our study uncovers a protein complex which consists of SWS1 SWSAP1 SPIDR and PDS5B involved in DNA repair and provides insight into Shu complex function and composition
first time we have identified the -100/+41 to -70/+41 bp core promoter regions of Swiprosin-1 gene and showed ADR1 and Sp1 are important transcription factors that directly bind to and transactivate the Swiprosin-1 promoter region.
MOES ANXA5 and EFHD2 were confirmed by selected reaction monitoring to be correlated to monocytic differentiation and could be biomarkers for disease stratification in AML
EFHD2 was identified as expressed in highly metastatic tumor cells. EFHD2 increased the formation of protrusive invadopodia structures and cell migration and invasion abilities and promoted the epithelial-to-mesenchymal transition (EMT) character of lung adenocarcinoma cells. We demonstrated that the mechanism of EFHD2 in enhancing EMT occurs partly through inhibition of caveolin-1 (CAV1) for cancer progression.
Phosphorylation at Ser183 of EFhd2 causes changes in the local conformational dynamics and the surface charge distribution of the actin-binding site resulting in a re-coordination of the actin-binding sites in the dimer structure., Phosphorylation
Data demonstrate that EFhd2 shows unique structural and biological features as an EF-hand containing F-actin bundling protein. For F-actin bundling activity structural stabilization of the EF-hand domains was found to occur in the presence of Ca2+. The core region of EFhd2 maintains its structure in the absence of Ca2+ ; however changes in local conformational flexibility reduce F-actin bundling activity of EFhd2.
Swiprosin-1 is involved in regulating the accessibility of F-actin to cofilin through the clustering of F-actin and the activity of Swiprosin-1 is highly dependent on its phosphorylation status at Ser183
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