Q96BU1 · S1PBP_HUMAN
- ProteinS100P-binding protein
- GeneS100PBP
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids408 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nuclear speck | |
Cellular Component | nucleus | |
Molecular Function | calcium-dependent protein binding |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameS100P-binding protein
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ96BU1
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Colocalizes with S100P in the nucleus.
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 514 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data), modified residue.
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000317051 | 1-408 | UniProt | S100P-binding protein | |||
Sequence: MMCSRVPSEQSSGTSLLPKDGAPFSWDSLDEDGLDDSLLELSEGEEDDGDVNYTEEEIDALLKEDDPSYEQSSGEDDGGHVEKGERGSQILLDTPREKNSSYSLGPVAETPDLFKLPQLSTSSGHGPAHTKPLNRRSVLEKNLIKVTVAPFNPTVCDALLDKDETDSSKDTEKLSSLGEEMREDGLSPNESKLCTESEGISPNNSAWNGPQLSSSNNNFQQTVSDKNMPDSENPTSVFSRISDHSETPNMELSCRNGGSHKSSCEMRSLVVSTSSNKQDVLNKDSGKMKGHERRLGKVIPVLQTKTRTNVPTFSQSNLEQQKQLYLRSVIAHIEDPEDTNQGISGELCALMDQVHHMQHSKWQHPSDLTTRNYARRQKHLQRYSLTQWVDRNMRSHHRFQRLPDFSYS | |||||||
Modified residue (large scale data) | 94 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 101 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 187 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 187 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 201 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in brain, spleen, and lung. Not detected in pancreas or liver. In pancreas, expressed predominantly in islet cells and to a lesser extent in acinar cells, but not expressed in ductal cells. Up-regulated in various pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasias. Detected in pancreatic ductal adenocarcinoma cells (at protein level). Not detected in non-neoplastic ductal epithelium (at protein level).
Gene expression databases
Organism-specific databases
Interaction
Subunit
Interacts with S100P.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q96BU1 | NUDT21 O43809 | 3 | EBI-18959794, EBI-355720 | |
BINARY | Q96BU1 | PCED1B Q96HM7 | 2 | EBI-18959794, EBI-1222622 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-18 | Polar residues | ||||
Sequence: MMCSRVPSEQSSGTSLLP | ||||||
Region | 1-111 | Disordered | ||||
Sequence: MMCSRVPSEQSSGTSLLPKDGAPFSWDSLDEDGLDDSLLELSEGEEDDGDVNYTEEEIDALLKEDDPSYEQSSGEDDGGHVEKGERGSQILLDTPREKNSSYSLGPVAETP | ||||||
Compositional bias | 29-63 | Acidic residues | ||||
Sequence: LDEDGLDDSLLELSEGEEDDGDVNYTEEEIDALLK | ||||||
Compositional bias | 64-92 | Basic and acidic residues | ||||
Sequence: EDDPSYEQSSGEDDGGHVEKGERGSQILL | ||||||
Compositional bias | 162-189 | Basic and acidic residues | ||||
Sequence: KDETDSSKDTEKLSSLGEEMREDGLSPN | ||||||
Region | 162-234 | Disordered | ||||
Sequence: KDETDSSKDTEKLSSLGEEMREDGLSPNESKLCTESEGISPNNSAWNGPQLSSSNNNFQQTVSDKNMPDSENP | ||||||
Compositional bias | 190-234 | Polar residues | ||||
Sequence: ESKLCTESEGISPNNSAWNGPQLSSSNNNFQQTVSDKNMPDSENP | ||||||
Region | 271-291 | Disordered | ||||
Sequence: VSTSSNKQDVLNKDSGKMKGH |
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q96BU1-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length408
- Mass (Da)45,582
- Last updated2001-12-01 v1
- ChecksumC366D258BEF3AAF5
Q96BU1-2
- Name2
- Differences from canonical
- 343-408: Missing
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Sequence caution
Features
Showing features for compositional bias, sequence conflict, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-18 | Polar residues | ||||
Sequence: MMCSRVPSEQSSGTSLLP | ||||||
Compositional bias | 29-63 | Acidic residues | ||||
Sequence: LDEDGLDDSLLELSEGEEDDGDVNYTEEEIDALLK | ||||||
Compositional bias | 64-92 | Basic and acidic residues | ||||
Sequence: EDDPSYEQSSGEDDGGHVEKGERGSQILL | ||||||
Compositional bias | 162-189 | Basic and acidic residues | ||||
Sequence: KDETDSSKDTEKLSSLGEEMREDGLSPN | ||||||
Compositional bias | 190-234 | Polar residues | ||||
Sequence: ESKLCTESEGISPNNSAWNGPQLSSSNNNFQQTVSDKNMPDSENP | ||||||
Sequence conflict | 329 | in Ref. 1; BAB14335 | ||||
Sequence: V → L | ||||||
Alternative sequence | VSP_052661 | 343-408 | in isoform 2 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK022965 EMBL· GenBank· DDBJ | BAB14335.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AK090711 EMBL· GenBank· DDBJ | BAG52216.1 EMBL· GenBank· DDBJ | mRNA | ||
BX647667 EMBL· GenBank· DDBJ | CAI46038.1 EMBL· GenBank· DDBJ | mRNA | ||
CH471059 EMBL· GenBank· DDBJ | EAX07503.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471059 EMBL· GenBank· DDBJ | EAX07504.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471059 EMBL· GenBank· DDBJ | EAX07505.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC015175 EMBL· GenBank· DDBJ | AAH15175.1 EMBL· GenBank· DDBJ | mRNA |