Leucine point mutations viz. L215H L217R and L225M were reported for paclitaxel resistance in various cancers. In the current study molecular mechanism of these resistance causing mutations in TUBB1 was explored using molecular docking molecular dynamics simulation binding energy estimation free energy decomposition principle component analysis and free energy landscape methods.
mechanism of binding and stabilization of microtubules in mammalian cells can be effectively modeled in yeast and also having the advantage of lacking any beta-tubulin isotypes that can complicate interpretation of experiments in mammalian cells.
results provide insight into the functional repertoire of the tubulin gene family specifically implicating TUBB5 in embryonic neurogenesis and microcephaly
Allele frequencies between a group of 191 ITP patients & controls showed no direct aetiological role for SNP (R307H) but it was associated with immunomodulatory treatment failure.
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
Data show that knockdown of S100P led to downregulation of thioredoxin 1 and beta-tubulin and upregulation of RhoGDIA all potential therapeutic targets in cancer.
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