Q96C92 · ENTR1_HUMAN
- ProteinEndosome-associated-trafficking regulator 1
- GeneENTR1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids435 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis (PubMed:23108400, PubMed:25278552, PubMed:27767179).
Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552).
Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 (PubMed:23108400).
Plays a role in the formation of cilia (PubMed:27767179).
Involved in cargo protein localization, such as PKD2, at primary cilia (PubMed:27767179).
Involved in the presentation of the tumor necrosis factor (TNF) receptor TNFRSF1A on the cell surface, and hence in the modulation of the TNF-induced apoptosis (By similarity).
Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552).
Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 (PubMed:23108400).
Plays a role in the formation of cilia (PubMed:27767179).
Involved in cargo protein localization, such as PKD2, at primary cilia (PubMed:27767179).
Involved in the presentation of the tumor necrosis factor (TNF) receptor TNFRSF1A on the cell surface, and hence in the modulation of the TNF-induced apoptosis (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | centrosome | |
Cellular Component | ciliary basal body | |
Cellular Component | early endosome | |
Cellular Component | endosome | |
Cellular Component | midbody | |
Cellular Component | recycling endosome | |
Biological Process | cell division | |
Biological Process | cell projection organization | |
Biological Process | endocytic recycling | |
Biological Process | positive regulation of cilium assembly | |
Biological Process | positive regulation of protein localization to cilium | |
Biological Process | protein transport | |
Biological Process | regulation of cytokinesis |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameEndosome-associated-trafficking regulator 1
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ96C92
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Colocalizes in a WASHC2-dependent manner with the retromer CSC complex at endosomes (PubMed:25278552).
During cytokinesis colocalized with PTPN13 at the midbody (PubMed:23108400).
Colocalizes with IFT88 and gamma-tubulin at the basal body of primary cilia (PubMed:27767179).
Colocalizes with IFT88 and pericentrin at the centrosome (PubMed:27767179).
During cytokinesis colocalized with PTPN13 at the midbody (PubMed:23108400).
Colocalizes with IFT88 and gamma-tubulin at the basal body of primary cilia (PubMed:27767179).
Colocalizes with IFT88 and pericentrin at the centrosome (PubMed:27767179).
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant, mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_039687 | 157 | in dbSNP:rs7047681 | |||
Sequence: L → V | ||||||
Natural variant | VAR_039688 | 176 | in dbSNP:rs17851182 | |||
Sequence: E → G | ||||||
Mutagenesis | 190 | Disrupts interaction with PTPN13. | ||||
Sequence: P → A | ||||||
Mutagenesis | 194 | Disrupts interaction with PTPN13. | ||||
Sequence: E → A | ||||||
Natural variant | VAR_039689 | 304 | in dbSNP:rs3812577 | |||
Sequence: R → Q | ||||||
Natural variant | VAR_039690 | 379 | in dbSNP:rs1131992 | |||
Sequence: V → M | ||||||
Natural variant | VAR_039691 | 428 | in dbSNP:rs17855450 | |||
Sequence: V → I |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 649 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000324285 | 1-435 | UniProt | Endosome-associated-trafficking regulator 1 | |||
Sequence: MSGYQRRPGATPLSRARSLAIPDAPAFYERRSCLPQLNCERPHGRDLDSPFFGIRPAFMCYVPSPVLASVGDTDFGYGKGKCSKQSPSGAHGTHFGDDRFEDLEEANPFSFREFLKTKNLGLSKEDPASRIYAKEASRHSLGLDHNSPPSQTGGYGLEYQQPFFEDPTGAGDLLDEEEDEDTGWSGAYLPSAIEQTHPERVPAGTSPCSTYLSFFSTPSELAGPESLPSWALSDTDSRVSPASPAGSPSADFAVHGESLGDRHLRTLQISYDALKDENSKLRRKLNEVQSFSEAQTEMVRTLERKLEAKMIKEESDYHDLESVVQQVEQNLELMTKRAVKAENHVVKLKQEISLLQAQVSNFQRENEALRCGQGASLTVVKQNADVALQNLRVVMNSAQASIKQLVSGAETLNLVAEILKSIDRISEVKDEEEDS | |||||||
Modified residue | 18 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 132 | PRIDE | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue | 147 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 240 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 243 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 243 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 247 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 247 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 249 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 258 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 270 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 301 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 435 | PRIDE | Phosphoserine | ||||
Sequence: S |
Post-translational modification
Phosphorylated.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in the colon (at protein level).
Gene expression databases
Organism-specific databases
Interaction
Subunit
Found in a complex with ENTR1, PTPN13 and GIT1 (PubMed:23108400).
