Q96AY4 · TTC28_HUMAN

  • Protein
    Tetratricopeptide repeat protein 28
  • Gene
    TTC28
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcentrosome
Cellular Componentcytoplasm
Cellular Componentmidbody
Cellular Componentspindle pole
Molecular Functionkinase binding
Biological Processcell division
Biological Processregulation of mitotic cell cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tetratricopeptide repeat protein 28
  • Short names
    TPR repeat protein 28
  • Alternative names
    • TPR repeat-containing big gene cloned at Keio

Gene names

    • Name
      TTC28
    • Synonyms
      KIAA1043, TPRBK

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q96AY4
  • Secondary accessions
    • K7ZRV2
    • O95928
    • O95929
    • Q5W189
    • Q9NTE4

Proteomes

Organism-specific databases

Subcellular Location

Midbody
Note: At interphase, localizes to centrosomes. At prometaphase and metaphase, associated with spindle microtubules and spindle poles. At anaphase, accumulates in the spindle midzone. At telophase, condensed on central spindles. During cytokinesis, condensed on the midbody where it colocalizes with AURKB (By similarity).

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 2,191 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue, chain, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue1UniProtN-acetylmethionine
ChainPRO_00001064271-2481UniProtTetratricopeptide repeat protein 28
Modified residue (large scale data)4PRIDEPhosphoserine
Modified residue (large scale data)16PRIDEPhosphothreonine
Modified residue28UniProtPhosphoserine
Modified residue (large scale data)28PRIDEPhosphoserine
Modified residue (large scale data)32PRIDEPhosphoserine
Modified residue (large scale data)47PRIDEPhosphoserine
Modified residue (large scale data)1372PRIDEPhosphoserine
Modified residue1590UniProtPhosphoserine
Modified residue (large scale data)2079PRIDEPhosphoserine
Modified residue (large scale data)2102PRIDEPhosphoserine
Modified residue2104UniProtPhosphoserine
Modified residue (large scale data)2104PRIDEPhosphoserine
Modified residue (large scale data)2105PRIDEPhosphothreonine
Modified residue (large scale data)2108PRIDEPhosphoserine
Modified residue (large scale data)2117PRIDEPhosphoserine
Modified residue (large scale data)2120PRIDEPhosphoserine
Modified residue2224UniProtPhosphoserine
Modified residue (large scale data)2224PRIDEPhosphoserine
Modified residue (large scale data)2227PRIDEPhosphoserine
Modified residue2251UniProtPhosphoserine
Modified residue (large scale data)2251PRIDEPhosphoserine
Modified residue (large scale data)2271PRIDEPhosphoserine
Modified residue (large scale data)2293PRIDEPhosphoserine
Modified residue (large scale data)2295PRIDEPhosphotyrosine
Modified residue (large scale data)2302PRIDEPhosphoserine
Modified residue (large scale data)2307PRIDEPhosphoserine
Modified residue (large scale data)2335PRIDEPhosphoserine
Modified residue (large scale data)2367PRIDEPhosphothreonine
Modified residue2393UniProtPhosphoserine
Modified residue2398UniProtPhosphoserine
Modified residue (large scale data)2398PRIDEPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Widely expressed in fetal tissues. In adult tissues, expressed in testis and ovary and, at much lower levels, in kidney and pancreas.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Interacts with AURKB.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, repeat, compositional bias.

TypeIDPosition(s)Description
Region1-48Disordered
Repeat58-91TPR 1
Repeat93-125TPR 2
Repeat126-159TPR 3
Repeat196-229TPR 4
Repeat234-267TPR 5
Repeat274-307TPR 6
Repeat314-347TPR 7
Repeat354-387TPR 8
Repeat394-427TPR 9
Repeat434-467TPR 10
Repeat474-507TPR 11
Repeat514-547TPR 12
Repeat554-587TPR 13
Repeat594-627TPR 14
Repeat634-667TPR 15
Repeat674-707TPR 16
Repeat714-747TPR 17
Repeat754-787TPR 18
Repeat794-827TPR 19
Repeat834-867TPR 20
Repeat877-910TPR 21
Repeat917-950TPR 22
Repeat957-990TPR 23
Repeat997-1030TPR 24
Repeat1037-1070TPR 25
Repeat1077-1110TPR 26
Repeat1117-1150TPR 27
Repeat1169-1202TPR 28
Region2004-2055Disordered
Compositional bias2030-2046Polar residues
Region2075-2161Disordered
Compositional bias2091-2148Polar residues
Region2176-2339Disordered
Compositional bias2183-2228Polar residues
Compositional bias2240-2286Polar residues
Compositional bias2295-2334Polar residues
Region2420-2467Disordered

