserine
Modified residue (large scale data)249PRIDEPhosphoserine
Modified residue (large scale data)258PRIDEPhosphoserine
Modified residue (large scale data)270PRIDEPhosphoserine
Modified residue (large scale data)301PRIDEPhosphothreonine
Modified residue (large scale data)435PRIDEPhosphoserine

Post-translational modification

Phosphorylated.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in the colon (at protein level).

Gene expression databases

Organism-specific databases

Interaction

Subunit

Found in a complex with ENTR1, PTPN13 and GIT1 (PubMed:23108400).
Interacts with PTPN13 (via the FERM domain) (PubMed:23108400).
Interacts (via N-terminus) with GIT1 (via N- and C-terminus); this interaction is direct (PubMed:23108400).
Interacts with NOD2 (PubMed:27812135).
Interacts (via N-terminus) with IFT88 (PubMed:27767179).
Interacts with VPS35 (PubMed:25278552).

Binary interactions

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias, coiled coil.

TypeIDPosition(s)Description
Region136-185Disordered
Compositional bias143-157Polar residues
Region173-198Required for interaction with PTPN13
Region225-251Disordered
Compositional bias230-244Polar residues
Coiled coil261-371

Domain

Tne N-terminal domain is necessary and sufficient for basal body localization and ciliogenesis.

Sequence similarities

Belongs to the ENTR1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (4)
  • Sequence status
    Complete

This entry describes 4 isoforms produced by Alternative splicing.

Q96C92-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    435
  • Mass (Da)
    47,961
  • Last updated
    2008-03-18 v3
  • Checksum
    03EBD9512232B5E3
MSGYQRRPGATPLSRARSLAIPDAPAFYERRSCLPQLNCERPHGRDLDSPFFGIRPAFMCYVPSPVLASVGDTDFGYGKGKCSKQSPSGAHGTHFGDDRFEDLEEANPFSFREFLKTKNLGLSKEDPASRIYAKEASRHSLGLDHNSPPSQTGGYGLEYQQPFFEDPTGAGDLLDEEEDEDTGWSGAYLPSAIEQTHPERVPAGTSPCSTYLSFFSTPSELAGPESLPSWALSDTDSRVSPASPAGSPSADFAVHGESLGDRHLRTLQISYDALKDENSKLRRKLNEVQSFSEAQTEMVRTLERKLEAKMIKEESDYHDLESVVQQVEQNLELMTKRAVKAENHVVKLKQEISLLQAQVSNFQRENEALRCGQGASLTVVKQNADVALQNLRVVMNSAQASIKQLVSGAETLNLVAEILKSIDRISEVKDEEEDS

Q96C92-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q96C92-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q96C92-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
B5MDD7B5MDD7_HUMANENTR1108
A0A0A0MRP9A0A0A0MRP9_HUMANENTR1223
H7C331H7C331_HUMANENTR1167

Sequence caution

The sequence BAA91607.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Features

Showing features for alternative sequence, sequence conflict, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0321761-58in isoform 3
Sequence conflict7in Ref. 4; AAH14515
Alternative sequenceVSP_04047724-96in isoform 4
Alternative sequenceVSP_03217775-97in isoform 2
Compositional bias143-157Polar residues
Compositional bias230-244Polar residues
Sequence conflict343in Ref. 1; AAQ56721

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY349357
EMBL· GenBank· DDBJ
AAQ56721.1
EMBL· GenBank· DDBJ
mRNA
CR597452
EMBL· GenBank· DDBJ
-mRNA No translation available.
AL592301
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471090
EMBL· GenBank· DDBJ
EAW88230.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471090
EMBL· GenBank· DDBJ
EAW88231.1
EMBL· GenBank· DDBJ
Genomic DNA
BC014515
EMBL· GenBank· DDBJ
AAH14515.2
EMBL· GenBank· DDBJ
mRNA
AK001296
EMBL· GenBank· DDBJ
BAA91607.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AF039688
EMBL· GenBank· DDBJ
AAC18037.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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