Interacts with PTPN13 (via the FERM domain) (PubMed:23108400).
Interacts (via N-terminus) with GIT1 (via N- and C-terminus); this interaction is direct (PubMed:23108400).
Interacts with NOD2 (PubMed:27812135).
Interacts (via N-terminus) with IFT88 (PubMed:27767179).
Interacts with VPS35 (PubMed:25278552).
Interacts with PTPN13 (via the FERM domain) (PubMed:23108400).
Interacts (via N-terminus) with GIT1 (via N- and C-terminus); this interaction is direct (PubMed:23108400).
Interacts with NOD2 (PubMed:27812135).
Interacts (via N-terminus) with IFT88 (PubMed:27767179).
Interacts with VPS35 (PubMed:25278552).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q96C92-2 | AP1M1 Q9BXS5 | 3 | EBI-10178036, EBI-541426 | |
BINARY | Q96C92-2 | AXIN1 A0A0S2Z4M1 | 3 | EBI-10178036, EBI-16429430 | |
BINARY | Q96C92-2 | DDX6 P26196 | 3 | EBI-10178036, EBI-351257 | |
BINARY | Q96C92-2 | SDCBP O00560 | 3 | EBI-10178036, EBI-727004 | |
BINARY | Q96C92-2 | TFPT P0C1Z6-2 | 3 | EBI-10178036, EBI-10178002 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 136-185 | Disordered | ||||
Sequence: ASRHSLGLDHNSPPSQTGGYGLEYQQPFFEDPTGAGDLLDEEEDEDTGWS | ||||||
Compositional bias | 143-157 | Polar residues | ||||
Sequence: LDHNSPPSQTGGYGL | ||||||
Region | 173-198 | Required for interaction with PTPN13 | ||||
Sequence: LLDEEEDEDTGWSGAYLPSAIEQTHP | ||||||
Region | 225-251 | Disordered | ||||
Sequence: ESLPSWALSDTDSRVSPASPAGSPSAD | ||||||
Compositional bias | 230-244 | Polar residues | ||||
Sequence: WALSDTDSRVSPASP | ||||||
Coiled coil | 261-371 | |||||
Sequence: DRHLRTLQISYDALKDENSKLRRKLNEVQSFSEAQTEMVRTLERKLEAKMIKEESDYHDLESVVQQVEQNLELMTKRAVKAENHVVKLKQEISLLQAQVSNFQRENEALRC |
Domain
Tne N-terminal domain is necessary and sufficient for basal body localization and ciliogenesis.
Sequence similarities
Belongs to the ENTR1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 4 isoforms produced by Alternative splicing.
Q96C92-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length435
- Mass (Da)47,961
- Last updated2008-03-18 v3
- Checksum03EBD9512232B5E3
Q96C92-2
- Name2
- Differences from canonical
- 75-97: Missing
Q96C92-3
- Name3
- Differences from canonical
- 1-58: Missing
Q96C92-4
- Name4
- Differences from canonical
- 24-96: Missing
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
B5MDD7 | B5MDD7_HUMAN | ENTR1 | 108 | ||
A0A0A0MRP9 | A0A0A0MRP9_HUMAN | ENTR1 | 223 | ||
H7C331 | H7C331_HUMAN | ENTR1 | 167 |
Sequence caution
Features
Showing features for alternative sequence, sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_032176 | 1-58 | in isoform 3 | |||
Sequence: Missing | ||||||
Sequence conflict | 7 | in Ref. 4; AAH14515 | ||||
Sequence: R → H | ||||||
Alternative sequence | VSP_040477 | 24-96 | in isoform 4 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_032177 | 75-97 | in isoform 2 | |||
Sequence: Missing | ||||||
Compositional bias | 143-157 | Polar residues | ||||
Sequence: LDHNSPPSQTGGYGL | ||||||
Compositional bias | 230-244 | Polar residues | ||||
Sequence: WALSDTDSRVSPASP | ||||||
Sequence conflict | 343 | in Ref. 1; AAQ56721 | ||||
Sequence: N → T |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY349357 EMBL· GenBank· DDBJ | AAQ56721.1 EMBL· GenBank· DDBJ | mRNA | ||
CR597452 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
AL592301 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471090 EMBL· GenBank· DDBJ | EAW88230.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471090 EMBL· GenBank· DDBJ | EAW88231.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC014515 EMBL· GenBank· DDBJ | AAH14515.2 EMBL· GenBank· DDBJ | mRNA | ||
AK001296 EMBL· GenBank· DDBJ | BAA91607.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AF039688 EMBL· GenBank· DDBJ | AAC18037.1 EMBL· GenBank· DDBJ | mRNA |