Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch.
- Cited forNUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH PSEN1; PSEN2 AND NCSTN
- TissueGlioblastoma
- CategoriesFunction, Sequences, Interaction
- SourceUniProtKB reviewed (Swiss-Prot)