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,481
  • Mass (Da)
    270,884
  • Last updated
    2008-12-16 v4
  • Checksum
    D646D744EBFCFE35
MEQSPPPAPEPTQGPTPARSRRRREPESPPASAPIPLFGADTIGQRSPDGPVLSKAEFVEKVRQSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLEPTYQQLQKMKLDKSPFVVVSVVGQELLTAGHHGASVVVLEAALKIGTCSLKLRGSVFSALSSAYWSLGNTEKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKDINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSLGRTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWASGNLEEAQHQLYRASALFETIRHEAQLSTDYKLSLFDLQTSSYQALQRVLVSLGHHDEALAVAERGRTRAFADLLVERQTGQQDSDPYSPVTIDQILEMVNGQRGLVLYYSLAAGYLYSWLLAPGAGIVKFHEHYLGENTVENSSDFQASSSVTLPTATGSALEQHIASVREALGVESHYSRACASSETESEAGDIMDQQFEEMNNKLNSVTDPTGFLRMVRRNNLFNRSCQSMTSLFSNTVSPTQDGTSSLPRRQSSFAKPPLRALYDLLIAPMEGGLMHSSGPVGRHRQLILVLEGELYLIPFALLKGSSSNEYLYERFGLLAVPSIRSLSVQSKSHLRKNPPTYSSSTSMAAVIGNPKLPSAVMDRWLWGPMPSAEEEAYMVSELLGCQPLVGSVATKERVMSALTQAECVHFATHISWKLSALVLTPSMDGNPASSKSSFGHPYTIPESLRVQDDASDGESISDCPPLQELLLTAADVLDLQLPVKLVVLGSSQESNSKVTADGVIALTRAFLAAGAQCVLVSLWPVPVAASKMFIHAFYSSLLNGLKASAALGEAMKVVQSSKAFSHPSNWAGFMLIGSDVKLNSPSSLIGQALTEILQHPERARDALRVLLHLVEKSLQRIQNGQRNAMYTSQQSVENKVGGIPGWQALLTAVGFRLDPPTSGLPAAVFFPTSDPGDRLQQCSSTLQSLLGLPNPALQALCKLITASETGEQLISRAVKNMVGMLHQVLVQLQAGEKEQDLASAPIQVSISVQLWRLPGCHEFLAALGFDLCEVGQEEVILKTGKQANRRTVHFALQSLLSLFDSTELPKRLSLDSSSSLESLASAQSVSNALPLGYQQPPFSPTGADSIASDAISVYSLSSIASSMSFVSKPEGGSEGGGPGGRQDHDRSKNAYLQRSTLPRSQLPPQTRPAGNKDEEEYEGFSIISNEPLATYQENRNTCFSPDHKQPQPGTAGGMRVSVSSKGSISTPNSPVKMTLIPSPNSPFQKVGKLASSDTGESDQSSTETDSTVKSQEESNPKLDPQELAQKILEETQSHLIAVERLQRSGGQVSKSNNPEDGVQAPSSTAVFRASETSAFSRPVLSHQKSQPSPVTVKPKPPARSSSLPKVSSGYSSPTTSEMSIKDSPSQHSGRPSPGCDSQTSQLDQPLFKLKYPSSPYSAHISKSPRNMSPSSGHQSPAGSAPSPALSYSSAGSARSSPADAPDIDKLKMAAIDEKVQAVHNLKMFWQSTPQHSTGPMKIFRGAPGTMTSKRDVLSLLNLSPRHNKKEEGVDKLELKELSLQQHDGAPPKAPPNGHWRTETTSLGSLPLPAGPPATAPARPLRLPSGNGYKFLSPGRFFPSSKC

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
B0QYP4B0QYP4_HUMANTTC28108
B0QYP5B0QYP5_HUMANTTC28301
A0A087WW06A0A087WW06_HUMANTTC282354

Sequence caution

The sequence AAH16465.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence CAB62963.1 differs from that shown. Reason: Erroneous gene model prediction
The sequence CAB62964.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias2030-2046Polar residues
Compositional bias2091-2148Polar residues
Compositional bias2183-2228Polar residues
Compositional bias2240-2286Polar residues
Compositional bias2295-2334Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB665284
EMBL· GenBank· DDBJ
BAM66822.1
EMBL· GenBank· DDBJ
mRNA
AL008724
EMBL· GenBank· DDBJ
CAB62963.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
AL008724
EMBL· GenBank· DDBJ
CAB62964.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
AL121825
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL023281
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL050313
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL035453
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL035397
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL033538
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
ES313581
EMBL· GenBank· DDBJ
-mRNA No translation available.
BU584912
EMBL· GenBank· DDBJ
-mRNA No translation available.
AB028966
EMBL· GenBank· DDBJ
BAA82995.3
EMBL· GenBank· DDBJ
mRNA
BC016465
EMBL· GenBank· DDBJ
AAH16465.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AL080174
EMBL· GenBank· DDBJ
CAB45760.2
EMBL· GenBank· DDBJ
mRNA
AL137328
EMBL· GenBank· DDBJ
CAB70697.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp